Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes

(2018) Jens Markus Borghardt et al.   Canadian Respiratory Journal

Niclosamide: Beyond an antihelminthic drug

(2018) Wei Chen et al.   CELLULAR SIGNALLING

Current approaches to the discovery of novel inhaled medicines

(2018) Peter Strong et al.   DRUG DISCOVERY TODAY

Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor–transmembrane protein 16A–voltage-dependent Ca 2+ channel axis and contribute to bronchial hyperresponsiveness in asthma

(2018) Pei Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction

(2018) Eleanor M. Dunican et al.   JOURNAL OF CLINICAL INVESTIGATION

Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling

(2017) Rachid Berair et al.   EUROPEAN RESPIRATORY JOURNAL

Differential effects of anoctamins on intracellular calcium signals

(2017) Inês Cabrita et al.   FASEB JOURNAL

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid

(2017) Rainer Schreiber et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

(2017) Hui Wang et al.   Molecular Cancer

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

(2017) Cristina Paulino et al.   NATURE

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

(2017) Shangyu Dang et al.   NATURE

Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation

(2017) Raphael Rapetti-Mauss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

(2017) Cristina Paulino et al.   eLife

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Epithelial Chloride Transport by CFTR Requires TMEM16A

(2017) Roberta Benedetto et al.   Scientific Reports

Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries

(2016) Qian Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours

(2016) Shenbin Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interleukin-13 stimulates MUC5AC expression via a STAT6-TMEM16A-ERK1/2 pathway in human airway epithelial cells

(2016) Yanling Qin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Animal models of COPD: What do they tell us?

(2016) Bernadette Jones et al.   RESPIROLOGY

Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo

(2016) D. C. Adams et al.   Science Translational Medicine

Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release

(2016) Giulia Gorrieri et al.   Scientific Reports

A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers

(2016) Kamal Ahmed et al.   Cancers

Defining an olfactory receptor function in airway smooth muscle cells

(2016) William H. Aisenberg et al.   Scientific Reports

Future Research Directions in Asthma. An NHLBI Working Group Report

(2015) Bruce D. Levy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antagonists of the TMEM16A Calcium-activated Chloride Channel Modulate Airway Smooth Muscle Tone and Intracellular Calcium

(2015) Jennifer Danielsson et al.   ANESTHESIOLOGY

Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure

(2015) Robert A. Mook et al.   BIOORGANIC & MEDICINAL CHEMISTRY

TMEM16A mediates the hypersecretion of mucus induced by Interleukin-13

(2015) Jiachen Lin et al.   EXPERIMENTAL CELL RESEARCH

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

(2015) W. Senkowski et al.   MOLECULAR CANCER THERAPEUTICS

Role of Anoctamin-1 and Bestrophin-1 in Spinal Nerve Ligation-Induced Neuropathic Pain in Rats

(2015) Jorge Baruch Pineda-Farias et al.   Molecular Pain

Secretory diarrhoea: mechanisms and emerging therapies

(2015) Jay R. Thiagarajah et al.   Nature Reviews Gastroenterology & Hepatology

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels

(2015) Christian J. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons

(2015) Yasunori Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients

(2015) Yu Zhang et al.   Allergy Asthma & Immunology Research

ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer

(2015) Anke Bill et al.   Oncotarget

Asthma

(2015) Stephen T. Holgate et al.   Nature Reviews Disease Primers

Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin

(2015) Emanuela Caci et al.   PLoS One

Chloride channel blockade relaxes airway smooth muscle and potentiates relaxation by β-agonists

(2014) Jennifer Danielsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Nitazoxanide: A first-in-class broad-spectrum antiviral agent

(2014) Jean-François Rossignol   ANTIVIRAL RESEARCH

Multi-targeted therapy of cancer by niclosamide: A new application for an old drug

(2014) Yonghe Li et al.   CANCER LETTERS

Pharmacological characterization of TMEM16A currents

(2014) Eamonn Bradley et al.   Channels

Animal models of chronic obstructive pulmonary disease

(2014) Michael Fricker et al.   Expert Opinion on Drug Discovery

The TMEM16A chloride channel as an alternative therapeutic target in cystic fibrosis

(2014) Elvira Sondo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure

(2014) Christoph Heinze et al.   JOURNAL OF CLINICAL INVESTIGATION

Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity

(2014) Byeongjun Lee et al.   Molecular Pain

Characterization of the effects of Cl− channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl− channels

(2014) Yani Liu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation and Inhibition of TMEM16A Calcium-Activated Chloride Channels

(2014) Yu-Li Ni et al.   PLoS One

Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

(2014) Stephen Patterson et al.   TRENDS IN PARASITOLOGY

Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action

(2014) Michael J. Stocks et al.   ACS Medicinal Chemistry Letters

Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle

(2013) George Gallos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Bitter Taste Receptor Function in Asthmatic and Nonasthmatic Human Airway Smooth Muscle Cells

(2013) Kathryn S. Robinett et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma

(2013) Lorcan P. McGarvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells

(2013) Bjoern Buchholz et al.   KIDNEY INTERNATIONAL

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling

(2013) Adrian Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Cl- Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor

(2013) X. Jin et al.   Science Signaling

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

(2012) Abigail S. Forrest et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Transmembrane Protein 16A Ca2+-activated Cl−Channel in Airway Smooth Muscle Contributes to Airway Hyperresponsiveness

(2012) Cheng-Hai Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of Ca2+-activated Cl− channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma

(2012) Wen Liu et al.   CANCER LETTERS

TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

(2012) U. Duvvuri et al.   CANCER RESEARCH

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

(2012) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

DOG1: a novel marker of salivary acinar and intercalated duct differentiation

(2012) Jacinthe Chênevert et al.   MODERN PATHOLOGY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

(2012) Hawon Cho et al.   NATURE NEUROSCIENCE

Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network

(2012) P. Perez-Cornejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations

(2011) T. Osada et al.   CANCER RESEARCH

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Physical Forces and Airway Remodeling in Asthma

(2011) Daniel J. Tschumperlin   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Bronchoconstriction on Airway Remodeling in Asthma

(2011) Christopher L. Grainge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption

(2011) Jiraporn Ousingsawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D

(2011) Thomas Trian et al.   PLoS One

Interactions between β-Catenin and the HSlo Potassium Channel Regulates HSlo Surface Expression

(2011) Shumin Bian et al.   PLoS One

Expression profile and protein translation of TMEM16A in murine smooth muscle

(2010) Alison J. Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

(2010) Wan Namkung et al.   FASEB JOURNAL

Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma

(2010) Muhannad Hassan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tmem16AEncodes the Ca2+-activated Cl−Channel in Mouse Submandibular Salivary Gland Acinar Cells

(2010) Victor G. Romanenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

(2009) Loretta Ferrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steroid-Resistant Neutrophilic Inflammation in a Mouse Model of an Acute Exacerbation of Asthma

(2008) Kazuhiro Ito et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE