HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

(2017) Jennifer N. Rauch et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

(2016) Sarah N Fontaine et al.   EMBO JOURNAL

The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation

(2016) Ali Chaari et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation

(2016) Dezerae Cox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

(2015) Sayuri Taniguchi-Watanabe et al.   ACTA NEUROPATHOLOGICA

Phosphomimics Destabilize Hsp27 Oligomeric Assemblies and Enhance Chaperone Activity

(2015) Blagojce Jovcevski et al.   CHEMISTRY & BIOLOGY

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

(2015) Sarah N. Fontaine et al.   HUMAN MOLECULAR GENETICS

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis

(2015) Ponni Rajagopal et al.   eLife

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

(2014) G. Elif Karagöz et al.   CELL

Small heat-shock proteins: important players in regulating cellular proteostasis

(2014) Teresa M. Treweek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The structured core domain of  B-crystallin can prevent amyloid fibrillation and associated toxicity

(2014) G. K. A. Hochberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSPA8/HSC70 chaperone protein

(2013) François Stricher et al.   Autophagy

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

(2013) Jose Abisambra et al.   BIOLOGICAL PSYCHIATRY

Protein Disulfide Isomerase Interacts with Tau Protein and Inhibits Its Fibrillization

(2013) Li-Rong Xu et al.   PLoS One

Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation

(2013) Patrick Barré et al.   PROTEIN SCIENCE

Sequence, Structure, and Dynamic Determinants of Hsp27 (HspB1) Equilibrium Dissociation Are Encoded by the N-Terminal Domain

(2012) Ezelle T. McDonald et al.   BIOCHEMISTRY

Hsp70 Alters Tau Function and Aggregation in an Isoform Specific Manner

(2012) Kellen Voss et al.   BIOCHEMISTRY

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the ‘IxI’ motif

(2012) Scott P Delbecq et al.   EMBO JOURNAL

Imbalance of Hsp70 family variants fosters tau accumulation

(2012) Umesh K. Jinwal et al.   FASEB JOURNAL

Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability

(2012) Katharina Flach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing Dynamic Conformations of the High-Molecular-Weight αB-Crystallin Heat Shock Protein Ensemble by NMR Spectroscopy

(2012) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Sheet Core of Tau Paired Helical Filaments Revealed by Solid-State NMR

(2012) Venita Daebel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Roles of the N- and C-terminal sequences in Hsp27 self-association and chaperone activity

(2011) Barbara Lelj-Garolla et al.   PROTEIN SCIENCE

Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions

(2011) Eman Basha et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice

(2010) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

Automatic Assignment of the Intrinsically Disordered Protein Tau with 441-Residues

(2010) Rhagavendran L. Narayanan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Tau Mutations in Neurodegenerative Diseases

(2008) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY