Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival

(2015) J M Calandria et al.   CELL DEATH AND DIFFERENTIATION

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Therapeutic implications of the prostaglandin pathway in Alzheimer's disease

(2014) Eiron Cudaback et al.   BIOCHEMICAL PHARMACOLOGY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Phosphorylation of 5-Lipoxygenase at Ser523 by Protein Kinase A Determines Whether Pioglitazone and Atorvastatin Induce Proinflammatory Leukotriene B4 or Anti-Inflammatory 15-Epi-Lipoxin A4 Production

(2014) Y. Ye et al.   JOURNAL OF IMMUNOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma

(2013) Zhen-Zhong Xu et al.   ANNALS OF NEUROLOGY

Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date

(2013) Laurence Balas et al.   BIOCHIMIE

Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury

(2013) Cheng-Liang Luo et al.   BRAIN RESEARCH

Resolvin D1, an Endogenous Lipid Mediator for Inactivation of Inflammation-Related Signaling Pathways in Microglial Cells, Prevents Lipopolysaccharide-Induced Inflammatory Responses

(2013) Min-Xuan Xu et al.   CNS Neuroscience & Therapeutics

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators

(2013) Yongsheng Li et al.   IMMUNITY

Protectin DX, a Double Lipoxygenase Product of DHA, Inhibits Both ROS Production in Human Neutrophils and Cyclooxygenase Activities

(2013) Miao Liu et al.   LIPIDS

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Ataxin-1 Poly(Q)-induced Proteotoxic Stress and Apoptosis Are Attenuated in Neural Cells by Docosahexaenoic Acid-derived Neuroprotectin D1

(2012) Jorgelina M. Calandria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway

(2012) Zenglin Liao et al.   RESPIRATORY RESEARCH

Non-Steroidal Anti-Inflammatory Drugs and Cognitive Function: Are Prostaglandins at the Heart of Cognitive Impairment in Dementia and Delirium ?

(2011) Colm Cunningham et al.   Journal of Neuroimmune Pharmacology

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways

(2010) P Prieto et al.   CELL DEATH AND DIFFERENTIATION

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

The Vi Capsular Polysaccharide Prevents Complement Receptor 3-Mediated Clearance ofSalmonella entericaSerotype Typhi

(2010) R. Paul Wilson et al.   INFECTION AND IMMUNITY

Neuroprotectin D1 Induces Dephosphorylation of Bcl-xLin a PP2A-dependent Manner during Oxidative Stress and Promotes Retinal Pigment Epithelial Cell Survival

(2010) Rajee Antony et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

(2010) Janesh Pillay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NPD1 Induction of Retinal Pigment Epithelial Cell Survival Involves PI3K/Akt Phosphorylation Signaling

(2010) Natalie A. Halapin et al.   NEUROCHEMICAL RESEARCH

Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

(2010) Giuseppe Astarita et al.   PLoS One

β-Amyloid 1-42 Oligomers Impair Function of Human Embryonic Stem Cell-Derived Forebrain Cholinergic Neurons

(2010) Linn Wicklund et al.   PLoS One

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD40/CD40L interaction induces Aβ production and increases γ-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling

(2009) Claude-Henry Volmar et al.   EXPERIMENTAL CELL RESEARCH

Synthesis of Lipoxin A4 by 5-Lipoxygenase Mediates PPAR -Dependent, Neuroprotective Effects of Rosiglitazone in Experimental Stroke

(2009) M. Sobrado et al.   JOURNAL OF NEUROSCIENCE

Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease

(2008) Milos D. Ikonomovic et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Mechanisms Mediating Reduced Responsiveness of Neonatal Neutrophils to Lipoxin A4

(2008) Barry Weinberger et al.   PEDIATRIC RESEARCH

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

(2007) Omidreza Firuzi et al.   FASEB JOURNAL