Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound

A family of radical halogenases for the engineering of amino-acid-based products

(2019) Monica E. Neugebauer et al.   Nature Chemical Biology

Harnessing biosynthesis and quantitative NMR for late stage functionalization of lead molecules: Application to the M1 positive allosteric modulator (PAM) program

(2018) Michael A. Brodney et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Halogenases: powerful tools for biocatalysis (mechanisms applications and scope)

(2018) Danai S Gkotsi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)–H Bonds

(2017) Ru-Yi Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Frontier Molecular Orbital Contributions to Chlorination versus Hydroxylation Selectivity in the Non-Heme Iron Halogenase SyrB2

(2017) Martin Srnec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed C(sp3)–H Chlorination

(2017) Jun Ozawa et al.   ORGANIC LETTERS

Visible Light-Induced Oxidative Chlorination of Alkyl sp3 C–H Bonds with NaCl/Oxone at Room Temperature

(2017) Mengdi Zhao et al.   ORGANIC LETTERS

Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules

(2016) Matthew L. Hillwig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aliphatic Halogenase Enables Late-Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity

(2016) Qin Zhu et al.   CHEMBIOCHEM

Auxiliary-assisted palladium-catalyzed halogenation of unactivated C(sp3)–H bonds at room temperature

(2016) Xinglin Yang et al.   CHEMICAL COMMUNICATIONS

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

(2016) Andrew J Mitchell et al.   Nature Chemical Biology

Directed evolution of RebH for catalyst-controlled halogenation of indole C–H bonds

(2016) Mary C. Andorfer et al.   Chemical Science

A visible-light-promoted radical reaction system for azidation and halogenation of tertiary aliphatic C–H bonds

(2016) Yaxin Wang et al.   Chemical Science

Synthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activity

(2016) P.-Y. Chung et al.   SpringerPlus

Directed Evolution of RebH for Site-Selective Halogenation of Large Biologically Active Molecules

(2015) James T. Payne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Site-Selective Aliphatic C–H Bromination Using N-Bromoamides and Visible Light

(2014) Valerie A. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new family of iron-dependent halogenases acts on freestanding substrates

(2014) Matthew L Hillwig et al.   Nature Chemical Biology

Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua

(2013) Matthew L. Hillwig et al.   ACS Chemical Biology

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

(2013) Shaun D. Wong et al.   NATURE

Catalytic, Asymmetric Halofunctionalization of Alkenes-A Critical Perspective

(2012) Scott E. Denmark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity

(2012) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

The unique role of halogen substituents in the design of modern agrochemicals

(2009) Peter Jeschke   PEST MANAGEMENT SCIENCE

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereoselective Dichlorination of Allylic Alcohol Derivatives to Access Key Stereochemical Arrays of the Chlorosulfolipids

(2008) Grant M. Shibuya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemo-enzymatic fluorination of unactivated organic compounds

(2008) Andrea Rentmeister et al.   Nature Chemical Biology

Enantioselective synthesis of martinelline chiral core and its diastereomer using asymmetric tandem Michael–aldol reaction

(2008) Yayoi Yoshitomi et al.   TETRAHEDRON