Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus-Merzbacher Disease

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model

(2014) Thomas Prukop et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination

(2013) Su Wang et al.   Cell Stem Cell

Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain

(2013) Adam D Bachstetter et al.   Journal of Neuroinflammation

Gait Abnormalities and Progressive Myelin Degeneration in a New Murine Model of Pelizaeus-Merzbacher Disease with Tandem Genomic Duplication

(2013) K. Clark et al.   JOURNAL OF NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF

(2013) Cecilia Laterza et al.   Nature Communications

Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord

(2012) Melania Cusimano et al.   BRAIN

The innate immune system in demyelinating disease

(2012) Lior Mayo et al.   IMMUNOLOGICAL REVIEWS

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

(2012) Gesine Saher et al.   NATURE MEDICINE

Neuroinflammation by Cytotoxic T-Lymphocytes Impairs Retrograde Axonal Transport in an Oligodendrocyte Mutant Mouse

(2012) Chi Wang Ip et al.   PLoS One

Glial Progenitor Cell-Based Treatment and Modeling of Neurological Disease

(2012) S. A. Goldman et al.   SCIENCE

Human Neural Stem Cells Induce Functional Myelination in Mice with Severe Dysmyelination

(2012) N. Uchida et al.   Science Translational Medicine

Neural Stem Cell Engraftment and Myelination in the Human Brain

(2012) N. Gupta et al.   Science Translational Medicine

Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord

(2011) Delphine Buchet et al.   BRAIN

Macrophages Counteract Demyelination in a Mouse Model of Globoid Cell Leukodystrophy

(2011) Y. Kondo et al.   JOURNAL OF NEUROSCIENCE

CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells

(2011) Fraser J Sim et al.   NATURE BIOTECHNOLOGY

Increased Plp1 Gene Expression Leads to Massive Microglial Cell Activation and Inflammation Throughout the Brain

(2010) Carrie L Tatar et al.   ASN Neuro

Neuronal loss in Pelizaeus–Merzbacher disease differs in various mutations of the proteolipid protein 1

(2009) Anders A. F. Sima et al.   ACTA NEUROPATHOLOGICA

Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates

(2009) Stefano Pluchino et al.   ANNALS OF NEUROLOGY

Rescue of Congenital Hypomyelination by Progenitor Cell Transplantation

(2008) Bruce D. Trapp   Cell Stem Cell

Neonatal Chimerization with Human Glial Progenitor Cells Can Both Remyelinate and Rescue the Otherwise Lethally Hypomyelinated Shiverer Mouse

(2008) Martha S. Windrem et al.   Cell Stem Cell