Synthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration

Multiscale reconstruction of a synthetic biomimetic micro-niche for enhancing and monitoring the differentiation of stem cells

(2018) Rui Li et al.   BIOMATERIALS

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α/NF-κB–Wnt5a negative-feedback loop

(2018) Z. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand

(2018) Julia Luther et al.   Science Translational Medicine

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling

(2017) Shunsuke Uehara et al.   Science Signaling

Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation

(2017) Sien Lin et al.   Stem Cell Research & Therapy

Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue

(2017) Liangliang Xu et al.   Stem Cell Research & Therapy

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling

(2017) Shunsuke Uehara et al.   Science Signaling

Curvature and Rho activation differentially control the alignment of cells and stress fibers

(2017) Nathan D. Bade et al.   Science Advances

Hydrogels functionalized with N-cadherin mimetic peptide enhance osteogenesis of hMSCs by emulating the osteogenic niche

(2016) Meiling Zhu et al.   BIOMATERIALS

Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation

(2016) Hai-Di Fu et al.   JOURNAL OF MOLECULAR HISTOLOGY

Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells

(2016) Lubna M. Mehdawi et al.   Molecular Oncology

Mimicking biological functionality with polymers for biomedical applications

(2016) Jordan J. Green et al.   NATURE

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization

(2016) Chengzhu Zhao et al.   Science Signaling

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

(2016) Lomeli R. Carpio et al.   Science Signaling

Hyperelastic “bone”: A highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial

(2016) Adam E. Jakus et al.   Science Translational Medicine

Wnt5a Supports Osteogenic Lineage Decisions in Embryonic Stem Cells

(2016) Kevin C. Keller et al.   STEM CELLS AND DEVELOPMENT

Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization

(2016) Chengzhu Zhao et al.   Science Signaling

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

(2016) Lomeli R. Carpio et al.   Science Signaling

Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells

(2015) Yunfeng Rui et al.   Scientific Reports

The osteoblastic niche in the context of multiple myeloma

(2014) Denise Toscani et al.   Annals of the New York Academy of Sciences

The WNT-5a derived peptide, Foxy-5, possesses dual properties that impair progression of ERα negative breast cancer

(2014) Caroline E. Ford et al.   CELL CYCLE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis

(2014) Masanori Okamoto et al.   Scientific Reports

Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis – A review

(2013) Roman A. Surmenev et al.   Acta Biomaterialia

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis

(2013) L. Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

(2013) Jianjian Shi et al.   Cell Death & Disease

Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis

(2012) Eiji Nemoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-α in human mesenchymal stem cells

(2012) A. Briolay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling

(2012) J. Bao et al.   Science Signaling

Human Mesenchymal Stem Cell-Derived Matrices for Enhanced Osteoregeneration

(2012) S. Zeitouni et al.   Science Translational Medicine

Wnt5a: its signalling, functions and implication in diseases

(2011) A. Kikuchi et al.   Acta Physiologica

WNT5A induces osteogenic differentiation of human adipose stem cells via rho-associated kinase Rock

(2010) Ana Santos et al.   CYTOTHERAPY