Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo

Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling

(2018) Wen Zhang et al.   ACTA PHARMACOLOGICA SINICA

Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 signaling pathway

(2018) Ying Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway

(2018) Meng Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sex differences in the evaluation and treatment of acute ischaemic stroke

(2018) Cheryl Bushnell et al.   LANCET NEUROLOGY

Advances in stroke pharmacology

(2018) Zhenhua Zhou et al.   PHARMACOLOGY & THERAPEUTICS

Prediction of myocardial infarction, stroke and cardiovascular mortality with urinary biomarkers of oxidative stress: Results from a large cohort study

(2018) Yang Xuan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Epidemiology, aetiology, and management of ischaemic stroke in young adults

(2018) Merel S Ekker et al.   LANCET NEUROLOGY

Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways

(2018) Qiu Liu et al.   Molecular Medicine Reports

Effects of bilobalide, ginkgolide B and picrotoxinin on GABA A receptor modulation by structurally diverse positive modulators

(2017) Chiu Chin Ng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo

(2017) Yan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability

(2017) Xu Zhou et al.   Oncotarget

PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice

(2016) Nanhui Ye et al.   Biomolecules & Therapeutics

Ginkgolides and bilobalide protect BV2 microglia cells against OGD/reoxygenation injury by inhibiting TLR2/4 signaling pathways

(2016) Jian-Ming Zhou et al.   CELL STRESS & CHAPERONES

Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p

(2016) Yi Zhi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice

(2016) Zhao-Ma Shu et al.   CNS Neuroscience & Therapeutics

GABAA receptor cysteinyl mutants and the ginkgo terpenoid lactones bilobalide and ginkgolides

(2016) Chiu Chin Ng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke

(2016) Shuai Jiang et al.   MOLECULAR NEUROBIOLOGY

Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke

(2016) Rongrong Zhang et al.   MOLECULAR NEUROBIOLOGY

Anti-Inflammatory and Neuroprotective Effects of Triptolide via the NF-κB Signaling Pathway in a Rat MCAO Model

(2015) Shi Bai et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Ginkgolide B increases hydrogen sulfide and protects against endothelial dysfunction in diabetic rats

(2015) Guo-Guang Wang et al.   CROATIAN MEDICAL JOURNAL

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of Nrf2 in oxidative stress-induced endothelial injuries

(2015) B. Chen et al.   JOURNAL OF ENDOCRINOLOGY

Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats

(2015) Hong-Xia Pei et al.   PHARMACOLOGY

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

(2014) Mingjin Jiang et al.   Journal of Neuroinflammation

Opposing Effects of Glucose on Stroke and Reperfusion Injury

(2014) Nathaniel M. Robbins et al.   STROKE

Cardiovascular Events Associated With Smoking Cessation Pharmacotherapies

(2013) Edward J. Mills et al.   CIRCULATION

Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities

(2013) Ramon Rodrigo et al.   CNS & Neurological Disorders-Drug Targets

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Nrf2 in protection against acute kidney injury

(2013) Luke M. Shelton et al.   KIDNEY INTERNATIONAL

Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia

(2013) WEI-ZU LI et al.   Molecular Medicine Reports

Protective effects of bilobalide on Aβ25–35 induced learning and memory impairments in male rats

(2013) Yanyan Yin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Oxidative stress – assassin behind the ischemic stroke

(2012) Hanumanthappa Pradeep et al.   FOLIA NEUROPATHOLOGICA

Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury

(2012) Silvia Manzanero et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo

(2011) Dorothee Lang et al.   BRAIN RESEARCH

Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia

(2011) Menghao Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke

(2011) Alessio Alfieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

(2009) C. L. Allen et al.   International Journal of Stroke

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE