Article
Immunology
Jiang Zhang, Melanie Wencker, Quentin Marliac, Aurore Berton, Uzma Hasan, Raphael Schneider, Daphne Laubreton, Dylan E. Cherrier, Anne-Laure Mathieu, Amaury Rey, Wenzheng Jiang, Julie Caramel, Laurent Genestier, Antoine Marcais, Jacqueline Marvel, Yad Ghavi-Helm, Thierry Walzer
Summary: Zeb1 is a key regulator of T cell development, promoting the survival and proliferation of DN2 and DP cells by influencing cell cycle and TCR signaling. Zeb1 mutation leads to the virtual absence of unconventional T cell subsets while maintaining a normal number of conventional T cells, suggesting a disruption in thymocyte selection process.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Pirooz Zareie, Christopher Szeto, Carine Farenc, Sachith D. Gunasinghe, Elizabeth M. Kolawole, Angela Nguyen, Chantelle Blyth, Xavier Y. X. Sng, Jasmine Li, Claerwen M. Jones, Alex J. Fulcher, Jesica R. Jacobs, Qianru Wei, Lukasz Wojciech, Jan Petersen, Nicholas R. J. Gascoigne, Brian D. Evavold, Katharina Gaus, Stephanie Gras, Jamie Rossjohn, Nicole L. La Gruta
Summary: The study found that the T cell receptor recognizes peptide-major histocompatibility complexes with a highly conserved docking polarity, which affects T cell activation and recruitment in vivo. The canonical docking of TCR-pMHCI is essential for optimal T cell signaling.
Article
Immunology
Wei Luo, Julia Z. Z. Adamska, Chunfeng Li, Rohit Verma, Qing Liu, Thomas Hagan, Florian Wimmers, Shakti Gupta, Yupeng Feng, Wenxia Jiang, Jiehao Zhou, Erika Valore, Yanli Wang, Meera Trisal, Shankar Subramaniam, Timothy F. Osborne, Bali Pulendran
Summary: Our previous study showed that the sterol regulatory binding protein (SREBP) pathway is associated with humoral immune response. We generated mice with specific deletion of SCAP, an essential regulator of SREBP signaling, in B cells or CD11c(+) antigen-presenting cells (APCs). Deletion of SCAP in CD11c(+) APCs had no impact on immune responses, whereas SREBP signaling in B cells was crucial for antibody responses and the development of immune cells. These studies reveal the regulatory role of sterol metabolism in humoral immunity.
Review
Immunology
Arianne C. Richard
Summary: The advent of technologies that can characterize individual cells has revealed extensive diversity between cells of the same subset, including CD8(+) T cells. This review focuses on heterogeneity in CD8(+) T cell responses, particularly the impact of TCR stimulation strength and the mechanisms underlying variation between cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Saran Pankaew, Delphine Potier, Clemence Grosjean, Mathis Nozais, Julie Quessada, Marie Loosveld, Elisabeth Remy, Dominique Payet-Bornet
Summary: This study investigates the functional interaction between TCRαβ signaling and PTEN in the development of T-cell acute lymphoblastic leukemia (T-ALL). The results suggest that PTEN loss affects the ITPR/calcium flux pathway, highlighting a potential role of PTEN in the regulation of ITPR proteins in thymocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuanyuan Liu, Shuai Chen, Simon Liu, Kevin L. Wallace, Marietta Zille, Jiewen Zhang, Jian Wang, Chao Jiang
Summary: Stroke is a severe and life-threatening disease that requires more research on new treatment strategies. Infiltrated T lymphocytes play a crucial role in post-stroke inflammation and have conflicting roles as therapeutic targets. Understanding the mechanisms of the adaptive immune response associated with T lymphocytes is essential for developing effective treatments.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Shohei Harabuchi, Omar Khan, Hamid Bassiri, Taku Yoshida, Yohei Okada, Masaomi Takizawa, Osamu Ikeda, Akihiro Katada, Taku Kambayashi
Summary: This study investigates the role of TCR signaling pathways in chronic viral infection, revealing the distinct effects of DAG and ERK on CD8+ T cell activation and survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Rashmi Tippalagama, Leila Y. Chihab, Kendall Kearns, Sloan Lewis, Sudhasini Panda, Lisa Willemsen, Julie G. Burel, Cecilia Lindestam S. Arlehamn
Summary: TCR sequencing allows tracking of specific antigen-specific T cells and their clonal expansion, and has been widely used to study the role of these cells in different diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Ashwathi Puravankara Menon, Beatriz Moreno, Daniel Meraviglia-Crivelli, Francesca Nonatelli, Helena Villanueva, Martin Barainka, Angelina Zheleva, Hisse M. van Santen, Fernando Pastor
Summary: CD3 complex is the first signal sensed by TCR of lymphocytes for activation, making it an attractive receptor to determine immune response fate. This article discusses the assembly of CD3-TCR complex and the approaches to harness CD3 activity for immunotherapy.
Article
Immunology
Heloise Flament, Matthieu Rouland, Lucie Beaudoin, Amine Toubal, Leo Bertrand, Samuel Lebourgeois, Camille Rousseau, Pauline Soulard, Zouriatou Gouda, Lucie Cagninacci, Antoine C. Monteiro, Margarita Hurtado-Nedelec, Sandrine Luce, Karine Bailly, Muriel Andrieu, Benjamin Saintpierre, Franck Letourneur, Youenn Jouan, Mustapha Si-Tahar, Thomas Baranek, Christophe Paget, Christian Boitard, Anais Vallet-Pichard, Jean-Francois Gautier, Nadine Ajzenberg, Benjamin Terrier, Frederic Pene, Jade Ghosn, Xavier Lescure, Yazdan Yazdanpanah, Benoit Visseaux, Diane Descamps, Jean-Francois Timsit, Renato C. Monteiro, Agnes Lehuen
Summary: Severe cases of COVID-19 are characterized by immune system dysfunction, particularly a significant reduction and high activation of mucosal-associated invariant T (MAIT) cells. These cells play a crucial role in disease severity and mortality, correlating with the activation of inflammatory cytokines and cytotoxic phenotype.
Review
Immunology
Matthew Clark, Charles J. Kroger, Qi Ke, Roland M. Tisch
Summary: TCR signaling plays a crucial role in the development of T cells and the formation of self-reactive T cells, particularly in type 1 diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Niels C. Lory, Mikolaj Nawrocki, Martina Corazza, Joanna Schmid, Valea Schumacher, Tanja Bedke, Stephan Menzel, Friedrich Koch-Nolte, Andreas H. Guse, Samuel Huber, Hans-Willi Mittruecker
Summary: This study investigates the function of TRPM2 in T-cell activation and differentiation using TRPM2-deficient mice. The results suggest that TRPM2 does not play a major role in T-cell activation and differentiation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Ming-Ming Shao, Feng-Shuang Yi, Zhong-Yin Huang, Peng Peng, Feng-Yao Wu, Huan-Zhong Shi, Kan Zhai
Summary: Characterization of T cell receptor repertoires in tuberculous patients revealed differences in TCR sequences, hydrophobicity, and usage patterns between CD4(+) and CD8(+) T cells. A new subset of polyfunctional CD4(+) T cells with protective immunity against Mtb was identified.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Wei Li, Junjie Kou, Zhenxi Zhang, Haoyue Li, Li Li, Wenjing Du
Summary: Research reveals that MYC gene plays an important role in driving T cell lymphomagenesis, and malic enzyme 2 (ME2), an enzyme associated with glutamine metabolism, is essential in this process. By establishing a CD4-Cre; Myc flox/+ transgenic mouse model, it is found that knockout of Me2 significantly suppresses T cell lymphomagenesis. Mechanistically, MYC up-regulates ME2 to maintain redox homeostasis, while ME2 stimulates mTORC1 activity through adjusting glutamine metabolism, promoting MYC translation. Overall, these findings highlight the crucial role of ME2 in MYC-driven T cell lymphomagenesis and suggest the MYC-ME2 circuit as a potential target for TCL therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Che-Mai Chang, Kang-Yung Peng, Chieh-Kai Chan, Yu-Feng Lin, Hung-Wei Liao, Jan-Gowth Chang, Mai-Szu Wu, Vin-Cent Wu, Wei-Chiao Chang
Summary: This study demonstrates that patients with aldosterone-producing adenoma (APA) have reduced T-cell immune repertoire diversity and exhibit differences compared to patients with hypertension. The study also reveals a stronger correlation between T-cell receptor (TCR) clonotype generation probabilities and frequencies in the APA group. Clinical features are positively associated with the strength of correlation between TCR clonotype generation and abundance in the APA group.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Seungwon Ryu, Joon Seok Park, Hye Young Kim, Ji Hyung Kim
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Joon Seok Park, Ji Hyung Kim
MOLECULAR IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Marc-Werner Dobenecker, Jonas Marcello, Annette Becker, Eugene Rudensky, Natarajan Bhanu, Thomas Carrol, Benjamin A. Garcia, Rabinder Prinjha, Vyacheslav Yurchenko, Alexander Tarakhovsky
Article
Biochemistry & Molecular Biology
Ho-Jae Lee, Joon Seok Park, Hyun Jung Yoo, Hae Min Lee, Byung Cheon Lee, Ji Hyung Kim
Article
Multidisciplinary Sciences
Ian J. Groves, Sarah E. Jackson, Emma L. Poole, Aharon Nachshon, Batsheva Rozman, Michal Schwartz, Rab K. Prinjha, David F. Tough, John H. Sinclair, Mark R. Wills
Summary: HCMV reactivation from latency poses a significant health risk for transplant recipients. Epigenetic inhibitors, particularly histone deacetylase inhibitors and bromodomain inhibitors, have been found effective in inducing virus immediate early gene expression, providing a potential strategy for reducing HCMV-related morbidity and mortality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Chun-Shan Liu, Inmaculada Rioja, Ali Bakr, Marlon R. Veldwijk, Elena Sperk, Carsten Herskind, Dieter Weichenhan, Rab K. Prinjha, Christoph Plass, Peter Schmezer, Odilia Popanda
Summary: This study investigated the effects and toxicity of different inhibitors targeting BET proteins on radiation-induced fibroblast activation. The results showed that BD2-selective targeting inhibitors efficiently suppressed the expression of DGKA and profibrotic markers without showing cytotoxicity.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Nathaniel G. Jones, Vincent Geoghegan, Gareth Moore, Juliana B. T. Carnielli, Katherine Newling, Felix Calderon, Raquel Gabarro, Julio Martin, Rab K. Prinjha, Inmaculada Rioja, Anthony J. Wilkinson, Jeremy C. Mottram
Summary: Leishmania require the bromodomain-enriched CRKT complex for interpreting histone acetylation marks and maintaining normal gene expression and cellular viability.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Cong-Hui Yao, Joon Seok Park, Kiran Kurmi, Song-Hua Hu, Giulia Notarangelo, Joseph Crowley, Heidi Jacobson, Sheng Hui, Arlene H. Sharpe, Marcia C. Haigis
Summary: The glycerol-3-phosphate shuttle is uncoupled in kidney cancer cells, with the cytosolic reaction being much faster than the mitochondrial reaction. Knocking down mitochondrial GPD has no effect on mitochondrial respiration, but leads to upregulation of cytosolic GPD and increased glycerol-3-phosphate supply, promoting cancer cell proliferation. Inhibition of lipid synthesis can abolish the proliferative advantage of GPD2 knockdown tumor.
Article
Multidisciplinary Sciences
Joon Seok Park, Francesca S. Gazzaniga, Meng Wu, Amalia K. Luthens, Jacob Gillis, Wen Zheng, Martin W. LaFleur, Sarah B. Johnson, Golnaz Morad, Elizabeth M. Park, Yifan Zhou, Stephanie S. Watowich, Jennifer A. Wargo, Gordon J. Freeman, Dennis L. Kasper, Arlene H. Sharpe
Summary: The gut microbiota plays a vital role in regulating anti-tumor immunity during immune checkpoint inhibitor therapy. Certain bacteria have been found to promote an anti-tumor response to immune checkpoint inhibitors in mice, and transplanting fecal samples from responders can improve the efficacy of anti-PD-1 therapy in melanoma patients. However, the effectiveness of fecal transplants varies, and the mechanisms by which gut bacteria promote anti-tumor immunity are still unclear.
Correction
Multidisciplinary Sciences
Joon Seok Park, Francesca S. Gazzaniga, Meng Wu, Amalia K. Luthens, Jacob Gillis, Wen Zheng, Martin W. LaFleur, Sarah B. Johnson, Golnaz Morad, Elizabeth M. Park, Yifan Zhou, Stephanie S. Watowich, Jennifer A. Wargo, Gordon J. Freeman, Dennis L. Kasper, Arlene H. Sharpe
Review
Immunology
Alexander Tarakhovsky, Rab K. Prinjha
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)