Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression

Cytokine secretion and the risk of depression development in patients with connective tissue diseases

(2019) Bogna Grygiel‐Górniak et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder

(2019) Kenny L. Chan et al.   PHYSIOLOGY

The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

(2019) Sachchida Nand Rai et al.   NEUROTOXICITY RESEARCH

Neuroinflammation and cognition across psychiatric conditions

(2019) Célia Fourrier et al.   CNS SPECTRUMS

Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice

(2018) Maocai Zhai et al.   ATHEROSCLEROSIS

Ursolic acid improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-induced rats

(2018) Hui-lin Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Ursolic acid ameliorates oxidative stress, inflammation and fibrosis in diabetic cardiomyopathy rats

(2018) Xu-tao Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Imaging the Role of Inflammation in Mood and Anxiety-related Disorders

(2018) Jennifer C. Felger   Current Neuropharmacology

The role of oxidative stress in anxiety disorder: cause or consequence?

(2018) Alessandra das Graças Fedoce et al.   FREE RADICAL RESEARCH

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Pharmacology of Rosmarinic and Salvianolic Acids: Potential Seeds for Alzheimer’s and Vascular Dementia Drugs

(2018) Solomon Habtemariam   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial Inflammasome Activation in Penetrating Ballistic-Like Brain Injury

(2018) Stephanie W. Lee et al.   JOURNAL OF NEUROTRAUMA

The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse

(2018) Sudhanshu Sahu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ursolic acid in health and disease

(2018) Dae Yun Seo et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Oral supplementation with ursolic acid ameliorates sepsis-induced acute kidney injury in a mouse model by inhibiting oxidative stress and inflammatory responses

(2018) Zhenyu Zhang et al.   Molecular Medicine Reports

Ursolic Acid Attenuates Atherosclerosis in ApoE−/− Mice: Role of LOX-1 Mediated by ROS/NF-κB Pathway

(2018) Qiu Li et al.   MOLECULES

Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects

(2018) Solomon Habtemariam   MOLECULES

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs

(2018) Solomon Habtemariam   Neural Regeneration Research

Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice

(2018) Dorota Nieoczym et al.   NEUROCHEMICAL RESEARCH

Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway

(2018) Er-Min Wang et al.   MEDICAL SCIENCE MONITOR

Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB Pathway

(2018) Yanzhe Wang et al.   Frontiers in Neurology

Alzheimer’s Disease (AD) therapeutics - 2: Beyond amyloid - re-defining AD and its causality to discover effective therapeutics

(2018) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

Ursolic acid a promising candidate in the therapeutics of breast cancer: Current status and future implications

(2018) Javed Iqbal et al.   BIOMEDICINE & PHARMACOTHERAPY

Synergistic action of ursolic acid and metformin in experimental model of insulin resistance and related behavioral alterations

(2018) Ashish Mourya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ursolic acid stimulates UCP2 expression and protects H9c2 cells from hypoxia-reoxygenation injury via p38 signaling

(2018) Min Chen et al.   JOURNAL OF BIOSCIENCES

Ursolic acid alleviates inflammation and against diabetes‑induced nephropathy through TLR4‑mediated inflammatory pathway

(2018) Jian Li et al.   Molecular Medicine Reports

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

(2018) Lige Leng et al.   NEURON

Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response

(2018) Shariful A. Syed et al.   NEURON

An anti-inflammatory diet as a potential intervention for depressive disorders: A systematic review and meta-analysis

(2018) Katie Tolkien et al.   CLINICAL NUTRITION

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Spencer L James et al.   LANCET NEUROLOGY

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies

(2018) Piyoosh Sharma et al.   PROGRESS IN NEUROBIOLOGY

Ursolic and oleanolic acid derivatives with cholinesterase inhibiting potential

(2018) Anne Loesche et al.   BIOORGANIC CHEMISTRY

Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

(2017) Taiwo Olayemi Elufioye et al.   Evidence-based Complementary and Alternative Medicine

Animal inflammation-based models of depression and their application to drug discovery

(2017) Li Ma et al.   Expert Opinion on Drug Discovery

Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation

(2017) Alejandra M. Ramírez-Rodríguez et al.   JOURNAL OF MEDICINAL FOOD

Protective Effects of Caffeic Acid and the Alzheimer's Brain: An Update

(2017) Solomon Habtemariam   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Ursolic Acid, a Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation-Associated Downstream Signal Transduction

(2017) Xiaoyao Ma et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes

(2017) Chengyue Zhang et al.   MOLECULAR PHARMACEUTICS

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review

(2017) Carlos K. Katashima et al.   Obesity Reviews

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

(2017) Lucian Hritcu et al.   Oxidative Medicine and Cellular Longevity

Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2

(2017) Ana B. Ramos-Hryb et al.   Pharmacological Reports

Radioprotective effect of ursolic acid in radiation-induced impairment of neurogenesis, learning and memory in adolescent BALB/c mouse

(2017) Feng Ru Tang et al.   PHYSIOLOGY & BEHAVIOR

Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways

(2017) Li Lin et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Microglial Activation in Traumatic Brain Injury

(2017) Cornelius K. Donat et al.   Frontiers in Aging Neuroscience

Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury

(2017) Anwarul Hasan et al.   Frontiers in Neurology

Ursolic acid attenuates beta-amyloid-induced memory impairment in mice

(2016) Wenna Liang et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Ursolic acid regulates aging process through enhancing of metabolic sensor proteins level

(2016) Soroush Alaghehband Bahrami et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effects of ursolic acid against hepatotoxicity and endothelial dysfunction in mice with chronic high choline diet consumption

(2016) Dongyu Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

(2016) Leide dos Santos Picanç et al.   CURRENT MEDICINAL CHEMISTRY

Rutin as a Natural Therapy for Alzheimer’s Disease: Insights into its Mechanisms of Action

(2016) Solomon Habtemariam   CURRENT MEDICINAL CHEMISTRY

GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents fromArtemisia indicaLinn

(2016) Imran Khan et al.   Evidence-based Complementary and Alternative Medicine

The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s Disease

(2016) Solomon Habtemariam   Evidence-based Complementary and Alternative Medicine

Effect of ursolic acid in attenuating chronic constriction injury-induced neuropathic pain in rats

(2016) Rafia A. Bhat et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model

(2016) Sachchida Nand Rai et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis

(2016) Shuilong Leng et al.   JOURNAL OF LIPID RESEARCH

Renoprotective effects of ursolic acid on ischemia/reperfusion-induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF-κB activities

(2016) Jun Peng et al.   Molecular Medicine Reports

Ursolic acid prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPARα

(2016) YANAN ZHANG et al.   Molecular Medicine Reports

Ursolic Acid Ameliorates Early Brain Injury After Experimental Traumatic Brain Injury in Mice by Activating the Nrf2 Pathway

(2016) Hui Ding et al.   NEUROCHEMICAL RESEARCH

Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury

(2016) Yanzhe Wang et al.   Drug Design Development and Therapy

Molecular Basis of Klotho: From Gene to Function in Aging

(2015) Yuechi Xu et al.   ENDOCRINE REVIEWS

Ursolic acid enhances pentobarbital-induced sleeping behaviors via GABAergic neurotransmission in mice

(2015) Se Jin Jeon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anxiolytic-like effects of ursolic acid in mice

(2015) André R.S. Colla et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Suppression of oxidative stress and improvement of liver functions in mice by ursolic acid via LKB1-AMP-activated protein kinase signaling

(2015) Yongbin Yang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Ursolic acid improves survival and attenuates lung injury in septic rats induced by cecal ligation and puncture

(2015) Zhansheng Hu et al.   JOURNAL OF SURGICAL RESEARCH

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

(2015) Danielle R. Bruns et al.   Oxidative Medicine and Cellular Longevity

Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway

(2015) Jie-Qiong Ma et al.   Clinics and Research in Hepatology and Gastroenterology

Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress

(2015) Jian-Shuang Li et al.   Food & Function

Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation

(2014) Seung-ye Baek et al.   ACTA PHARMACOLOGICA SINICA

Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway

(2014) Jie-Qiong Ma et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-κB activities

(2014) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ursolic acid alleviates early brain injury after experimental subarachnoid hemorrhage by suppressing TLR4-mediated inflammatory pathway

(2014) Tingting Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ursolic Acid Isolated from the Seed of Cornus officinalis Ameliorates Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to Toll-like Receptor 4 on Macrophages

(2014) Se-Eun Jang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

p-Coumaric Acid and Ursolic Acid from Corni fructus Attenuated β-Amyloid25–35-Induced Toxicity through Regulation of the NF-κB Signaling Pathway in PC12 Cells

(2014) Jeong-Hyun Yoon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease

(2014) Georgia S. Gaki et al.   NEUROMOLECULAR MEDICINE

Ursolic acid reduces oxidative stress to alleviate early brain injury following experimental subarachnoid hemorrhage

(2014) Tingting Zhang et al.   NEUROSCIENCE LETTERS

Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice

(2014) André R.S. Colla et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Therapeutic Role of Ursolic Acid on Ameliorating Hepatic Steatosis and Improving Metabolic Disorders in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Rats

(2014) Songtao Li et al.   PLoS One

Evidence of Inflammatory System Involvement in Parkinson’s Disease

(2014) Yinxia Chao et al.   Biomed Research International

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Effects of artesunate and ursolic acid on hyperlipidemia and its complications in rabbit

(2013) Y.L. Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism

(2013) Jazmín Verano et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ursolic acid improves domoic acid-induced cognitive deficits in mice

(2013) Dong-mei Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFκB pathway in streptozocin-induced diabetic rats

(2012) Min Xiang et al.   ARCHIVES OF PHARMACAL RESEARCH

Monoamine Oxidase and Dopamine β-Hydroxylase Inhibitors from the Fruits of Gardenia jasminoides

(2012) Ji-Ho Kim et al.   Biomolecules & Therapeutics

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma

(2012) Seung-Hyung Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats

(2012) Jian-hua Liu et al.   Evidence-based Complementary and Alternative Medicine

Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model

(2012) Xiangjun Chen et al.   Immunotherapy

Neuroprotection by Silencing iNOS Expression in a 6-OHDA Model of Parkinson’s Disease

(2012) Min Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells

(2012) Seung-Young Hong et al.   MOLECULES

Oxidative Stress in Genetic Mouse Models of Parkinson’s Disease

(2012) Mustafa Varçin et al.   Oxidative Medicine and Cellular Longevity

Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system

(2012) D.G. Machado et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis

(2011) Sarah L. Ullevig et al.   ATHEROSCLEROSIS

Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain

(2011) Gislaine Z. Réus et al.   BEHAVIOURAL BRAIN RESEARCH

Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

(2011) Jun Lu et al.   BRAIN BEHAVIOR AND IMMUNITY

Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice

(2011) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

A High Content Drug Screen Identifies Ursolic Acid as an Inhibitor of Amyloid β Protein Interactions with Its Receptor CD36

(2011) Kim Wilkinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

(2011) Yong-Jian Wang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Oxidative Stress in Parkinson's Disease

(2010) Chun Zhou et al.   Annals of the New York Academy of Sciences

Ursolic Acid Attenuates D-Galactose-Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF- B Pathway Activation

(2010) J. Lu et al.   CEREBRAL CORTEX

The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models

(2010) Suk-Yun Kang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test

(2009) Patrícia S. Brocardo et al.   BEHAVIOURAL BRAIN RESEARCH

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia

(2009) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-κB in MPTP-treated mice: implication in Parkinson’s disease

(2009) S. Karunakaran et al.   JOURNAL OF NEUROCHEMISTRY

Bioassay-guided fractionation of lemon balm (Melissa officinalisL.) using anin vitromeasure of GABA transaminase activity

(2009) Rosalie Awad et al.   PHYTOTHERAPY RESEARCH

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

Ursolic acid inhibits IL-1β or TNF-α-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-ζ and downregulating the MMP-9 expression

(2008) Hsiu-Chen Huang et al.   MOLECULAR CARCINOGENESIS