TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

(2019) Kent Miner et al.   Frontiers in Pharmacology

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

(2019) Karl Kunzelmann et al.   Frontiers in Pharmacology

Focus on TRP channels in cystic fibrosis

(2019) Chloé Grebert et al.   CELL CALCIUM

A cellular census of human lungs identifies novel cell states in health and in asthma

(2019) Felipe A. Vieira Braga et al.   NATURE MEDICINE

Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38–Mitogen-activated Protein Kinase–Dependent Apoptosis

(2018) Ayed M. Allawzi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TRPV4 heats up ANO1-dependent exocrine gland fluid secretion

(2018) Sandra Derouiche et al.   FASEB JOURNAL

Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling

(2018) Yan Song et al.   Cell Death & Disease

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

(2018) Lindsey W. Plasschaert et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

TMEM16A is indispensable for basal mucus secretion in airways and intestine

(2018) Roberta Benedetto et al.   FASEB JOURNAL

Structure, Gating, and Regulation of the CFTR Anion Channel

(2018) László Csanády et al.   PHYSIOLOGICAL REVIEWS

TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

(2017) Yeranddy A. Alpizar et al.   Nature Communications

Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours

(2016) Shenbin Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cystic fibrosis

(2016) J Stuart Elborn   LANCET

Cellular functions of TMEM16/anoctamin

(2016) Uhtaek Oh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release

(2016) Giulia Gorrieri et al.   Scientific Reports

Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2

(2016) Yohan Seo et al.   PLoS One

Intermolecular Interactions in the TMEM16A Dimer Controlling Channel Activity

(2016) Paolo Scudieri et al.   Scientific Reports

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Anoctamin 1 Calcium-Activated Chloride Channel Downregulates Estrogen Production in Mouse Ovarian Granulosa Cells

(2014) Meiyan Sun et al.   ENDOCRINOLOGY

Functional role of the Ca2+-activated Cl− channel DOG1/TMEM16A in gastrointestinal stromal tumor cells

(2014) Erik Berglund et al.   EXPERIMENTAL CELL RESEARCH

Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1

(2014) Yasunori Takayama et al.   FASEB JOURNAL

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

The secret life of CFTR as a calcium-activated chloride channel

(2013) Arnaud Billet et al.   JOURNAL OF PHYSIOLOGY-LONDON

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

(2012) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Determinants of TRPV4 Activity following Selective Activation by Small Molecule Agonist GSK1016790A

(2011) Min Jin et al.   PLoS One

Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

(2010) Wan Namkung et al.   FASEB JOURNAL

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

(2010) Wan Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures

(2010) Wan Namkung et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2

(2008) R. N. Willette et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells

(2008) I. M. Lorenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE