Mimicking biological functionality with polymers for biomedical applications

Condensation on slippery asymmetric bumps

(2016) Kyoo-Chul Park et al.   NATURE

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

(2016) Arturo J Vegas et al.   NATURE BIOTECHNOLOGY

Underwater contact adhesion and microarchitecture in polyelectrolyte complexes actuated by solvent exchange

(2016) Qiang Zhao et al.   NATURE MATERIALS

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

(2016) K. Sadtler et al.   SCIENCE

The design of reversible hydrogels to capture extracellular matrix dynamics

(2016) Adrianne M. Rosales et al.   Nature Reviews Materials

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy

(2015) Karlo Perica et al.   ACS Nano

Self-(Un)rolling Biopolymer Microstructures: Rings, Tubules, and Helical Tubules from the Same Material

(2015) Chunhong Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Towards programming immune tolerance through geometric manipulation of phosphatidylserine

(2015) Reid A. Roberts et al.   BIOMATERIALS

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor

(2015) P. C. Dave P. Dingal et al.   NATURE MATERIALS

A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels

(2015) Cole A. DeForest et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

(2015) Omid Veiseh et al.   NATURE MATERIALS

Tissue matrix arrays for high-throughput screening and systems analysis of cell function

(2015) Vince Z Beachley et al.   NATURE METHODS

Cryopreserved human amniotic membrane and a bioinspired underwater adhesive to seal and promote healing of iatrogenic fetal membrane defect sites

(2015) R. Papanna et al.   PLACENTA

Adaptive synergy between catechol and lysine promotes wet adhesion by surface salt displacement

(2015) G. P. Maier et al.   SCIENCE

A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis

(2015) Leslie W. Chan et al.   Science Translational Medicine

A light-reflecting balloon catheter for atraumatic tissue defect repair

(2015) Ellen T. Roche et al.   Science Translational Medicine

Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia

(2015) Nuria Oliva et al.   Science Translational Medicine

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

(2015) Randall A. Meyer et al.   Small

Biomimetic stem cell membrane-camouflaged iron oxide nanoparticles for theranostic applications

(2015) Pei-Ying Lai et al.   RSC Advances

TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma

(2015) Martina Damo et al.   Scientific Reports

Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair

(2015) Yuhan Lee et al.   Advanced Healthcare Materials

Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy

(2015) Minjun Xuan et al.   Advanced Healthcare Materials

Nanofibrous Snake Venom Hemostat

(2015) Vivek A. Kumar et al.   ACS Biomaterials-Science & Engineering

Nanofibrous Snake Venom Hemostat

(2015) Vivek A. Kumar et al.   ACS Biomaterials Science & Engineering

Super-resolution imaging of nuclear import of adeno-associated virus in live cells

(2015) Joseph M Kelich et al.   Molecular Therapy-Methods & Clinical Development

Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment

(2014) Guoqiang Liu et al.   ACS Applied Materials & Interfaces

Platelet-like Nanoparticles: Mimicking Shape, Flexibility, and Surface Biology of Platelets To Target Vascular Injuries

(2014) Aaron C. Anselmo et al.   ACS Nano

Antigen Delivery by Lipid-Enveloped PLGA Microparticle Vaccines Mediated by in Situ Vesicle Shedding

(2014) Melissa C. Hanson et al.   BIOMACROMOLECULES

Cell rigidity and shape override CD47's "self"-signaling in phagocytosis by hyperactivating myosin-II

(2014) N. G. Sosale et al.   BLOOD

Bioinspired Bottle-Brush Polymer Exhibits Low Friction and Amontons-like Behavior

(2014) Xavier Banquy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

(2014) Daniel C Leslie et al.   NATURE BIOTECHNOLOGY

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

(2014) Yubing Sun et al.   NATURE MATERIALS

Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid

(2014) Anirudha Singh et al.   NATURE MATERIALS

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials

(2014) Ted T. Lee et al.   NATURE MATERIALS

Surface-initiated self-healing of polymers in aqueous media

(2014) B. Kollbe Ahn et al.   NATURE MATERIALS

Intravenously administered nanoparticles increase survival following blast trauma

(2014) M. M. Lashof-Sullivan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

(2014) M. M. Martino et al.   SCIENCE

An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss

(2014) B. M. Sicari et al.   Science Translational Medicine

Inflammatory Cytokines Presented from Polymer Matrices Differentially Generate and Activate DCs In Situ

(2013) Omar A. Ali et al.   ADVANCED FUNCTIONAL MATERIALS

The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination

(2013) Jennifer N. Beck et al.   BIOMATERIALS

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

A biomimetic nanosponge that absorbs pore-forming toxins

(2013) Che-Ming J. Hu et al.   Nature Nanotechnology

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue

(2013) Seung Yun Yang et al.   Nature Communications

Plasmid-Templated Shape Control of Condensed DNA-Block Copolymer Nanoparticles

(2012) Xuan Jiang et al.   ADVANCED MATERIALS

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

(2012) Alessandro Parodi et al.   Nature Nanotechnology

Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography

(2012) T. A. M. Bharat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface

(2012) H. J. Busscher et al.   Science Translational Medicine

PRINT: A Novel Platform Toward Shape and Size Specific Nanoparticle Theranostics

(2011) Jillian L. Perry et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing  -cell function

(2011) C.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self inhibition of phagocytosis: The affinity of ‘marker of self’ CD47 for SIRPα dictates potency of inhibition but only at low expression levels

(2010) Richard K. Tsai et al.   BLOOD CELLS MOLECULES AND DISEASES

Modern Uses of Electron Microscopy for Detection of Viruses

(2009) C. S. Goldsmith et al.   CLINICAL MICROBIOLOGY REVIEWS

Lubrication at Physiological Pressures by Polyzwitterionic Brushes

(2009) M. Chen et al.   SCIENCE

Stygiolobus Rod-Shaped Virus and the Interplay of Crenarchaeal Rudiviruses with the CRISPR Antiviral System

(2008) G. Vestergaard et al.   JOURNAL OF BACTERIOLOGY

Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells

(2008) Danielle S. W. Benoit et al.   NATURE MATERIALS

A biodegradable and biocompatible gecko-inspired tissue adhesive

(2008) A. Mahdavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune response to biologic scaffold materials

(2008) Stephen F. Badylak et al.   SEMINARS IN IMMUNOLOGY