Discovery of microbial natural products by activation of silent biosynthetic gene clusters

Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection

(2015) Fang Guo et al.   METABOLIC ENGINEERING

An irresistible newcomer

(2015) Gerard Wright   NATURE

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

(2015) Tilmann Weber et al.   TRENDS IN BIOTECHNOLOGY

Automated Genome Mining of Ribosomal Peptide Natural Products

(2014) Hosein Mohimani et al.   ACS Chemical Biology

Synthetic Biology Tools for Bioprospecting of Natural Products in Eukaryotes

(2014) Shiela E. Unkles et al.   CHEMISTRY & BIOLOGY

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

In silico tools for the analysis of antibiotic biosynthetic pathways

(2014) Tilmann Weber   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery

(2014) Hosein Mohimani et al.   JOURNAL OF NATURAL PRODUCTS

Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products

(2014) Daniel Krug et al.   NATURAL PRODUCT REPORTS

Reconstructing fungal natural product biosynthetic pathways

(2014) C. M. Lazarus et al.   NATURAL PRODUCT REPORTS

A talented genus

(2014) Marcel Jaspars et al.   NATURE

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Functional optimization of gene clusters by combinatorial design and assembly

(2014) Michael J Smanski et al.   NATURE BIOTECHNOLOGY

Improved Lanthipeptide Detection and Prediction for antiSMASH

(2014) Kai Blin et al.   PLoS One

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

(2014) M. R. Seyedsayamdost   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

(2014) Kazuya Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Synthetic Biology Platform Generates Novel Chemical Structures as Scaffolds for Drug Discovery

(2014) Jens Klein et al.   ACS Synthetic Biology

Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products

(2014) Marnix H. Medema et al.   PLoS Computational Biology

Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074

(2014) Carlos Olano et al.   Microbial Biotechnology

Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors

(2013) Michelle Schorn et al.   ACS Chemical Biology

Cloning and Heterologous Expression of the Thioviridamide Biosynthesis Gene Cluster from Streptomyces olivoviridis

(2013) Masumi Izawa et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic FungusAspergillus fumigatus

(2013) Claudia C. König et al.   CHEMBIOCHEM

Imaging Mass Spectrometry of a Coral Microbe Interaction with Fungi

(2013) Wilna J. Moree et al.   JOURNAL OF CHEMICAL ECOLOGY

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

(2013) Gregory L. Challis   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Discovery and Synthetic Refactoring of Tryptophan Dimer Gene Clusters from the Environment

(2013) Fang-Yuan Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural product isolation – how to get from biological material to pure compounds

(2013) Franz Bucar et al.   NATURAL PRODUCT REPORTS

From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes

(2013) Kyung Bo Kim et al.   NATURAL PRODUCT REPORTS

Using NMR to identify and characterize natural products

(2013) Rosemary C. Breton et al.   NATURAL PRODUCT REPORTS

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

BAGEL3: automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides

(2013) Auke J. van Heel et al.   NUCLEIC ACIDS RESEARCH

Structurally Diverse Chaetophenol Productions Induced by Chemically Mediated Epigenetic Manipulation of Fungal Gene Expression

(2013) Teigo Asai et al.   ORGANIC LETTERS

Classification of the Adenylation and Acyl-Transferase Activity of NRPS and PKS Systems Using Ensembles of Substrate Specific Hidden Markov Models

(2013) Barzan I. Khayatt et al.   PLoS One

Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster

(2013) Adam C. Jones et al.   PLoS One

Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

(2013) J. G. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster

(2013) John D. Sidda et al.   Chemical Science

Antiterminator-Mediated Unveiling of Cryptic Polythioamides in an Anaerobic Bacterium

(2012) Swantje Behnken et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

(2012) Kozo Ochi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Chemical Perturbation of Secondary Metabolism Demonstrates Important Links to Primary Metabolism

(2012) Arryn Craney et al.   CHEMISTRY & BIOLOGY

Natural Products As Sources for New Pesticides

(2012) Charles L. Cantrell et al.   JOURNAL OF NATURAL PRODUCTS

Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters

(2012) Dimitris Kallifidas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Terpenoid synthase structures: a so far incomplete view of complex catalysis

(2012) Yang Gao et al.   NATURAL PRODUCT REPORTS

A genomic approach to the cryptic secondary metabolome of the anaerobic world

(2012) Anne-Catrin Letzel et al.   NATURAL PRODUCT REPORTS

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Regulation of fungal secondary metabolism

(2012) Axel A. Brakhage   NATURE REVIEWS MICROBIOLOGY

Interkingdom metabolic transformations captured by microbial imaging mass spectrometry

(2012) W. J. Moree et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

Transcriptional regulatory elements in fungal secondary metabolism

(2011) Wenbing Yin et al.   JOURNAL OF MICROBIOLOGY

Metabolites from the Induced Expression of Cryptic Single Operons Found in the Genome of Burkholderia pseudomallei

(2011) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler

(2011) Zengyi Shao et al.   Molecular BioSystems

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

Fidaxomicin versus Vancomycin forClostridium difficileInfection

(2011) Thomas J. Louie et al.   NEW ENGLAND JOURNAL OF MEDICINE

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Acyldepsipeptide HDAC Inhibitor Production Induced inBurkholderia thailandensis

(2011) John B. Biggins et al.   ORGANIC LETTERS

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum

(2010) Thorger Lincke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mycolic Acid-Containing Bacteria Induce Natural-Product Biosynthesis inStreptomycesSpecies

(2010) Hiroyasu Onaka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species

(2010) D. Nichols et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR

(2010) Jeffrey H. Kim et al.   BIOPOLYMERS

Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms

(2010) Yi-Ming Chiang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

SMURF: Genomic mapping of fungal secondary metabolite clusters

(2010) Nora Khaldi et al.   FUNGAL GENETICS AND BIOLOGY

Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans

(2010) Kirstin Scherlach et al.   JOURNAL OF ANTIBIOTICS

Rare earth elements activate the secondary metabolite–biosynthetic gene clusters in Streptomyces coelicolor A3(2)

(2010) Yukinori Tanaka et al.   JOURNAL OF ANTIBIOTICS

Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1

(2010) Nancy L McKenzie et al.   JOURNAL OF ANTIBIOTICS

Characterization and Manipulation of the Pathway-Specific Late Regulator AlpW Reveals Streptomyces ambofaciens as a New Producer of Kinamycins

(2010) R. Bunet et al.   JOURNAL OF BACTERIOLOGY

E. coli NusG Inhibits Backtracking and Accelerates Pause-Free Transcription by Promoting Forward Translocation of RNA Polymerase

(2010) Kristina M. Herbert et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemical Epigenetics Alters the Secondary Metabolite Composition of Guttate Excreted by an Atlantic-Forest-Soil-DerivedPenicillium citreonigrum

(2010) Xiaoru Wang et al.   JOURNAL OF NATURAL PRODUCTS

Genome Mining inStreptomyces avermitilis: Cloning and Characterization of SAV_76, the Synthase for a New Sesquiterpene, Avermitilol

(2010) Wayne K. W. Chou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

(2010) Keishi Ishida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)

(2010) M. Gottelt et al.   MICROBIOLOGY-SGM

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

SBSPKS: structure based sequence analysis of polyketide synthases

(2010) Swadha Anand et al.   NUCLEIC ACIDS RESEARCH

CDD: a Conserved Domain Database for the functional annotation of proteins

(2010) A. Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strategies for the Discovery of New Natural Products by Genome Mining

(2009) Malek Zerikly et al.   CHEMBIOCHEM

The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis

(2009) Daniel Oves-Costales et al.   CHEMICAL COMMUNICATIONS

Microbial drug discovery: 80 years of progress

(2009) Arnold L Demain et al.   JOURNAL OF ANTIBIOTICS

A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, inAspergillus nidulans

(2009) Yi-Ming Chiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

(2009) Robert H. Cichewicz   NATURAL PRODUCT REPORTS

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

Chromatin-level regulation of biosynthetic gene clusters

(2009) Jin Woo Bok et al.   Nature Chemical Biology

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

(2009) V. Schroeckh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases

(2008) David H. Kwan et al.   CHEMISTRY & BIOLOGY

Control of bacterial transcription, translation and replication by (p)ppGpp

(2008) Anjana Srivatsan et al.   CURRENT OPINION IN MICROBIOLOGY

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY

DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

(2008) Zengyi Shao et al.   NUCLEIC ACIDS RESEARCH

Epigenetic remodeling of the fungal secondary metabolome

(2008) Russell B. Williams et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

(2008) Jon C. Henrikson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining

(2008) C. Corre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism

(2008) O. Bayram et al.   SCIENCE