Multiple sclerosis: experimental models and reality

Cause and prevention of demyelination in a model multiple sclerosis lesion

(2016) Roshni A. Desai et al.   ANNALS OF NEUROLOGY

Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

(2016) Bjørn A. Nexø et al.   BMC Neurology

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

(2016) Lukas Haider et al.   BRAIN

Beginning of the end of two-stage theory purporting that inflammation then degeneration explains pathogenesis of progressive multiple sclerosis

(2016) Lawrence Steinman et al.   CURRENT OPINION IN NEUROLOGY

Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice

(2016) Laura A. N. Peferoen et al.   IMMUNOLOGY

Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes

(2016) Maria Sepúlveda et al.   JOURNAL OF NEUROLOGY

Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the Forebrain

(2016) M. Scheld et al.   JOURNAL OF NEUROSCIENCE

Parenteral Treatment of Multiple Sclerosis: The Advent of Monoclonal Antibodies

(2016) Barry Singer   SEMINARS IN NEUROLOGY

Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention—An Update

(2016) Kassandra Munger et al.   SEMINARS IN NEUROLOGY

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

(2016) Abbe H. Crawford et al.   Cell Reports

Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS

(2015) Bleranda Zeka et al.   ACTA NEUROPATHOLOGICA

Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants

(2015) Kevin Blauth et al.   ACTA NEUROPATHOLOGICA

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

(2015) Josa M. Frischer et al.   ANNALS OF NEUROLOGY

Immune profile of an atypical EAE model in marmoset monkeys immunized with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund’s adjuvant

(2015) S. Anwar Jagessar et al.   Journal of Neuroinflammation

The effect of B-cell depletion in the Theiler's model of multiple sclerosis

(2015) Francesca Gilli et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?

(2015) Romana Höftberger et al.   Acta Neuropathologica Communications

Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody

(2015) Kazuhiro Kurosawa et al.   Acta Neuropathologica Communications

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

(2014) Cornelia Schuh et al.   ACTA NEUROPATHOLOGICA

Protective and Detrimental Roles for Regulatory T Cells in a Viral Model for Multiple Sclerosis

(2014) Nicholas E. Martinez et al.   BRAIN PATHOLOGY

Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE

(2014) H. Levy Barazany et al.   EXPERIMENTAL NEUROLOGY

The translational biology of remyelination: Past, present, and future

(2014) Robin J. M. Franklin et al.   GLIA

From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development

(2014) Avraham Ben-Nun et al.   JOURNAL OF AUTOIMMUNITY

Cutting Edge: Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

(2014) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination

(2014) Caroline A Blanc et al.   Journal of Neuroinflammation

The Charcot Lecture | Beating MS: A story of B cells, with twists and turns

(2014) Stephen L Hauser   Multiple Sclerosis Journal

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis

(2014) Aline Dumas et al.   PLoS Pathogens

Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain

(2014) Samira Saadoun et al.   Acta Neuropathologica Communications

Iron and neurodegeneration in the multiple sclerosis brain

(2013) Simon Hametner et al.   ANNALS OF NEUROLOGY

Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats

(2013) Christopher Gardner et al.   BRAIN

Disease-specific molecular events in cortical multiple sclerosis lesions

(2013) Marie Therese Fischer et al.   BRAIN

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

Remyelination: The True Regeneration of the Central Nervous System

(2013) A.H. Crawford et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator

(2013) Marsilius Mues et al.   NATURE MEDICINE

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis

(2013) David W Hampton et al.   Acta Neuropathologica Communications

T cell-activation in neuromyelitis optica lesions plays a role in their formation

(2013) Maria Pohl et al.   Acta Neuropathologica Communications

Oligodendrocytes Enforce Immune Tolerance of the Uninfected Brain by Purging the Peripheral Repertoire of Autoreactive CD8+ T Cells

(2012) Shin-Young Na et al.   IMMUNITY

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

(2012) Emily Pierson et al.   IMMUNOLOGICAL REVIEWS

A Transgenic Model of Central Nervous System Autoimmunity Mediated by CD4+ and CD8+ T and B Cells

(2012) A. C. Anderson et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus

(2012) T. Scheikl et al.   JOURNAL OF IMMUNOLOGY

Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro

(2012) Robert P. Lisak et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroprotection and repair in multiple sclerosis

(2012) Robin J. M. Franklin et al.   Nature Reviews Neurology

Late motor decline after accomplished remyelination: Impact for progressive multiple sclerosis

(2011) Natalia Manrique-Hoyos et al.   ANNALS OF NEUROLOGY

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Publication guidelines for refereeing and reporting on animal use in experimental autoimmune encephalomyelitis

(2011) David Baker et al.   JOURNAL OF NEUROIMMUNOLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Age and disability accumulation in multiple sclerosis

(2011) A. Scalfari et al.   NEUROLOGY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination

(2010) Rakhi Sharma et al.   ACTA NEUROPATHOLOGICA

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

(2010) Samira Saadoun et al.   BRAIN

Age-Related and Cuprizone-Induced Changes in Myelin and Transcription Factor Gene Expression and in Oligodendrocyte Cell Densities in the Rostral Corpus Callosum of Mice

(2010) J. Ronald Doucette et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Characterization of brain lesions in a mouse model of progressive multiple sclerosis

(2010) H. Levy et al.   EXPERIMENTAL NEUROLOGY

Pathogenesis of Murine Coronavirus in the Central Nervous System

(2010) Susan J. Bender et al.   Journal of Neuroimmune Pharmacology

Plasma cells in the central nervous system in the Theiler's virus model of multiple sclerosis

(2010) Andrew R. Pachner et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo

(2009) Monika Bradl et al.   ANNALS OF NEUROLOGY

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells

(2009) Bernadette Pöllinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Initiation and Progression of Axonopathy in Experimental Autoimmune Encephalomyelitis

(2009) A. M. Soulika et al.   JOURNAL OF NEUROSCIENCE

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis

(2009) Gurumoorthy Krishnamoorthy et al.   NATURE MEDICINE

Neuromyelitis optica with intraspinal expansion of Schwann cell remyelination

(2009) Hayato Ikota et al.   NEUROPATHOLOGY

Naïve CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system

(2008) Shin-Young Na et al.   BRAIN

Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis

(2008) J. M. Anderson et al.   BRAIN

Mitochondrial defects in acute multiple sclerosis lesions

(2008) Don Mahad et al.   BRAIN

Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis

(2008) Alexandre S. Basso et al.   JOURNAL OF CLINICAL INVESTIGATION

Pertussis toxin induces angiogenesis in brain microvascular endothelial cells

(2008) Changming Lu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

(2008) Manuel A Friese et al.   NATURE MEDICINE

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

(2008) Siming Shen et al.   NATURE NEUROSCIENCE

Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments

(2008) Ruth Huizinga et al.   NEUROBIOLOGY OF DISEASE

Cortical demyelination in PML and MS: Similarities and differences

(2007) N. M. Moll et al.   NEUROLOGY