EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production

Metabolic Regulation of the Immune Humoral Response

(2017) Mark Boothby et al.   IMMUNITY

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

(2017) Anthony T. Phan et al.   IMMUNITY

EZH2 Regulates the Developmental Timing of Effectors of the Pre–Antigen Receptor Checkpoints

(2017) Jennifer A. Jacobsen et al.   JOURNAL OF IMMUNOLOGY

Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

(2017) Elisa Oricchio et al.   Science Translational Medicine

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

(2017) Arantxa Pérez-García et al.   Nature Communications

Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control

(2017) C Pawlyn et al.   Blood Cancer Journal

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

(2016) Wendy Béguelin et al.   CANCER CELL

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

(2016) Wafik S. El-Deiry   CANCER RESEARCH

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

(2016) Wing Y. Lam et al.   IMMUNITY

mTOR has distinct functions in generating versus sustaining humoral immunity

(2016) Derek D. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation

(2016) Benjamin G Barwick et al.   NATURE IMMUNOLOGY

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

(2016) Martina Minnich et al.   NATURE IMMUNOLOGY

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions

(2016) Mohammad Alzrigat et al.   Oncotarget

ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells

(2016) Christopher D. Scharer et al.   Scientific Reports

Whole-genome fingerprint of the DNA methylome during human B cell differentiation

(2015) Marta Kulis et al.   NATURE GENETICS

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

(2015) Wei Shi et al.   NATURE IMMUNOLOGY

Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment

(2015) Christopher D. Scharer et al.   NUCLEIC ACIDS RESEARCH

Manipulation of B-cell responses with histone deacetylase inhibitors

(2015) Michaela Waibel et al.   Nature Communications

Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response

(2015) Hong Zan et al.   Frontiers in Immunology

The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells

(2014) J. Zhang et al.   BLOOD

Tn5 transposase and tagmentation procedures for massively scaled sequencing projects

(2014) Simone Picelli et al.   GENOME RESEARCH

B Cell Differentiation Is Associated with Reprogramming the CCCTC Binding Factor-Dependent Chromatin Architecture of the Murine MHC Class II Locus

(2014) P. Majumder et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ

(2014) Kim L. Good-Jacobson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Germinal Center, B-Cell Memory, and Plasma Cell Formation by Histone Modifiers

(2014) Kim L. Good-Jacobson   Frontiers in Immunology

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation

(2013) A. Y. Lai et al.   GENOME RESEARCH

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis

(2013) Marieta Caganova et al.   JOURNAL OF CLINICAL INVESTIGATION

The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes

(2013) Alberto Frangini et al.   MOLECULAR CELL

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Epigenetics of the antibody response

(2013) Guideng Li et al.   TRENDS IN IMMUNOLOGY

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis

(2012) Roger Revilla-i-Domingo et al.   EMBO JOURNAL

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

ZBTB32 Is an Early Repressor of the CIITA and MHC Class II Gene Expression during B Cell Differentiation to Plasma Cells

(2012) H. S. Yoon et al.   JOURNAL OF IMMUNOLOGY

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

(2012) M. T. McCabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation

(2011) R. Shaknovich et al.   BLOOD

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

(2011) Malay Mandal et al.   NATURE IMMUNOLOGY

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

The genetic network controlling plasma cell differentiation

(2011) Stephen L. Nutt et al.   SEMINARS IN IMMUNOLOGY

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

(2010) I. Velichutina et al.   BLOOD

Follicular B Cell Trafficking within the Spleen Actively Restricts Humoral Immune Responses

(2010) Kristen L. Hoek et al.   IMMUNITY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Genome-Wide Promoter Analysis of the SOX4 Transcriptional Network in Prostate Cancer Cells

(2009) C. D. Scharer et al.   CANCER RESEARCH

Involvement of Histone Demethylase LSD1 in Blimp-1-Mediated Gene Repression during Plasma Cell Differentiation

(2009) S.-T. Su et al.   MOLECULAR AND CELLULAR BIOLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

Plasma cell development: From B-cell subsets to long-term survival niches

(2008) Kirsten A. Fairfax et al.   SEMINARS IN IMMUNOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY