Halogenating Enzymes for Active Agent Synthesis: First Steps Are Done and Many Have to Follow

Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus

(2019) Yongjian Qiao et al.   JOURNAL OF NATURAL PRODUCTS

Chlorinated Natural Products and Related Halogenases

(2019) Jia Zeng et al.   ISRAEL JOURNAL OF CHEMISTRY

Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination

(2019) Mohamed Ismail et al.   ADVANCED SYNTHESIS & CATALYSIS

Gram-Scale, Cheap, and Eco-Friendly Iron-Catalyzed Cross-Coupling between Alkyl Grignard Reagents and Alkenyl or Aryl Halides

(2019) Gérard Cahiez et al.   ORGANIC LETTERS

Cyclization of RGD Peptides by Suzuki–Miyaura Cross-Coupling

(2019) Isabell Kemker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound

(2019) Takahiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A marine viral halogenase that iodinates diverse substrates

(2019) Danai S. Gkotsi et al.   Nature Chemistry

Iron-Catalyzed Cross-Couplings in the Synthesis of Pharmaceuticals: In Pursuit of Sustainability

(2018) Aleksandra Piontek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic fluorination of biotin and tetrazine conjugates for pre-targeting approaches to PET imaging

(2018) Phillip T Lowe et al.   CHEMBIOCHEM

Photochemically Driven Biocatalysis of Halogenases for the Green Production of Chlorinated Compounds

(2018) Lea Schroeder et al.   ChemCatChem

A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination

(2018) Pia R. Neubauer et al.   PLoS One

A coupled chlorinase–fluorinase system with a high efficiency of trans-halogenation and a shared substrate tolerance

(2018) H. Sun et al.   CHEMICAL COMMUNICATIONS

Iron- or Palladium Catalyzed Reaction Cascades Merging Cycloisomerization and Cross Coupling Chemistry

(2018) Alois Fürstner et al.   CHEMISTRY-A EUROPEAN JOURNAL

Aranazoles: Extensively Chlorinated Nonribosomal Peptide–Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339

(2018) Philipp Moosmann et al.   ORGANIC LETTERS

Enzymatic halocyclization of allenic alcohols and carboxylates: a biocatalytic entry to functionalized O-heterocycles

(2017) J. Naapuri et al.   GREEN CHEMISTRY

Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist

(2017) Salette Martinez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling

(2017) Mary C. Andorfer et al.   ACS Catalysis

Novel mechanism of metabolic co-regulation coordinates the biosynthesis of secondary metabolites in Pseudomonas protegens

(2017) Qing Yan et al.   eLife

Enzymatic halogenation and oxidation using an alcohol oxidase-vanadium chloroperoxidase cascade

(2017) Andrada But et al.   Molecular Catalysis

Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules

(2016) Matthew L. Hillwig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

(2016) Veit Weichold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme

(2016) Stephen Thompson et al.   BIOORGANIC CHEMISTRY

Aliphatic Halogenase Enables Late-Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity

(2016) Qin Zhu et al.   CHEMBIOCHEM

The Fluorine Gauche Effect: A Brief History

(2016) Christian Thiehoff et al.   ISRAEL JOURNAL OF CHEMISTRY

Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases

(2016) Maria Laura Mascotti et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

(2016) Andrew J Mitchell et al.   Nature Chemical Biology

Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase–thioesterase enzyme pair

(2016) Abrahim El Gamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Biocatalytic Aza-Achmatowicz Reaction

(2016) Elena Fernández-Fueyo et al.   ACS Catalysis

Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

(2016) Long Ma et al.   RSC Advances

The Important Role of Halogen Bond in Substrate Selectivity of Enzymatic Catalysis

(2016) Shuiqin Jiang et al.   Scientific Reports

Chemoenzymatic Halogenation of Phenols by using the Haloperoxidase fromCurvularia inaequalis

(2015) Elena Fernández-Fueyo et al.   ChemCatChem

Vanadium haloperoxidases: From the discovery 30 years ago to X-ray crystallographic and V K-edge absorption spectroscopic studies

(2015) C. Leblanc et al.   COORDINATION CHEMISTRY REVIEWS

Caldariomyces fumago DSM1256 Contains Two Chloroperoxidase Genes, Both Encoding Secreted and Active Enzymes

(2015) Markus Buchhaupt et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes

(2015) Sarah A. Shepherd et al.   Chemical Science

Production of iodine-124 and its applications in nuclear medicine

(2014) Ana Maria S. Braghirolli et al.   APPLIED RADIATION AND ISOTOPES

Identification of Fluorinases fromStreptomycessp MA37,Norcardia brasiliensis, andActinoplanessp N902-109 by Genome Mining

(2014) Hai Deng et al.   CHEMBIOCHEM

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

(2014) David O’Hagan et al.   CHEMICAL REVIEWS

Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

(2014) Vinayak Agarwal et al.   Nature Chemical Biology

A new family of iron-dependent halogenases acts on freestanding substrates

(2014) Matthew L Hillwig et al.   Nature Chemical Biology

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

(2014) Megan L Matthews et al.   Nature Chemical Biology

Insights into enzymatic halogenation from computational studies

(2014) Hans M. Senn   Frontiers in Chemistry

Scope and potential of halogenases in biosynthetic applications

(2013) Duncan RM Smith et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Enzymatic halogenation of the phenolic monoterpenes thymol and carvacrol with chloroperoxidase

(2013) Laura Getrey et al.   GREEN CHEMISTRY

Halogen Interactions in Protein–Ligand Complexes: Implications of Halogen Bonding for Rational Drug Design

(2013) Suman Sirimulla et al.   Journal of Chemical Information and Modeling

Halogen Bond: Its Role beyond Drug–Target Binding Affinity for Drug Discovery and Development

(2013) Zhijian Xu et al.   Journal of Chemical Information and Modeling

Catalysis by Desolvation: The Catalytic Prowess of SAM-Dependent Halide-Alkylating Enzymes

(2013) Danielle C. Lohman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

(2013) Shaun D. Wong et al.   NATURE

Halogen bonding for rational drug design and new drug discovery

(2012) Yunxiang Lu et al.   Expert Opinion on Drug Discovery

Randomized Phase II Study of Dacomitinib (PF-00299804), an Irreversible Pan–Human Epidermal Growth Factor Receptor Inhibitor, Versus Erlotinib in Patients With Advanced Non–Small-Cell Lung Cancer

(2012) Suresh S. Ramalingam et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic Mining for Novel FADH2-Dependent Halogenases in Marine Sponge-Associated Microbial Consortia

(2012) Kristina Bayer et al.   MARINE BIOTECHNOLOGY

Changing the Regioselectivity of the Tryptophan 7-Halogenase PrnA by Site-Directed Mutagenesis

(2011) Alexander Lang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalysed halogenation of nucleobase analogues

(2011) Rosario Médici et al.   BIOTECHNOLOGY LETTERS

Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini

(2011) Jia Zeng et al.   BIOTECHNOLOGY LETTERS

Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors

(2011) Zhijian Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Fungal Flavin-Dependent Halogenase for Natural Product Biosynthesis

(2010) Jia Zeng et al.   CHEMBIOCHEM

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs

(2010) Hui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloramphenicol Biosynthesis: The Structure of CmlS, a Flavin-Dependent Halogenase Showing a Covalent Flavin–Aspartate Bond

(2010) Kateryna Podzelinska et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

(2010) Monica Mantri et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Characterization of Tiacumicin B Biosynthetic Gene Cluster Affording Diversified Tiacumicin Analogues and Revealing a Tailoring Dihalogenase

(2010) Yi Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nonbonding interactions of organic halogens in biological systems: implications for drug discovery and biomolecular design

(2010) Yunxiang Lu et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1

(2010) C. S. Neumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational switch triggered by  -ketoglutarate in a halogenase of curacin A biosynthesis

(2010) D. Khare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

(2010) L. C. Foulston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Applications of Palladium-Catalyzed Coupling Reactions in the Pharmaceutical, Agrochemical, and Fine Chemical Industries

(2009) Christian Torborg et al.   ADVANCED SYNTHESIS & CATALYSIS

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Biohalogenation: Nature’s Way to Synthesize Halogenated Metabolites†

(2009) Claudia Wagner et al.   JOURNAL OF NATURAL PRODUCTS

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3

(2009) Cintyu Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic considerations of halogenating enzymes

(2009) Alison Butler et al.   NATURE

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Perspective on Enzymatic Halogenation

(2008) Leah C. Blasiak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Use of fluorinated functionality in enzyme inhibitor development: Mechanistic and analytical advantages

(2008) David B. Berkowitz et al.   JOURNAL OF FLUORINE CHEMISTRY

Structure and Action of the Myxobacterial Chondrochloren Halogenase CndH: A New Variant of FAD-dependent Halogenases

(2008) Stefan Buedenbender et al.   JOURNAL OF MOLECULAR BIOLOGY

Room-Temperature Kumada Cross-Coupling of Unactivated Aryl Chlorides Catalyzed byN-Heterocylic Carbene-Based Nickel(II) Complexes

(2008) Zhenxing Xi et al.   JOURNAL OF ORGANIC CHEMISTRY

Tandem Action of the O2- and FADH2-Dependent Halogenases KtzQ and KtzR Produce 6,7-Dichlorotryptophan for Kutzneride Assembly

(2008) John R. Heemstra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY