Impact of pharmacological agents on mitochondrial function: a growing opportunity?

Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis

(2019) Mark V Pinti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

(2019) S. A. Baechler et al.   Nature Communications

Mitochondria: the indispensable players in innate immunity and guardians of the inflammatory response

(2019) Abhishek Mohanty et al.   Journal of Cell Communication and Signaling

Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

(2019) Dmitri Rozanov et al.   PLoS One

Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer

(2019) Helai P. Mohammad et al.   NATURE MEDICINE

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

(2019) Yufeng Shi et al.   NATURE

Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs

(2019) Laura C. Kelley et al.   DEVELOPMENTAL CELL

Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues

(2019) Paul R. Graves et al.   ACS Chemical Biology

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

(2019) Jo Ishizawa et al.   CANCER CELL

MYC REGULATION OF A MITOCHONDRIAL TRAFFICKING NETWORK MEDIATES TUMOR CELL INVASION AND METASTASIS

(2019) Ekta Agarwal et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

(2019) Liang Zhang et al.   Science Translational Medicine

Mitochondria—Striking a balance between host and endosymbiont

(2019) Richard J. Youle   SCIENCE

Mechanisms, pathophysiological roles and methods for analyzing mitophagy – recent insights

(2018) Jessica A. Williams et al.   BIOLOGICAL CHEMISTRY

The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism

(2018) Senta M. Kapnick et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

ONC201 kills breast cancer cells in vitro by targeting mitochondria

(2018) Yoshimi Endo Greer et al.   Oncotarget

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2

(2018) Anu Hangas et al.   NUCLEIC ACIDS RESEARCH

Targeting mitochondria in cancer: current concepts and immunotherapy approaches

(2018) Sergey Pustylnikov et al.   Translational Research

Metabolic Profiles Associated With Metformin Efficacy in Cancer

(2018) Sylvia Andrzejewski et al.   Frontiers in Endocrinology

Mitochondrial dynamics and metastasis

(2018) Dario C. Altieri   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

(2018) Matilda Lee et al.   Redox Biology

Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ

(2017) John D. Widdrington et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer

(2017) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

Ketogenic diet in pyruvate dehydrogenase complex deficiency: short- and long-term outcomes

(2017) Kalliopi Sofou et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondria and mitochondria-induced signalling molecules as longevity determinants

(2017) Giuseppina Rose et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial dysfunction and potential anticancer therapy

(2017) Matilde E. Lleonart et al.   MEDICINAL RESEARCH REVIEWS

Myotoxicity of statins: Mechanism of action

(2017) Patrick du Souich et al.   PHARMACOLOGY & THERAPEUTICS

The Mitochondrial Basis of Aging and Age-Related Disorders

(2017) Sarika Srivastava   Genes

Statins, Muscle Disease and Mitochondria

(2017) Radha Ramachandran et al.   Journal of Clinical Medicine

Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects

(2017) Marie-Laure Crouch et al.   PLoS One

Modulating Mitophagy in Mitochondrial Disease

(2017) Eszter Dombi et al.   CURRENT MEDICINAL CHEMISTRY

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

The quantum mitochondrion and optimal health

(2016) A. V. W. Nunn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of mitochondrial DNA variation in the pathogenesis of diabetes mellitus

(2016) Kyong Soo Park   Frontiers in Bioscience-Landmark

Mitophagy plays a central role in mitochondrial ageing

(2016) Alan Diot et al.   MAMMALIAN GENOME

A neuronal network of mitochondrial dynamics regulates metastasis

(2016) M. Cecilia Caino et al.   Nature Communications

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

(2016) Thomas M. Ashton et al.   Nature Communications

Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo

(2016) Michael Y. Bonner et al.   Oncotarget

Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models

(2016) Chien Tai Hong et al.   Scientific Reports

Mitochondrial dynamics and viral infections: A close nexus

(2015) Mohsin Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation

(2015) Ji-Hee Won et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The impact of moderate wine consumption on health

(2015) Ana Artero et al.   MATURITAS

Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity

(2015) Anna Maria D'Erchia et al.   MITOCHONDRION

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response

(2015) Dmitri Rozanov et al.   PLoS One

Mitochondrial DNA in the regulation of innate immune responses

(2015) Chunju Fang et al.   Protein & Cell

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

PET Imaging to Monitor Cancer Therapy

(2014) Gaurav Malviya et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair

(2014) Suhong Xu et al.   DEVELOPMENTAL CELL

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

(2014) Yvonne Will et al.   Expert Opinion on Drug Metabolism & Toxicology

A mitochondrial bioenergetic basis of depression

(2014) N. Jennifer Klinedinst et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial trafficking and anchoring in neurons: New insight and implications

(2014) Zu-Hang Sheng   JOURNAL OF CELL BIOLOGY

UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

(2014) A. Vozza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOR Signaling Couples Oxygen Sensing to Lifespan in C. elegans

(2014) Michael Schieber et al.   Cell Reports

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

(2014) Young Seok Ju et al.   eLife

The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle

(2013) Laura A.A. Gilliam et al.   FREE RADICAL BIOLOGY AND MEDICINE

Preventing the transmission of pathogenic mitochondrial DNA mutations: can we achieve long-term benefits from germ-line gene transfer?

(2013) D. C. Samuels et al.   HUMAN REPRODUCTION

Mitochondrial DNA Subhaplogroups L0a2 and L2a Modify Susceptibility to Peripheral Neuropathy in Malawian Adults on Stavudine Containing Highly Active Antiretroviral Therapy

(2013) Elizabeth Kampira et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism

(2013) Vishal M. Gohil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation

(2013) LAURA ASTOLFI et al.   ONCOLOGY REPORTS

Clozapine-Induced Mitochondria Alterations and Inflammation in Brain and Insulin-Responsive Cells

(2013) Verόnica Contreras-Shannon et al.   PLoS One

Doxycycline Alters Metabolism and Proliferation of Human Cell Lines

(2013) Ethan Ahler et al.   PLoS One

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

(2013) S. Kalghatgi et al.   Science Translational Medicine

Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

(2013) J. E. Allen et al.   Science Translational Medicine

The Role of Mitochondria in Cellular Iron-Sulfur Protein Biogenesis: Mechanisms, Connected Processes, and Diseases

(2013) O. Stehling et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial DNA damage induces apoptosis in senescent cells

(2013) R-M Laberge et al.   Cell Death & Disease

Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation

(2012) David Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting cancer cell mitochondria as a therapeutic approach

(2012) Shijun Wen et al.   Future Medicinal Chemistry

Mitochondrial antibiograms in personalized medicine

(2012) D. Pacheu-Grau et al.   HUMAN MOLECULAR GENETICS

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Mitochondria and cell signalling

(2012) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent

(2012) Yan Li et al.   TOXICOLOGICAL SCIENCES

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

(2012) Claudia V. Pereira et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Signal Transduction by Mitochondrial Oxidants

(2011) Toren Finkel   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism

(2011) Sabrina Diano et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondria and Hypoxia-induced Gene Expression Mediated by Hypoxia-inducible Factors

(2010) Angela Chavez et al.   Annals of the New York Academy of Sciences

The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

(2010) Timothy Wai et al.   BIOLOGY OF REPRODUCTION

Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells

(2010) Jiunn-Min Shieh et al.   BRITISH JOURNAL OF PHARMACOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Meclizine is neuroprotective in models of Huntington's disease

(2010) V. M. Gohil et al.   HUMAN MOLECULAR GENETICS

Clozapine Treatment Causes Oxidation of Proteins Involved in Energy Metabolism in Lymphoblastoid Cells: A Possible Mechanism for Antipsychotic- Induced Metabolic Alterations

(2010) Muhammad R. Baig et al.   Journal of Psychiatric Practice

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The Effects of Antidepressants on Mitochondrial Function in a Model Cell System and Isolated Mitochondria

(2010) W. Abdel-Razaq et al.   NEUROCHEMICAL RESEARCH

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

Interaction of Aminoglycosides with Human Mitochondrial 12S rRNA Carrying the Deafness-Associated Mutation

(2009) Y. Qian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial Function, Morphology, and Axonal Transport in Amyotrophic Lateral Sclerosis

(2009) Jordi Magrané et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

(2009) Fulvio Celsi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure and function of mitochondrial supercomplexes

(2009) Natalya V. Dudkina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism?

(2009) Claire Pecqueur et al.   IUBMB LIFE

A Comparative Proteomics Analysis of Rat Mitochondria from the Cerebral Cortex and Hippocampus in Response to Antipsychotic Medications

(2009) Baohu Ji et al.   JOURNAL OF PROTEOME RESEARCH

Selective serotonin reuptake inhibitors pathway

(2009) Katrin Sangkuhl et al.   Pharmacogenetics and Genomics

DNA Polymerases as Therapeutic Targets†

(2008) Anthony J. Berdis   BIOCHEMISTRY

Clozapine causes oxidation of proteins involved in energy metabolism: a possible mechanism for antipsychotic-induced metabolic alterations

(2008) Consuelo Walss-Bass et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mitochondrial off targets of drug therapy

(2008) Kendall B. Wallace   TRENDS IN PHARMACOLOGICAL SCIENCES