ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis

ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb

(2019) Erik A. Blackwood et al.   CIRCULATION RESEARCH

Intracellular Lipopolysaccharide Sensing as a Potential Therapeutic Target for Sepsis

(2019) Anja Pfalzgraff et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis

(2019) Elisa Di Pasquale et al.   EMBO Molecular Medicine

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

(2019) Magda R Hamczyk et al.   EMBO Molecular Medicine

The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes

(2019) David A. Sallman et al.   BLOOD

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond

(2019) Nicolas Albornoz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological targeting of the unfolded protein response for disease intervention

(2019) Claudio Hetz et al.   Nature Chemical Biology

OUP accepted manuscript

(2018)   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets

(2018) Susana Rovira-Llopis et al.   ANTIOXIDANTS & REDOX SIGNALING

The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation

(2018) Gonzalo J. Martínez et al.   ATHEROSCLEROSIS

Inflammation and atherosclerosis: Cardiovascular evaluation in patients with autoimmune diseases

(2018) Ricardo O. Escárcega et al.   AUTOIMMUNITY REVIEWS

Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux

(2018) Liang Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammation-induced mTORC2-Akt-mTORC1 signaling promotes macrophage foam cell formation

(2018) Dipanjan Banerjee et al.   BIOCHIMIE

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis and Atherogenesis

(2018) Marit Westerterp et al.   CIRCULATION

Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the multi-ethnic study of atherosclerosis (MESA)

(2018) Matthew J Budoff et al.   EUROPEAN HEART JOURNAL

ROS signaling and ER stress in cardiovascular disease

(2018) Cristhiaan D. Ochoa et al.   MOLECULAR ASPECTS OF MEDICINE

Inflammasome biology, molecular pathology and therapeutic implications

(2018) Fawaz Awad et al.   PHARMACOLOGY & THERAPEUTICS

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

ER Proteostasis Control of Neuronal Physiology and Synaptic Function

(2018) Gabriela Martínez et al.   TRENDS IN NEUROSCIENCES

Endoplasmic Reticulum Stress Affects Lipid Metabolism in Atherosclerosis Via CHOP Activation and Over-Expression of miR-33

(2018) Yan Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms

(2018) Arvin B. Tam et al.   DEVELOPMENTAL CELL

Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation

(2018) Marianne de la Roche et al.   JOURNAL OF CELL BIOLOGY

Sterol regulatory element binding protein (SREBP) -1 mediates oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation through NLRP3 inflammasome activation

(2018) Johnna F. Varghese et al.   CELLULAR SIGNALLING

Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

(2018) Chuansheng Guo et al.   IMMUNITY

Selective p38α MAP kinase/MAPK14 inhibition in enzymatically modified LDL-stimulated human monocytes: implications for atherosclerosis

(2017) Fei Cheng et al.   FASEB JOURNAL

Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response

(2017) Irina Grechowa et al.   FASEB JOURNAL

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway

(2017) Hyo Jeong Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

(2017) Jin Kyung Kim et al.   IMMUNOLOGY AND CELL BIOLOGY

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis

(2017) Meng-Yu Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction

(2017) S. Samuel Weigt et al.   JOURNAL OF CLINICAL INVESTIGATION

NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis

(2017) Andrey Lozhkin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice

(2017) Renqing Wang et al.   LABORATORY INVESTIGATION

Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-κB Pathways

(2017) Chencheng Feng et al.   Oxidative Medicine and Cellular Longevity

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

(2017) Ozlem Tufanli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models

(2017) Meichun Zeng et al.   TOXICOLOGY LETTERS

Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy

(2017) Lars Plate et al.   TRENDS IN CELL BIOLOGY

Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy

(2017) Wenming Li et al.   Nature Communications

Endothelial cells, endoplasmic reticulum stress and oxysterols

(2017) F. Luchetti et al.   Redox Biology

Implication of REDD1 in the activation of inflammatory pathways

(2017) Faustine Pastor et al.   Scientific Reports

Endoplasmic Reticulum–Associated Degradation and Lipid Homeostasis

(2016) Julian Stevenson et al.   Annual Review of Nutrition

Inhibition of Orai1 Store–Operated Calcium Channel Prevents Foam Cell Formation and AtherosclerosisSignificance

(2016) Si-Jia Liang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Jnk1Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null MiceHighlights

(2016) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein quality control at the endoplasmic reticulum

(2016) K. McCaffrey et al.   Essays in Biochemistry

Associations of polymorphisms inTXNIPand gene-environment interactions with the risk of coronary artery disease in a Chinese Han population

(2016) Xue-bin Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Calcium signalling and ER stress in insulin resistance and atherosclerosis

(2016) L. Ozcan et al.   JOURNAL OF INTERNAL MEDICINE

Basic Mechanisms in Atherosclerosis: The Role of Calcium

(2016) Aimilios Kalampogias et al.   Medicinal Chemistry

A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways

(2016) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Endoplasmic reticulum proteostasis in hepatic steatosis

(2016) Andrei Baiceanu et al.   Nature Reviews Endocrinology

Improving the CAC Score by Addition of Regional Measures of Calcium Distribution

(2016) Michael J. Blaha et al.   JACC-Cardiovascular Imaging

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

(2016) Geena Paramel Varghese et al.   Journal of the American Heart Association

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular RemodelingSignificance

(2015) Stephen P. Gray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice

(2015) Chang Hyun Byon et al.   ATHEROSCLEROSIS

Potential therapeutic effects of mTOR inhibition in atherosclerosis

(2015) Ammar Kurdi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

Involvement of the IRE1α-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases

(2015) Rong Wu et al.   DNA AND CELL BIOLOGY

Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque

(2015) Abed Janoudi et al.   EUROPEAN HEART JOURNAL

Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis

(2015) Andreas Koeberle et al.   FASEB JOURNAL

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells

(2015) Junna Song et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

mTOR inhibition: A promising strategy for stabilization of atherosclerotic plaques

(2014) Wim Martinet et al.   ATHEROSCLEROSIS

AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response

(2014) Hongliang Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

(2014) Nicola J. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting the unfolded protein response, XBP1, and the NLRP3 inflammasome in fibrosis and cancer

(2014) Beth Overley-Adamson et al.   CANCER BIOLOGY & THERAPY

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The Impact of Intermittent and Repetitive Cold Stress Exposure on Endoplasmic Reticulum Stress and Instability of Atherosclerotic Plaques

(2014) Ming-Xiang Dai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Endothelial dysfunction

(2014) Zhen Chen et al.   CURRENT OPINION IN LIPIDOLOGY

mTOR Enhances Foam Cell Formation by Suppressing the Autophagy Pathway

(2014) Xiaochuang Wang et al.   DNA AND CELL BIOLOGY

A Combined “Omics” Approach Identifies N-Myc Interactor as a Novel Cytokine-induced Regulator of IRE1α Protein and c-Jun N-terminal Kinase in Pancreatic Beta Cells

(2014) Flora Brozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

(2014) Masahiro Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway

(2014) Xu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1β Production

(2014) Kuo-Feng Hua et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

(2014) Fei Zheng et al.   MEDIATORS OF INFLAMMATION

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

(2014) S Win et al.   Cell Death & Disease

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

(2014) S R Kim et al.   Cell Death & Disease

Hepatoprotective role of Sestrin2 against chronic ER stress

(2014) Hwan-Woo Park et al.   Nature Communications

HIV, Inflammation, and Calcium in Atherosclerosis

(2013) Sadeep Shrestha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy

(2013) Hadi Digaleh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Atheroprone Flow Activation of the Sterol Regulatory Element Binding Protein 2 and Nod-Like Receptor Protein 3 Inflammasome Mediates Focal Atherosclerosis

(2013) Jun-ichi Abe et al.   CIRCULATION

Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

(2013) Han Xiao et al.   CIRCULATION

Membrane lipid saturation activates IRE1α without inducing clustering

(2013) Yuto Kitai et al.   GENES TO CELLS

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

(2013) Sena Kim et al.   Innate Immunity

Increased mTORC1 activity contributes to atherosclerosis in apolipoprotein E knockout mice and in vascular smooth muscle cells

(2013) Kun Ling Ma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Knockdown of mTOR by lentivirus-mediated RNA interference suppresses atherosclerosis and stabilizes plaques via a decrease of macrophages by autophagy in apolipoprotein E-deficient mice

(2013) XIAOCHUANG WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inflammation and Atherosclerosis—Revisited

(2013) Sadip Pant et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The UPR in atherosclerosis

(2013) Alex X. Zhou et al.   Seminars in Immunopathology

Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response

(2013) Shun Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Everolimus Triggers Cytokine Release by Macrophages

(2012) Wim Martinet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HMGB1 Promotes the Synthesis of Pro-IL-1β and Pro-IL-18 by Activation of p38 MAPK and NF-κB Through Receptors for Advanced Glycation End-products in Macrophages

(2012) Qiang He et al.   Asian Pacific Journal of Cancer Prevention

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathway

(2011) H Kato et al.   CELL DEATH AND DIFFERENTIATION

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses

(2011) Junhong Gao et al.   CIRCULATION

Constitutive Role for IRE1α-XBP1 Signaling Pathway in the Insulin-Mediated Hepatic Lipogenic Program

(2011) Jie Ning et al.   ENDOCRINOLOGY

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

BCL-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress

(2010) Girija Dasmahapatra et al.   CANCER BIOLOGY & THERAPY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

(2010) Y J Kang et al.   CELL DEATH AND DIFFERENTIATION

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Conditions of endoplasmic reticulum stress stimulate lipid droplet formation inSaccharomyces cerevisiae

(2009) Weihua Fei et al.   BIOCHEMICAL JOURNAL

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SR/ER–mitochondrial local communication: Calcium and ROS

(2009) György Csordás et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

Intersection of the unfolded protein response and hepatic lipid metabolism

(2009) Ann-Hwee Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis

(2009) Mete Civelek et al.   CIRCULATION RESEARCH

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

(2009) Jessica Chu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NRF-1 is the major transcription factor regulating the expression of the human TOMM34 gene

(2008) José R. Blesa et al.   Biochemistry and Cell Biology

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

(2008) InKi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Everolimus Inhibits Monocyte/Macrophage Migration in Vitro and Their Accumulation in Carotid Lesions of Cholesterol-Fed Rabbits

(2008) R. Baetta et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Role of SERCA1 Truncated Isoform in the Proapoptotic Calcium Transfer from ER to Mitochondria during ER Stress

(2008) Mounia Chami et al.   MOLECULAR CELL

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

(2008) E. Bobrovnikova-Marjon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Estradiol Stimulates Transcription of Nuclear Respiratory Factor-1 and Increases Mitochondrial Biogenesis

(2007) Kathleen A. Mattingly et al.   MOLECULAR ENDOCRINOLOGY