Article
Materials Science, Multidisciplinary
Chunhua Li, Mengfan Wu, Jianyong Liu, Ruoyun Wang, Chaoyi Wei, Rui Wang, Yunlong Zhou, Haihong Jiang, Jingye Pan, Chuanfei Guo
Summary: In this study, a noninvasive wireless measurement system for urinary bladder pressure (UBP) was proposed, using a biomimetic structured piezoresistive sensor and low-power Bluetooth. The system exhibited high sensitivity, robustness, and real-time data transmission, providing an efficient strategy for clinicians or patients to diagnose abdominal impairment in real-time.
APPLIED MATERIALS TODAY
(2022)
Review
Chemistry, Analytical
Xiaohua Jia, Guodong Shen, Jia Jia, Yan Zhang, Dan Zhang, Wanjun Li, Jianjun Zhang, Xinglu Huang, Jie Tian
Summary: This article introduces the importance of cancer stem cells and the method of lineage tracing, as well as the application of molecular imaging in the dynamic detection of cancer stem cells. The article analyzes the current situation and looks forward to the future development of cancer stem cell detection.
Article
Multidisciplinary Sciences
Michael Spencer Chapman, Anna Maria Ranzoni, Brynelle Myers, Nicholas Williams, Tim H. H. Coorens, Emily Mitchell, Timothy Butler, Kevin J. Dawson, Yvette Hooks, Luiza Moore, Jyoti Nangalia, Philip S. Robinson, Kenichi Yoshida, Elizabeth Hook, Peter J. Campbell, Ana Cvejic
Summary: By reconstructing a phylogenetic tree of blood development in healthy human fetuses, it was found that individual haematopoietic progenitors acquire multiple somatic mutations by 18 weeks after conception. The data also support a hypoblast origin of the extra-embryonic mesoderm and primitive blood in humans.
Article
Multidisciplinary Sciences
Andy Chan, Sophia Ma, Bret J. Pearson, Danny Chan
Summary: The extracellular matrix plays a crucial role in the maintenance, regeneration, and differentiation of stem cells within their niche. By studying the collagen gene family in the freshwater planarian Schmidtea mediterranea, researchers have identified a key gene, col4-1, which influences the proliferation of neoblasts. Furthermore, evidence suggests that an interaction between type IV collagen, the discoidin domain receptor, and neuregulin-7 regulate the balance of symmetric and asymmetric division of neoblasts through the NRG-7/EGFR pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Biomedical
Kshitiz Raj Shrestha, Do Hoon Lee, Woojae Chung, Seung-Wuk Lee, Byung Yang Lee, So Young Yoo
Summary: The engineered nanofibrous phage provides therapeutic cues for de novo soft tissue niche engineering, promoting the proper functioning of implanted stem cells and enhancing blood vessel regeneration.
Review
Biology
Chunyi Li, Peter Fennessy
Summary: Periosteum is a complex composite structure that serves as a protective membrane for bones, mechano-sensor, reservoir of biochemical molecules, niche for osteogenic cells, and nourishing cord for bone tissue. It also contains stem cell attributes and plays a crucial role in ectopic organ formation and organ regeneration in mammals. Recent studies have shown successful partial regeneration of amputated rat legs through manipulation of periosteum, showing potential for further advancements in human health.
Article
Engineering, Electrical & Electronic
Vicente A. de Oliveira, Andres Pablo L. Barbero, Leandro A. Sphaier, Alexandre B. dos Santos, Fernando C. Peixoto, Vinicius N. H. Silva
Summary: A refractometer based on EFBGs sensor was developed for real-time monitoring of beer fermentation, which showed high sensitivity to density variations and could accurately respond under different sugar and ethanol concentrations with a well-fitted empirical model. The developed sensor was tested in a typical scenario, establishing a material balance framework to relate the fit calibration model to actual density and alcohol content in real-time. The sensor can be fitted in fermentation vessels for online monitoring, offering a technological improvement to traditional offline measurements in terms of biosafety and process control.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Review
Materials Science, Biomaterials
Kuan Un Wong, Anyu Zhang, Behnam Akhavan, Marcela M. Bilek, Giselle C. Yeo
Summary: Conventional MSC culture methods have been shown to induce senescence and decrease functionality over time, with high costs. To retain the functional value of expanded MSCs, it is important to recreate the components of the native stem cell microenvironment in ex vivo culture systems. Current research focuses on incorporating biochemical and biophysical cues in MSC culture platforms to grow clinically relevant cell numbers while preserving cell potency.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Yan Wang, Yue Gong, Shenming Huang, Xuechao Xing, Ziyu Lv, Junjie Wang, Jia-Qin Yang, Guohua Zhang, Ye Zhou, Su-Ting Han
Summary: The study developed an artificial LGMD visual neuron using light-mediated threshold switching memristor to mimic the escape response of LGMD neuron. Additionally, robot navigation with obstacle avoidance capability and biomimetic compound eyes with wide field-of-view detection capability were demonstrated.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Sungkyu Lee, Myeong Soo Kim, Kapil D. Patel, Hyojun Choi, Ramar Thangam, Jinho Yoon, Thomas Myeongseok Koo, Hee Joon Jung, Sunhong Min, Gunhyu Bae, Yuri Kim, Seong-Beom Han, Nayeon Kang, Minjin Kim, Na Li, Hong En Fu, Yoo Sang Jeon, Jae-Jun Song, Dong-Hwee Kim, Steve Park, Jeong-Woo Choi, Ramasamy Paulmurugan, Yun Chan Kang, Heon Lee, Qiang Wei, Vinayak P. Dravid, Ki-Bum Lee, Young Keun Kim, Heemin Kang
Summary: The density of ligand nanoassembly on Fe3O4 nanoparticle can be dynamically changed to control stem cell differentiation. Magnetic control of rising and falling ligand movements influences adhesion and differentiation processes through intermolecular interactions.
Article
Biochemistry & Molecular Biology
Xinan H. Yang, Andrew Goldstein, Yuxi Sun, Zhezhen Wang, Megan Wei, Ivan P. Moskowitz, John M. Cunningham
Summary: Single-cell transcriptome analysis is crucial for understanding cellular state transitions. BioTIP, utilizing tipping-point theory and feature selection, overcomes challenges in identifying critical transition signals and inferring lineage-determining transcription factors.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yuki Yokoi, Takahiro Adachi, Rina Sugimoto, Mani Kikuchi, Tokiyoshi Ayabe, Kiminori Nakamura
Summary: The study showed that Lgr5+ ISCs undergo cell death earlier than Paneth cells in response to IFN-gamma, and most Paneth cells have overlapping cell death timing with Lgr5+ ISCs, indicating that Paneth cell depletion is directly induced by IFN-gamma. The researchers established a novel simultaneous stem cell niche tracking method and clarified the involvement of both Paneth cells and Lgr5+ ISCs in stem cell niche damage induced by IFN-gamma, contributing further to understanding the mechanism for maintaining intestinal homeostasis by the stem cell niche.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Agronomy
Yue Zhao, Hao Tian, Qiaoling Han, Jiahua Gu, Yandong Zhao
Summary: This study developed a new living wood freeze-thaw detection sensor for real-time, in situ, and micro-destructive monitoring of liquid water and ice content in plant stems. The sensor effectively detected changes in water-related physiological parameters during plant freeze-thaw processes, providing valuable insights for evaluating the effects of winter freeze-thaw on plant metabolism and vitality.
AGRICULTURAL AND FOREST METEOROLOGY
(2021)
Article
Cell Biology
Xueman Zhou, Jin Liu, Yingcheng Zheng, Zhenzhen Zhang, Yange Wu, Wenke Yang, Jiaqi Liu, Yanmei Huang, Yating Yi, Zhihe Zhao, Hengyi Xiao, Xianming Mo, Jun Wang
Summary: Bone stromal cells are essential for bone homeostasis and regeneration. Non-stem bone niche cells support bone homeostasis and regeneration through paracrine mechanisms. Specifically, SM22α lineage stromal cells expand after bone injury, regulating the process of bone regeneration.
Article
Engineering, Electrical & Electronic
Haiming Hui, Shaoling Hu, Wei Chen
Summary: This paper explores how to efficiently, timely, and reliably monitor Brownian motions. By considering the joint effects of quantization error and data sample freshness, an optimal joint sampling and quantization scheme is proposed to balance quantization distortion and age-of-information (AoI). To address the issue of infinite distortion caused by error accumulation, a multi-layer error correction method is introduced for infinite-time monitoring. Furthermore, an error correction mechanism based on periodic feedback is presented to overcome the accumulation of transmission errors in unreliable channels.
IEEE TRANSACTIONS ON COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yingrui Deng, Rui Li, Haixing Wang, Boguang Yang, Peng Shi, Yuan Zhang, Qiang Yang, Gang Li, Liming Bian
Summary: This study utilized a Jagged-1 mimetic peptide ligand to modify hyaluronic acid hydrogels, enhancing osteogenesis and activating the Notch signaling pathway in human mesenchymal stem cells. The functionalization also promoted angiogenesis and in situ regeneration, providing important insights for the design of bioactive biomaterials in biomedical applications.
Article
Engineering, Biomedical
Yingrui Deng, Xiaoting Zhang, Rui Li, Zhuo Li, Boguang Yang, Peng Shi, Honglu Zhang, Chunming Wang, Chunyi Wen, Gang Li, Liming Bian
Summary: This study investigates the efficacy of biofunctionalizing a hyaluronic acid hydrogel with a synthetic Wnt5a mimetic ligand (Foxy5 peptide) to promote the chondrogenesis of human mesenchymal stem cells (hMSCs). The conjugation of Foxy5 peptide in the hydrogels activates non-canonical Wnt signaling, leading to enhanced expression of chondrogenic markers and metabolic activities of encapsulated hMSCs. Furthermore, Foxy5 peptide inhibits hypertrophy of chondrogenically induced hMSCs through multiple signaling pathways. These findings provide valuable insights for the rational design of bio-inductive scaffolds in regenerative medicine.
Article
Multidisciplinary Sciences
Weiyi Qian, Tarik Hadi, Michele Silvestro, Xiao Ma, Cristobal F. Rivera, Apratim Bajpai, Rui Li, Zijing Zhang, Hengdong Qu, Rayan Sleiman Tellaoui, Annanina Corsica, Ariadne L. Zias, Karan Garg, Thomas Maldonado, Bhama Ramkhelawon, Weiqiang Chen
Summary: This study reveals defective mechano-phenotype signatures of vascular smooth muscle cells (VSMC) in abdominal aortic aneurysms (AAA), and identifies Piezo1 as a novel culprit of mechanically fatigued aorta in AAA.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jiwon Oh, Xingyu Xia, Wai Ki Ricky Wong, Siu Hong Dexter Wong, Weihao Yuan, Haixing Wang, Chun Him Nathanael Lai, Ye Tian, Yi-Ping Ho, Honglu Zhang, Yuan Zhang, Gang Li, Yuan Lin, Liming Bian
Summary: The study demonstrates that the large aspect ratio of gold nanorods can enhance T cell activation and promote key cytokine secretion by facilitating anisotropic presentation of stimulatory ligands. The manipulation of extracellular ligand nano-geometry is crucial in optimizing T cell behaviors and improving therapeutic outcomes, as observed in the differentiation of CD8(+) T cells towards the effector phenotype.
Article
Microbiology
Xi Chen, Miao Liu, Pengfei Zhang, Miao Xu, Weihao Yuan, Liming Bian, Yannan Liu, Jiang Xia, Sharon S. Y. Leung
Summary: This study demonstrated that phage-encoded depolymerases can enhance host immune response against bacterial infections, and act as antibiotic adjuvants to improve antibacterial efficacy. Depolymerases also have the ability to inhibit biofilm formation, enhance antibiofilm activity, and improve survival rates in infected hosts.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Di Wang, Wei Zhang, Chunxi Zhang, Liwei Wang, Heng Chen, Jianbin Xu
Summary: Exosomal non-coding RNAs play a crucial role in tumor metastasis by influencing the interaction between tumor cells and the tumor microenvironment through various mechanisms, contributing to the formation of metastatic niches. Therefore, exosomal non-coding RNAs have the potential to serve as diagnostic, prognostic markers, and therapeutic targets for tumors.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Multidisciplinary Sciences
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth, Sergiu P. Pasca
Summary: This study demonstrates the potential of transplanting self-organizing neural organoids derived from human stem cells into the somatosensory cortex of rats to develop mature cell types and integrate into sensory and motivation-related circuits. The transplanted cortical neurons exhibit more complex properties than their in vitro counterparts and can drive reward-seeking behavior when optogenetically activated. This approach has the potential to detect circuit-level phenotypes in patient-derived cells that cannot be uncovered using other methods.
Article
Chemistry, Multidisciplinary
Tianfu Zhang, Xiaoyu Chen, Congmin Yuan, Xiaobin Pang, Ping Shangguan, Yisheng Liu, Lulu Han, Jianwei Sun, Jacky W. Y. Lam, Yang Liu, Jiefei Wang, Bingyang Shi, Ben Zhong Tang
Summary: The researchers designed a near-infrared aggregation-induced emission probe, DNTPH, using a balanced hydrophobicity-hydrophilicity strategy, which selectively binds to A beta fibrils. DNTPH showed excellent blood-brain barrier permeability and long-term tracking ability, making it suitable for high-performance Alzheimer's disease diagnosis. Furthermore, DNTPH exhibited a strong inhibitory effect on A beta fibrosis and promoted fibril disassembly, thereby reducing A beta-induced neurotoxicity. DNTPH treatment significantly reduced A beta plaques and improved learning deficits in AD mice.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biophysics
Miao Cui, Xiaoyu Chen, Xu Luo, Zhihang Zhou, Zhiji Chen, Zhengdong Zhou, Xiaoyu Zhou, Heng Zou, Tao Xu, Shubin Wang, Mengsu Yang
Summary: The study introduces a single-chain based nano lock (SCNL) polymer for capturing a broad spectrum of cancer cells and CTCs overexpressing sialic acid (SA) with high sensitivity and selectivity. High sensitivity is achieved through the polymeric single chain structure and multi-valent functional moieties, while selective targeting is accomplished by the dynamic and dually stimulative nano lock structures.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Heng Chen, Xiao Duan, Jianbin Xu, Biao Wang, Sihan Xiang, Xin Wang
Summary: A water-soluble safe antioxidant, ferulic acid-chitosan complex, was easily prepared in water with mild-temperature heating. The complex exhibits improved water solubility and higher antioxidative property compared to its precursors. This approach enables the development of chitosan-based functional biomaterials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Di Wang, Liwei Wang, Liming Zheng, Jiaxin Chen, Wei Zhang, Wei Zhou, Xiaobo Yang, Lifeng Jiang, Xiaoqiang Jin, Xiaohua Yu, Xin Liu, Heng Chen, Jianbin Xu
Summary: Invasion and metastasis are the leading causes of death in CRC patients. 5-Fluorouracil, a widely used chemotherapy drug for CRC, is inefficient in inhibiting tumor metastasis. MicroRNA-10b, a key regulator of chemotherapeutic resistance to 5-FU, induces early tumor metastases. A nanovehicle called GCD, which targets EGFR, is used to deliver chemotherapeutic and nucleotide drugs to distinct targets in CRC, effectively inhibiting the metastasis of EGFR-overexpressed CRC. The therapeutic effect of this combination is evaluated in tumor xenograft models derived from patients with CRC. Overall, this study provides insights into simultaneous inhibition of tumor growth and metastasis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Xiaoyu Chen, Chunhua Zhao, Dingxin Liu, Kunpeng Lin, Jingnan Lu, Shuang Zhao, Jiang Yang, Huanxin Lin
Summary: This study reports a core-shell-structured Pd1.7Bi@CeO2-ICG (PBCI) nanoplatform for synergistic chemodynamic therapy (CDT), photodynamic therapy (PDT), and photothermal therapy. The PBCI nanoplatform can generate cytotoxic hydroxyl radicals for CDT and relieve tumor hypoxia for enhanced PDT. Additionally, it exhibits good photothermal effect and can be used as a contrast agent for near-infrared fluorescence imaging, enabling effective tumor elimination.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Liwei Wang, Di Wang, Zhaoming Ye, Jianbin Xu
Summary: Extracellular vesicles (EVs) are secreted transport vesicles that play a role in intercellular and inter-organismal communication. EVs can be engineered to deliver bioactivators in therapy, and this review article discusses various aspects of EV engineering, applications in different diseases, and the challenges and possible strategies in EV-based therapies.
Article
Construction & Building Technology
L. S. Platt, Xiaoyu Chen, Tara Sabo-Attwood, Nicole Iovine, Scott Brown, Brad Pollitt
Summary: This research aimed to use a computational approach to assist infection prevention strategies in healthcare environment planning, by analyzing outside design basis factors and their impact on pathogen spread. Supervised Machine Learning methodologies were used to determine relationships between Socioecological System (SES) factors and observed incidence rates of specific Hospital Acquired Infections (HAI). The outcomes of this research suggest the benefit of using SES computational modeling for decision-making in health system Architectural Programming and predesign.
ARCHITECTURAL ENGINEERING AND DESIGN MANAGEMENT
(2023)
Article
Economics
Jing Wang, Feng Wan, Chunjiao Dong, Chaoying Yin, Xiaoyu Chen
Summary: This study, using Beijing as an example, characterized built environment factors by integrating multi-source big data. Three direct ridership models based on the geographically and temporally weighted regression (GTWR) model were proposed to reveal the spatiotemporal effects of these factors on rail transit ridership patterns. The results showed that population density, employment density, entertainment places, bus stations, and parking lots all play important roles in influencing ridership patterns.
JOURNAL OF TRANSPORT GEOGRAPHY
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
