The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

A First Line of Stress Defense: Small Heat Shock Proteins and Their Function in Protein Homeostasis

(2015) Martin Haslbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

(2014) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small heat-shock proteins: important players in regulating cellular proteostasis

(2014) Teresa M. Treweek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The structured core domain of  B-crystallin can prevent amyloid fibrillation and associated toxicity

(2014) G. K. A. Hochberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamical structure of αB-crystallin

(2014) Georg K.A. Hochberg et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

NMR Spectroscopy of Soluble Protein Complexes at One Mega-Dalton and Beyond

(2013) Andi Mainz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One size does not fit all: The oligomeric states of αB crystallin

(2013) Scott P. Delbecq et al.   FEBS LETTERS

Cryoelectron Microscopy Analysis of Small Heat Shock Protein 16.5 (Hsp16.5) Complexes with T4 Lysozyme Reveals the Structural Basis of Multimode Binding

(2013) Jian Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal interactions mediate the quaternary dynamics of  B-crystallin

(2013) G. R. Hilton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulated structural transitions unleash the chaperone activity of  B-crystallin

(2013) J. Peschek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The small heat-shock protein αB-crystallin uses different mechanisms of chaperone action to prevent the amorphous versus fibrillar aggregation of α-lactalbumin

(2012) Melissa Kulig et al.   BIOCHEMICAL JOURNAL

Amyloid-β Oligomers are Sequestered by both Intracellular and Extracellular Chaperones

(2012) Priyanka Narayan et al.   BIOCHEMISTRY

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the ‘IxI’ motif

(2012) Scott P Delbecq et al.   EMBO JOURNAL

Probing Dynamic Conformations of the High-Molecular-Weight αB-Crystallin Heat Shock Protein Ensemble by NMR Spectroscopy

(2012) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation

(2011) Sarah L. Shammas et al.   BIOPHYSICAL JOURNAL

Bacterial Inclusion Bodies of Alzheimer's Disease β-Amyloid Peptides Can Be Employed To Study Native-Like Aggregation Intermediate States

(2011) Muralidhar Dasari et al.   CHEMBIOCHEM

Structural and Mechanistic Implications of Metal Binding in the Small Heat-shock Protein αB-crystallin

(2011) Andi Mainz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus

(2011) Andrew J. Baldwin et al.   JOURNAL OF MOLECULAR BIOLOGY

αB-Crystallin Polydispersity Is a Consequence of Unbiased Quaternary Dynamics

(2011) Andrew J. Baldwin et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of R120G Disease Mutant of Human αB-Crystallin Domain Dimer Shows Closure of a Groove

(2011) A.R. Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Multiple Sites in αB-Crystallin Modulate Its Interactions with Desmin Filaments Assembled In Vitro

(2011) Scott A. Houck et al.   PLoS One

Solid-state NMR of proteins sedimented by ultracentrifugation

(2011) I. Bertini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal domain of  B-crystallin provides a conformational switch for multimerization and structural heterogeneity

(2011) S. Jehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple molecular architectures of the eye lens chaperone  B-crystallin elucidated by a triple hybrid approach

(2011) N. Braun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Polydispersity of αB-Crystallin Is Rationalized by an Interconverting Polyhedral Architecture

(2011) Andrew J. Baldwin et al.   STRUCTURE

The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

(2010) Christopher A. Waudby et al.   BIOPHYSICAL JOURNAL

A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, αA- and αB-crystallin

(2010) Teresa M. Treweek et al.   EXPERIMENTAL EYE RESEARCH

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

(2010) Stefan Jehle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

(2010) Arthur Laganowsky et al.   PROTEIN SCIENCE

Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20

(2009) C. Bagnéris et al.   JOURNAL OF MOLECULAR BIOLOGY

Large Protein Complexes with Extreme Rotational Correlation Times Investigated in Solution by Magic-Angle-Spinning NMR Spectroscopy

(2009) Andi Mainz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate binding site flexibility of the small heat shock protein molecular chaperones

(2009) N. Jaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha crystallin: The quest for a homogeneous quaternary structure

(2008) Joseph Horwitz   EXPERIMENTAL EYE RESEARCH

High-performance solvent suppression for proton detected solid-state NMR

(2008) Donghua H. Zhou et al.   JOURNAL OF MAGNETIC RESONANCE

αB-Crystallin: A Hybrid Solid-State/Solution-State NMR Investigation Reveals Structural Aspects of the Heterogeneous Oligomer

(2008) Stefan Jehle et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Phosphorylation on αB-crystallin: Differences in Stability, Subunit Exchange and Chaperone Activity of Homo and Mixed Oligomers of αB-Crystallin and its Phosphorylation-mimicking Mutant

(2007) Md. Faiz Ahmad et al.   JOURNAL OF MOLECULAR BIOLOGY