Nitrile Oxide/Alkyne Cycloadditions - A Credible Platform for Synthesis of Bioinspired Molecules by Metal-Free Molecular Clicking

Genetically Encoded Copper-Free Click Chemistry

(2011) Tilman Plass et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bio-orthogonal “Double-Click” Chemistry Based on Multifunctional Coatings

(2011) Xiaopei Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reliable and Efficient Procedures for the Conjugation of Biomolecules through Huisgen Azide-Alkyne Cycloadditions

(2011) Enrique Lallana et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strain-Promoted Copper-Free “Click” Chemistry for 18F Radiolabeling of Bombesin

(2011) Lachlan S. Campbell-Verduyn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study

(2011) Christen Besanceney-Webler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strain-Promoted “Click” Chemistry for Terminal Labeling of DNA

(2011) Isaac S. Marks et al.   BIOCONJUGATE CHEMISTRY

Clickable Enzyme-Linked Immunosorbent Assay

(2011) Luiz A. Canalle et al.   BIOMACROMOLECULES

Strain-Promoted Alkyne-Azide Cycloadditions (SPAAC) Reveal New Features of Glycoconjugate Biosynthesis

(2011) Ngalle Eric Mbua et al.   CHEMBIOCHEM

Directing the pathway of orthogonal ‘click’ reactions by modulating copper-catalytic activity

(2011) Zhongfan Jia et al.   CHEMICAL COMMUNICATIONS

Synthesis of oligonucleotides possessing versatile probes for PET labelling and their rapid ligand-free click reaction

(2011) Takao Shiraishi et al.   CHEMICAL COMMUNICATIONS

Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction

(2011) Montserrat Shelbourne et al.   CHEMICAL COMMUNICATIONS

Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

(2011) Anup M. Jawalekar et al.   CHEMICAL COMMUNICATIONS

An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics

(2011) Thazha P. Prakash   CHEMISTRY & BIODIVERSITY

Cytocompatible Poly(ethylene glycol)-co-polycarbonate Hydrogels Cross-Linked by Copper-Free, Strain-Promoted Click Chemistry

(2011) Jianwen Xu et al.   Chemistry-An Asian Journal

Efficient Synthesis of DNA Conjugates by Strain-Promoted Azide-Cyclooctyne Cycloaddition in the Solid Phase

(2011) Ishwar Singh et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Facile One-pot Synthesis of N α-Urethane Protected 3-Amino Alkyl Isoxazole-5-Carboxylic Acids and their Utility for the Preparation of Isoxazole-Linked Peptidomimetics

(2011) G. Chennakrishnareddy et al.   International Journal of Peptide Research and Therapeutics

Versatile Site-Specific Conjugation of Small Molecules to siRNA Using Click Chemistry

(2011) Takeshi Yamada et al.   JOURNAL OF ORGANIC CHEMISTRY

Three-Fold Metal-Free Efficient (“Click”) Reactions onto a Multifunctional Poly(2-oxazoline) Designer Scaffold

(2011) Kristian Kempe et al.   MACROMOLECULES

N-Heterocyclic carbene-catalyzed 1,3-dipolar cycloaddition reactions: a facile synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles

(2011) Shravankumar Kankala et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry

(2011) Colin Freeman et al.   TETRAHEDRON

Oligonucleotide Carbohydrate-Centered Galactosyl Cluster Conjugates Synthesized by Click and Phosphoramidite Chemistries

(2010) Gwladys Pourceau et al.   BIOCONJUGATE CHEMISTRY

Surface Functionalization Using Catalyst-Free Azide−Alkyne Cycloaddition

(2010) Alexander Kuzmin et al.   BIOCONJUGATE CHEMISTRY

Copper-Free Click Chemistry for Highly Luminescent Quantum Dot Conjugates: Application toin VivoMetabolic Imaging

(2010) Aude Bernardin et al.   BIOCONJUGATE CHEMISTRY

Catalyst- and Solvent-Free “Click” Chemistry: A Facile Approach to Obtain Cross-Linked Biopolymers from Soybean Oil

(2010) Jian Hong et al.   BIOMACROMOLECULES

A DOTA–peptide conjugate by copper-free click chemistry

(2010) Molly E. Martin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Click Chemistry for Rapid Labeling and Ligation of RNA

(2010) Eduardo Paredes et al.   CHEMBIOCHEM

Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs)

(2010) Michael E. Østergaard et al.   CHEMICAL COMMUNICATIONS

Conformational and supramolecular properties of main chain and cyclic click oligotriazoles and polytriazoles

(2010) Hak-Fun Chow et al.   CHEMICAL COMMUNICATIONS

Facile access to internally functionalized dendrimers through efficient and orthogonal click reactions

(2010) Taegon Kang et al.   CHEMICAL COMMUNICATIONS

Copper nitride nanoparticles supported on a superparamagnetic mesoporous microsphere for toxic-free click chemistry

(2010) Byoung Se Lee et al.   CHEMICAL COMMUNICATIONS

Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

(2010) Ishwar Singh et al.   CHEMICAL COMMUNICATIONS

Electrochemical applications. How click chemistry brought biomimetic models to the next level: electrocatalysis under controlled rate of electron transfer

(2010) Richard A. Decréau et al.   CHEMICAL SOCIETY REVIEWS

In situ click chemistry: probing the binding landscapes of biological molecules

(2010) Sreeman K. Mamidyala et al.   CHEMICAL SOCIETY REVIEWS

Click chemistry generates privileged CH hydrogen-bonding triazoles: the latest addition to anion supramolecular chemistry

(2010) Yuran Hua et al.   CHEMICAL SOCIETY REVIEWS

Recent developments in oligonucleotide conjugation

(2010) Yashveer Singh et al.   CHEMICAL SOCIETY REVIEWS

Click polymerization

(2010) Anjun Qin et al.   CHEMICAL SOCIETY REVIEWS

Click chemistry with DNA

(2010) Afaf H. El-Sagheer et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of a Kinetically Stabilized Homoditopic NitrileN-Oxide Directed toward Catalyst-free Click Polymerization

(2010) Young-Gi Lee et al.   CHEMISTRY LETTERS

Convergent Assembly and Surface Modification of Multifunctional Dendrimers by Three Consecutive Click Reactions

(2010) Petr A. Ledin et al.   CHEMISTRY-A EUROPEAN JOURNAL

High-Density DNA Functionalization by a Combination of Cu-Catalyzed and Cu-Free Click Chemistry

(2010) Katrin Gutsmiedl et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Template-Mediated Click-Click Reaction: PNA-DNA, PNA-PNA (or Peptide) Ligation, and Single Nucleotide Discrimination

(2010) Xiaohua Peng et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cross-Linked DNA Generated by “Bis-click” Reactions with Bis-functional Azides: Site Independent Ligation of Oligonucleotides via Nucleobase Alkynyl Chains

(2010) Suresh S. Pujari et al.   JOURNAL OF ORGANIC CHEMISTRY

Strain-Promoted Alkyne Azide Cycloaddition for the Functionalization of Poly(amide)-Based Dendrons and Dendrimers

(2010) Cátia Ornelas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High Density Orthogonal Surface Immobilization via Photoactivated Copper-Free Click Chemistry

(2010) Sara V. Orski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Free Sequential [3 + 2]-Dipolar Cycloadditions using Cyclooctynes and 1,3-Dipoles of Different Reactivity

(2010) Brian C. Sanders et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Comparison of Triazole-forming Bioconjugation Techniques for Constructing Comb-Shaped Peptide-Polymer Bioconjugates

(2010) Luiz A. Canalle et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Synthesis of Main-Chain-Type Polyrotaxanes by New Click Polymerization Using Homoditopic NitrileN-Oxides via Rotaxanation−Polymerization Protocol

(2010) Young-Gi Lee et al.   MACROMOLECULES

Enhanced rate of intramolecular nitrile oxide cycloaddition and rapid synthesis of isoxazoles and isoxazolines

(2010) Brindaban Roy et al.   MONATSHEFTE FUR CHEMIE

Non-Nucleoside Building Blocks for Copper-Assisted and Copper-Free Click Chemistry for the Efficient Synthesis of RNA Conjugates

(2010) K. N. Jayaprakash et al.   ORGANIC LETTERS

Synthesis of Oligoribonucleic Acid Conjugates Using a Cyclooctyne Phosphoramidite

(2010) Pieter van Delft et al.   ORGANIC LETTERS

C−C Bond-Forming Click Synthesis of Rotaxanes Exploiting NitrileN-Oxide

(2010) Tohru Matsumura et al.   ORGANIC LETTERS

Orthogonal modification of polymer chain-ends via sequential nitrile oxide–alkyne and azide–alkyne Huisgen cycloadditions

(2010) Ishwar Singh et al.   Polymer Chemistry

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modification of nucleic acids using [3 + 2]-dipolar cycloaddition of azides and alkynes

(2010) A. V. Ustinov et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Application of copper(I)-catalysed azide/alkyne cycloaddition (CuAAC) ‘click chemistry’ in carbohydrate drug and neoglycopolymer synthesis

(2010) Valquiria Aragão-Leoneti et al.   TETRAHEDRON

Solid-Phase Synthesis of Oligonucleotide Conjugates Useful for Delivery and Targeting of Potential Nucleic Acid Therapeutics

(2009) Harri Lönnberg   BIOCONJUGATE CHEMISTRY

C5-Modified nucleosides exhibiting anticancer activity

(2009) Yoon-Suk Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

(2009) Ishwar Singh et al.   CHEMICAL COMMUNICATIONS

Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes

(2009) Craig S. McKay et al.   CHEMICAL COMMUNICATIONS

Risks of Copper and Iron Toxicity during Aging in Humans

(2009) George J. Brewer   CHEMICAL RESEARCH IN TOXICOLOGY

Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials

(2009) Rhiannon K. Iha et al.   CHEMICAL REVIEWS

Marrying click chemistry with polymerization: expanding the scope of polymeric materials

(2009) Patricia L. Golas et al.   CHEMICAL SOCIETY REVIEWS

Diels-Alder “Click” Chemistry in Designing Dendritic Macromolecules

(2009) Grégory Franc et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Mannose and Galactose Oligonucleotide Conjugates by Bi-click chemistry

(2009) Gwladys Pourceau et al.   JOURNAL OF ORGANIC CHEMISTRY

Surpassing the Use of Copper in the Click Functionalization of Polymeric Nanostructures: A Strain-Promoted Approach

(2009) Enrique Lallana et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Labeling of Living Cells by a Photo-Triggered Click Reaction

(2009) Andrei A. Poloukhtine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Characterization of Isomeric Vinyl-1,2,3-triazole Materials by Azide−Alkyne Click Chemistry

(2009) Hunaid Nulwala et al.   MACROMOLECULES

Metal-Free “Click” Chemistry: Efficient Polymer Modification via 1,3-Dipolar Cycloaddition of Nitrile Oxides and Alkynes

(2009) Ishwar Singh et al.   MACROMOLECULES

New Click Chemistry: Polymerization Based on 1,3-Dipolar Cycloaddition of a Homo Ditopic NitrileN-Oxide and Transformation of the Resulting Polymers into Reactive Polymers

(2009) Young-Gi Lee et al.   MACROMOLECULES

Functional end groups for polymers prepared using ring-opening metathesis polymerization

(2009) Stefan Hilf et al.   Nature Chemistry

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

Hypervalent iodine(iii)-mediated oxidation of aldoximes to N-acetoxy or N-hydroxy amides

(2009) Harisadhan Ghosh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Metal free, “click and click–click” conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase

(2009) Ishwar Singh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide–alkyne1,3-dipolar cycloaddition

(2009) Virginie Algay et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Free “Click” Modification of DNA via Nitrile Oxide−Norbornene 1,3-Dipolar Cycloaddition

(2009) Katrin Gutsmiedl et al.   ORGANIC LETTERS

Dimerisation of nitrile oxides: a quantum-chemical study

(2009) Tibor Pasinszki et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A Procedure for Fast and Regioselective Copper-Free Click Chemistry at Room Temperature with p-Toluenesulfonyl Alkyne

(2009) Sébastien Gouin et al.   SYNLETT

‘Click’ Chemistry on Sugar-Derived Alkynes: A Tandem ‘Click-Click’ Approach to Bistriazoles

(2009) Krishna Kaliappan et al.   SYNLETT

Synthesis of Isoxazole Conjugates of 1,4-Benzodioxane Moiety via Intermolecular 1,3-Dipolar Cycloaddition

(2009) Vipraja V. Vaidya et al.   SYNTHETIC COMMUNICATIONS

Utilization of Intrachain 4′-C-Azidomethylthymidine for Preparation of Oligodeoxyribonucleotide Conjugates by Click Chemistry in Solution and on a Solid Support

(2008) Anu Kiviniemi et al.   BIOCONJUGATE CHEMISTRY

siRNA Conjugate Delivery Systems

(2008) Ji Hoon Jeong et al.   BIOCONJUGATE CHEMISTRY

Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives

(2008) Frank Wuest et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of isoxazole conjugates of sugars via 1,3-dipolar cycloaddition

(2008) Vipraja V Vaidya et al.   CANADIAN JOURNAL OF CHEMISTRY

A new bio-active surface for protein immobilisation via copper-free ‘click’ between azido SAM and alkynyl Fischer carbene complex

(2008) Sudeshna Sawoo et al.   CHEMICAL COMMUNICATIONS

New Click Chemistry: Click Polymerization via 1,3-Dipolar Addition of Homo-ditopic Aromatic Nitrile Oxides Formed In Situ

(2008) Yasuhito Koyama et al.   CHEMISTRY LETTERS

Synthesis of Stable Aminoacyl-tRNA Analogues Containing Triazole as a Bioisoster of Esters

(2008) Maryline Chemama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemical Strategies for Oligonucleotide-Conjugates Synthesis

(2008) E. Defrancq et al.   CURRENT ORGANIC CHEMISTRY

Solid-Phase Synthesis of Heterocyclic Nucleoside Analogues: Substituted Uracils Tethered to Isoxazoles, Isoxazolines, and Triazoles from a Selenopolystyrene Resin

(2008) Jian Cao et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Lipid-Conjugated Oligonucleotides via “Click Chemistry” Efficiently Inhibit Hepatitis C Virus Translation

(2008) Guilhem Godeau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry

(2008) Julian A. Codelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Azide−Alkyne Cycloaddition: Scope and Mechanism

(2008) Brant C. Boren et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymer “Clicking” by CuAAC Reactions

(2008) Morten Meldal   MACROMOLECULAR RAPID COMMUNICATIONS

A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry

(2008) Ellen M. Sletten et al.   ORGANIC LETTERS

Preparation of ribavirin analogues by copper- and ruthenium-catalyzed azide-alkyne 1,3-dipolar cycloaddition

(2008) Ugo Pradere et al.   TETRAHEDRON

Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne−Azide “Click” Reaction

(2007) Frank Seela et al.   BIOCONJUGATE CHEMISTRY

Computational note on ab initio studies of 1,3-dipolar cycloaddition reactions between 7–10 membered simple cycloalkynes and nitriloxide

(2007) Avat (Arman) Taherpour et al.   JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM

Microwave-assisted synthesis of a triazole-linked 3′–5′ dithymidine using click chemistry

(2007) Romain Lucas et al.   TETRAHEDRON LETTERS