Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prions are a common mechanism for phenotypic inheritance in wild yeasts

(2012) Randal Halfmann et al.   NATURE

A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress

(2012) G. Suzuki et al.   SCIENCE

Heat shock protein 104 inhibited the fibrillization of prion peptide 106–126 and disassembled prion peptide 106–126 fibrils in vitro

(2011) Ying-Hui Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hsp42 is required for sequestration of protein aggregates into deposition sites inSaccharomyces cerevisiae

(2011) Sebastian Specht et al.   JOURNAL OF CELL BIOLOGY

Aβ40 and Aβ42 Amyloid Fibrils Exhibit Distinct Molecular Recycling Properties

(2011) Laia Sánchez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanomechanics of functional and pathological amyloid materials

(2011) Tuomas P. J. Knowles et al.   Nature Nanotechnology

Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation

(2011) Susanne DiSalvo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

Suicidal [PSI+] is a lethal yeast prion

(2011) R. P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Intermolecular Dynamics of Aggregates Populated during Amyloid Fibril Formation Studied by Hydrogen/Deuterium Exchange

(2010) Natàlia Carulla et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

(2010) Christopher A. Waudby et al.   BIOPHYSICAL JOURNAL

Immobilization of organophosphate hydrolase on an amyloid fibril nanoscaffold: Towards bioremediation and chemical detoxification

(2010) Jared K. Raynes et al.   BIOTECHNOLOGY PROGRESS

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

(2010) Kausik Si et al.   CELL

The Quaternary Organization and Dynamics of the Molecular Chaperone HSP26 Are Thermally Regulated

(2010) Justin L.P. Benesch et al.   CHEMISTRY & BIOLOGY

Prion-like disorders: blurring the divide between transmissibility and infectivity

(2010) M. Cushman et al.   JOURNAL OF CELL SCIENCE

Nanostructured films from hierarchical self-assembly of amyloidogenic proteins

(2010) Tuomas P. J. Knowles et al.   Nature Nanotechnology

Optical trapping with high forces reveals unexpected behaviors of prion fibrils

(2010) Jijun Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prion proteostasis

(2010) Elizabeth A. Sweeny et al.   Prion

Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation

(2010) J. Tyedmers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identifying the amylome, proteins capable of forming amyloid-like fibrils

(2010) Lukasz Goldschmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Dynamics within Amyloid Fibrils Using a Novel Capping Method

(2009) Geoffrey W. Platt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure and Mechanism of Protein Stability Sensors: Chaperone Activity of Small Heat Shock Proteins

(2009) Hassane S. Mchaourab et al.   BIOCHEMISTRY

N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils

(2009) Brenda Watt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

(2009) Lynette Cegelski et al.   Nature Chemical Biology

A synergistic small-molecule combination directly eradicates diverse prion strain structures

(2009) Blake E Roberts et al.   Nature Chemical Biology

A kinetic assessment of theC. elegansamyloid disaggregation activity enables uncoupling of disassembly and proteolysis

(2009) Jan Bieschke et al.   PROTEIN SCIENCE

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Prion-associated proteins in yeast: comparative analysis of isogenic [PSI+] and [psi−] strains

(2009) Olga V. Nevzglyadova et al.   YEAST

Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance

(2008) Anders Olofsson et al.   ANALYTICAL BIOCHEMISTRY

Crystallin proteins and amyloid fibrils

(2008) H. Ecroyd et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

(2008) James Shorter et al.   EMBO JOURNAL

Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

(2008) Christophe Lo Bianco et al.   JOURNAL OF CLINICAL INVESTIGATION

Variant-specific [PSI+] Infection Is Transmitted by Sup35 Polymers within [PSI+] Aggregates with Heterogeneous Protein Composition

(2008) Sviatoslav N. Bagriantsev et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of the Chaperone Hsp26 Is Controlled by the Rearrangement of Its Thermosensor Domain

(2008) Titus M. Franzmann et al.   MOLECULAR CELL

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiae by Two Discrete Activities

(2008) Heather Sadlish et al.   PLoS One

Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs

(2008) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-dependent amyloid assembly protects cells from prion toxicity

(2008) P. M. Douglas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid as a Depot for the Formulation of Long-Acting Drugs

(2008) Samir K Maji et al.   PLOS BIOLOGY

Prion Switching in Response to Environmental Stress

(2008) Jens Tyedmers et al.   PLOS BIOLOGY