Stapled Peptides—A Useful Improvement for Peptide-Based Drugs

Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides

(2018) Koki Sakagami et al.   MOLECULAR PHARMACEUTICS

An intramolecular tryptophan-condensation approach for peptide stapling

(2018) Eunice Y.-L. Hui et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking

(2018) Aline Dantas de Araujo et al.   ORGANIC LETTERS

Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties

(2017) Marco J. Klein et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Current State of Peptide Drug Discovery: Back to the Future?

(2017) Antoine Henninot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stapled Peptides by Late-Stage C(sp3 )−H Activation

(2016) Anaïs F. M. Noisier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide

(2016) Kuan Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Precise quantification of cellular uptake of cell-penetrating peptides using fluorescence-activated cell sorting and fluorescence correlation spectroscopy

(2016) Rachid Rezgui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ribosome-mediated synthesis of natural product-like peptides via cell-free translation

(2016) Rumit Maini et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Stapled peptides: providing the best of both worlds in drug development

(2016) Xiayang Xie et al.   Future Medicinal Chemistry

Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation

(2016) Yuan Tian et al.   Chemical Science

Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity

(2016) Qingzhou Zhang et al.   Scientific Reports

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Fluorescent Probes from Stable Aromatic Nitrile Oxides

(2015) Luigi Ferdinando Minuti et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Ni(II) Schiff base complexation and structural analysis of fluorinated analogs of the ligand (S)-2-[N-(N′-benzylprolyl)amino]benzophenone (BPB)

(2015) Natalie J. Tatum et al.   JOURNAL OF FLUORINE CHEMISTRY

Towards understanding cell penetration by stapled peptides

(2015) Qian Chu et al.   MedChemComm

New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues

(2015) Lorena Mendive-Tapia et al.   Nature Communications

Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

(2015) Pedro A. Sánchez-Murcia et al.   RSC Advances

Comparative α-Helicity of Cyclic Pentapeptides in Water

(2014) Aline D. de Araujo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding and Reprogramming the Genetic Code of Cells and Animals

(2014) Jason W. Chin   Annual Review of Biochemistry

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Site-Selective C(sp3)–H Functionalization of Di-, Tri-, and Tetrapeptides at the N-Terminus

(2014) Wei Gong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalised staple linkages for modulating the cellular activity of stapled peptides

(2014) Yu Heng Lau et al.   Chemical Science

“On Water”, Phosphine-Free Palladium-Catalyzed Room Temperature CH Arylation of Indoles

(2013) Saidul Islam et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1

(2013) Tara Rao et al.   PLoS One

Azide- and Alkyne-Derivatised α-Amino Acids

(2012) Henrik Johansson et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Nitrile Oxide/Alkyne Cycloadditions - A Credible Platform for Synthesis of Bioinspired Molecules by Metal-Free Molecular Clicking

(2012) Frances Heaney   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

On the binding affinity of macromolecular interactions: daring to ask why proteins interact

(2012) P. L. Kastritis et al.   Journal of the Royal Society Interface

Protein transduction domain delivery of therapeutic macromolecules

(2011) Arjen van den Berg et al.   CURRENT OPINION IN BIOTECHNOLOGY

Rapid model building of α-helices in electron-density maps

(2010) Thomas C. Terwilliger   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

(2010) G. H. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Equilibrium Ring-Closing Metathesis

(2009) Sebastien Monfette et al.   CHEMICAL REVIEWS

Ruthenium-Based Heterocyclic Carbene-Coordinated Olefin Metathesis Catalysts†

(2009) Georgios C. Vougioukalakis et al.   CHEMICAL REVIEWS

A Photoinducible 1,3-Dipolar Cycloaddition Reaction for Rapid, Selective Modification of Tetrazole-Containing Proteins

(2008) Wenjiao Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorescent Labeling of Biomolecules with Organic Probes

(2008) M. Sameiro T. Gonçalves   CHEMICAL REVIEWS

Cu(II)-Catalyzed Direct and Site-Selective Arylation of Indoles Under Mild Conditions

(2008) Robert J. Phipps et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY