Small Heat Shock Proteins and Human Neurodegenerative Diseases

Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation

(2019) Shen-zhao Lu et al.   Translational Neurodegeneration

Mechanisms of Small Heat Shock Proteins

(2019) Maria K. Janowska et al.   Cold Spring Harbor Perspectives in Biology

Amyloid found in human cataracts with two-dimensional infrared spectroscopy

(2019) Ariel M. Alperstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies

(2019) Mansour Haidar et al.   Autophagy

Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation by ATP-Independent Molecular Chaperones: Lens α-Crystallins and Milk Caseins

(2018) John A. Carver et al.   ACCOUNTS OF CHEMICAL RESEARCH

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

(2018) Dezerae Cox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

(2018) Hannah E. R. Baughman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine

(2018) Jonathan B. Rothbard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases

(2018) Stephen D. Weeks et al.   Scientific Reports

Probable Participation of 14-3-3 in Tau Protein Oligomerization and Aggregation

(2018) Nikolai N. Sluchanko et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Phosphorylation, Molecular Chaperones, and Ubiquitin E3 Ligase: Clinical Relevance in Alzheimer's Disease

(2018) Pravir Kumar et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization

(2018) Zhenying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic profile and onset features of 1005 patients with Charcot-Marie-Tooth disease in Japan

(2018) Akiko Yoshimura et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies

(2018) Jonathan B. Rothbard et al.   Cold Spring Harbor Perspectives in Medicine

Co-chaperoning by amyloid-forming proteins: cystatins vs. crystallins

(2017) Eva Žerovnik   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations

(2017) Andoni Echaniz-Laguna et al.   HUMAN MUTATION

Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1

(2017) Michelle Heirbaut et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator

(2017) Nikolai N. Sluchanko et al.   STRUCTURE

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

(2017) Paola Rusmini et al.   Frontiers in Molecular Neuroscience

Atypical, non-standard functions of the microtubule associated Tau protein

(2017) Ioannis Sotiropoulos et al.   Acta Neuropathologica Communications

Towards a functional pathology of hereditary neuropathies

(2016) Joachim Weis et al.   ACTA NEUROPATHOLOGICA

Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson’s disease

(2016) Sandeep K. Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation

(2016) Dezerae Cox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot–Marie–Tooth Disease

(2016) Veronick Benoy et al.   Neurotherapeutics

A Mechanism of Subunit Recruitment in Human Small Heat Shock Protein Oligomers

(2015) Scott P. Delbecq et al.   BIOCHEMISTRY

Small heat shock proteins: Role in cellular functions and pathology

(2015) Raman Bakthisaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Phosphomimics Destabilize Hsp27 Oligomeric Assemblies and Enhance Chaperone Activity

(2015) Blagojce Jovcevski et al.   CHEMISTRY & BIOLOGY

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial dynamics and inherited peripheral nerve diseases

(2015) Davide Pareyson et al.   NEUROSCIENCE LETTERS

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases

(2015) Lydia K. Muranova et al.   PLoS One

Preventing α-synuclein aggregation: The role of the small heat-shock molecular chaperone proteins

(2014) Dezerae Cox et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Characterization of human small heat shock protein HspB1 that carries C-terminal domain mutations associated with hereditary motor neuron diseases

(2014) Anna S. Chalova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death

(2014) Ryan T. Cameron et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The metazoan protein disaggregase and amyloid depolymerase system

(2014) Mariana P Torrente et al.   Prion

Dynamical structure of αB-crystallin

(2014) Georg K.A. Hochberg et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Heat shock proteins in neurodegenerative disorders and aging

(2014) Rehana K. Leak   Journal of Cell Communication and Signaling

Charcot–Marie–Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments

(2013) Anne Holmgren et al.   ACTA NEUROPATHOLOGICA

Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy

(2013) Victoria V. Nefedova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies

(2013) Victoria V. Nefedova et al.   BIOCHIMIE

Abnormally Upregulated αB-crystallin Was Highly Coincidental with the Astrogliosis in the Brains of Scrapie-Infected Hamsters and Human Patients with Prion Diseases

(2013) Ke Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the ‘IxI’ motif

(2012) Scott P Delbecq et al.   EMBO JOURNAL

sHSP in the eye lens: Crystallin mutations, cataract and proteostasis

(2012) Alice R. Clark et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier–dependent pathway

(2012) Annette Ahner et al.   MOLECULAR BIOLOGY OF THE CELL

Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice

(2012) Amit K. Srivastava et al.   NEUROBIOLOGY OF DISEASE

Charcot–Marie–Tooth disease and intracellular traffic

(2012) Cecilia Bucci et al.   PROGRESS IN NEUROBIOLOGY

Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans

(2012) Martin L. Duennwald et al.   PLOS BIOLOGY

Charcot-marie-tooth disease subtypes and genetic testing strategies

(2011) Anita S.D. Saporta et al.   ANNALS OF NEUROLOGY

Biochemical characterization of small heat shock protein HspB8 (Hsp22)–Bag3 interaction

(2011) Anton A. Shemetov et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Heterooligomeric complexes of human small heat shock proteins

(2011) Evgeny V. Mymrikov et al.   CELL STRESS & CHAPERONES

Three-Dimensional Structure of α-Crystallin Domain Dimers of Human Small Heat Shock Proteins HSPB1 and HSPB6

(2011) E.V. Baranova et al.   JOURNAL OF MOLECULAR BIOLOGY

Small Heat-Shock Protein HSPB1 Mutants Stabilize Microtubules in Charcot-Marie-Tooth Neuropathy

(2011) L. Almeida-Souza et al.   JOURNAL OF NEUROSCIENCE

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Large Potentials of Small Heat Shock Proteins

(2011) Evgeny V. Mymrikov et al.   PHYSIOLOGICAL REVIEWS

Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins

(2011) Serena Carra et al.   PROGRESS IN NEUROBIOLOGY

Phosphomimicking mutations of human 14-3-3ζ affect its interaction with tau protein and small heat shock protein HspB6

(2010) Nikolai N. Sluchanko et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Analyzing Histopathological Features of Rare Charcot-Marie-Tooth Neuropathies to Unravel Their Pathogenesis

(2010) Sara Benedetti et al.   ARCHIVES OF NEUROLOGY

Identification of theDrosophilaOrtholog of HSPB8

(2010) Serena Carra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice

(2010) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

Effect of phosphorylation on interaction of human tau protein with 14-3-3ζ

(2009) Nikolai N. Sluchanko et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3ζ

(2009) Nikolai N. Sluchanko et al.   FEBS LETTERS

Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20

(2009) C. Bagnéris et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid Fibril Formation and Chaperone-like Activity of Peptides from αA-Crystallin†

(2008) Naoki Tanaka et al.   BIOCHEMISTRY

Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†

(2008) Michel J. Vos et al.   BIOCHEMISTRY

Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation

(2008) Golam Sadik et al.   JOURNAL OF NEUROCHEMISTRY