Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

ASC in Renal Collecting Duct Epithelial Cells Contributes to Inflammation and Injury after Unilateral Ureteral Obstruction

(2014) Takanori Komada et al.   AMERICAN JOURNAL OF PATHOLOGY

Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice

(2013) P. Luo et al.   DIABETOLOGIA

The signaling pathway for aldosterone-induced mitochondrial production of superoxide anion in the myocardium

(2013) M.B. Nolly et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status

(2013) Yuko Nishi et al.   KIDNEY INTERNATIONAL

Rapid aldosterone actions on epithelial sodium channel trafficking and cell proliferation

(2013) Sinéad Quinn et al.   STEROIDS

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

(2012) Yugang Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia

(2012) Chun Zhang et al.   HYPERTENSION

The effect of antihypertensive drugs on chronic kidney disease: a comprehensive review

(2012) Anastasia G Ptinopoulou et al.   HYPERTENSION RESEARCH

Natriuretic Peptide Receptor Guanylyl Cyclase-A Protects Podocytes from Aldosterone-Induced Glomerular Injury

(2012) Y. Ogawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II–induced cardiac, renal, and vascular injury

(2012) James M. Luther et al.   KIDNEY INTERNATIONAL

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

(2012) Amy McCurley et al.   NATURE MEDICINE

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

(2011) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury

(2011) H Tokuyama et al.   INTERNATIONAL JOURNAL OF OBESITY

Non-genomic actions of aldosterone: From receptors and signals to membrane targets

(2011) Ruth Dooley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Managing kidney disease with blood-pressure control

(2011) Elke Wühl et al.   Nature Reviews Nephrology

Deterioration of glomerular endothelial surface layer induced by oxidative stress is implicated in altered permeability of macromolecules in Zucker fatty rats

(2010) A. Kuwabara et al.   DIABETOLOGIA

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Critical Role of Apoptosis Signal-Regulating Kinase 1 in Aldosterone/Salt-Induced Cardiac Inflammation and Fibrosis

(2009) Taishi Nakamura et al.   HYPERTENSION

Antifibrotic Effects of Aldosterone Receptor Blocker (Spironolactone) in Patients with Chronic Kidney Disease

(2009) Ibrahim Guney et al.   RENAL FAILURE

The Aggravating Mechanisms of Aldosterone on Kidney Fibrosis

(2008) G. Remuzzi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE