TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase

Interaction with the Bardet-Biedl Gene Product TRIM32/BBS11 Modifies the Half-life and Localization of Glis2/NPHP7

(2014) Haribaskar Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactome Analysis of the Influenza A Virus Transcription/Replication Machinery Identifies Protein Phosphatase 6 as a Cellular Factor Required for Efficient Virus Replication

(2014) A. York et al.   JOURNAL OF VIROLOGY

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

Trim65: A cofactor for regulation of the microRNA pathway

(2014) Shitao Li et al.   RNA Biology

Generation and characterization of influenza A viruses with altered polymerase fidelity

(2014) Peter P. H. Cheung et al.   Nature Communications

The ubiquitin conjugating enzyme UBE2L3 regulates TNFα-induced linear ubiquitination

(2013) Bishi Fu et al.   CELL RESEARCH

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

Tripartite Motif Ligases Catalyze Polyubiquitin Chain Formation through a Cooperative Allosteric Mechanism

(2013) Frederick C. Streich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation

(2013) T. Ichimura et al.   JOURNAL OF CELL SCIENCE

TRIMmunity: The Roles of the TRIM E3-Ubiquitin Ligase Family in Innate Antiviral Immunity

(2013) Ricardo Rajsbaum et al.   JOURNAL OF MOLECULAR BIOLOGY

In Vivo Bioluminescent Imaging of Influenza A Virus Infection and Characterization of Novel Cross-Protective Monoclonal Antibodies

(2013) N. S. Heaton et al.   JOURNAL OF VIROLOGY

A patient with limb girdle muscular dystrophy carries a TRIM32 deletion, detected by a novel CGH array, in compound heterozygosis with a nonsense mutation

(2013) M. Neri et al.   NEUROMUSCULAR DISORDERS

Regulatory feedback loop between TP73 and TRIM32

(2013) L Gonzalez-Cano et al.   Cell Death & Disease

TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation

(2013) A-L Hillje et al.   Cell Death & Disease

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

(2012) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

(2012) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

TRIM Protein-Mediated Regulation of Inflammatory and Innate Immune Signaling and Its Association with Antiretroviral Activity

(2012) P. D. Uchil et al.   JOURNAL OF VIROLOGY

TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and Is Necessary for Normal Adult Muscle Regeneration

(2012) Sarah Nicklas et al.   PLoS One

NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses

(2012) Lingyan Wang et al.   PLoS One

Functional interactions between ubiquitin E2 enzymes and TRIM proteins

(2011) Luisa M. Napolitano et al.   BIOCHEMICAL JOURNAL

The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype

(2011) E. Kudryashova et al.   HUMAN MOLECULAR GENETICS

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

TRIM32 Protein Sensitizes Cells to Tumor Necrosis Factor (TNFα)-induced Apoptosis via Its RING Domain-dependent E3 Ligase Activity against X-linked Inhibitor of Apoptosis (XIAP)

(2011) Yeung Sook Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription

(2011) T. Sato et al.   JOURNAL OF CELL SCIENCE

Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences

(2011) P. Reuther et al.   JOURNAL OF VIROLOGY

Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors

(2011) B. G. Bradel-Tretheway et al.   JOURNAL OF VIROLOGY

Nuclear Factor Kappa B Signaling Initiates Early Differentiation of Neural Stem Cells

(2011) Yonggang Zhang et al.   STEM CELLS

Illumination of Parainfluenza Virus Infection and Transmission in Living Animals Reveals a Tissue-Specific Dichotomy

(2011) Crystal W. Burke et al.   PLoS Pathogens

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

(2010) A. Breitkreutz et al.   SCIENCE

nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans

(2009) Christopher M. Hammell et al.   CELL

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

(2009) Jens C. Schwamborn et al.   CELL

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

(2009) Elena Kudryashova et al.   HUMAN MOLECULAR GENETICS

TRIM32 is an E3 ubiquitin ligase for dysbindin

(2009) Matthew Locke et al.   HUMAN MOLECULAR GENETICS

PKC Phosphorylation of TRAF2 Mediates IKKα/β Recruitment and K63-Linked Polyubiquitination

(2009) Shitao Li et al.   MOLECULAR CELL

Tripartite Motif Protein 32 Facilitates Cell Growth and Migration via Degradation of Abl-Interactor 2

(2008) S. Kano et al.   CANCER RESEARCH

Limb–girdle muscular dystrophies

(2008) Michela Guglieri et al.   CURRENT OPINION IN NEUROLOGY

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

(2008) Pradeep D. Uchil et al.   PLoS Pathogens

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H

(2007) Valentina Saccone et al.   HUMAN MUTATION