Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes

(2018) Subhendu K. Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds

(2018) Balaraman Kalyanaraman et al.   Redox Biology

Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer

(2017) Amanda L. Jackson et al.   Oncotarget

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

(2016) Narciso Couto et al.   FREE RADICAL BIOLOGY AND MEDICINE

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile

(2015) Federica Prati et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response

(2015) Dmitri Rozanov et al.   PLoS One

NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell

(2015) Fan Chen et al.   Protein & Cell

Pharmacological Applications of Antioxidants: Lights and Shadows

(2014) Luciano Saso et al.   CURRENT DRUG TARGETS

Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives

(2014) Veda Prachayasittikul et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GAPDH: the missing link between glycolysis and mitochondrial oxidative phosphorylation?

(2013) Rabia Ramzan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Antiproliferative activities and SAR studies of substituted anthraquinones and 1,4-naphthoquinones

(2013) Deepak Bhasin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells

(2013) Suthananda N. Sunassee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma

(2013) P. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

Thioredoxin System in Cell Death Progression

(2012) Jun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

(2012) J. W. Tyner et al.   CANCER RESEARCH

Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death

(2012) G. Cheng et al.   CANCER RESEARCH

Plumbagin, a medicinal plant (lumbago zeylanica )-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model

(2012) Bilal Bin Hafeez et al.   Molecular Oncology

Genetic determinants of oxidative stress-mediated sensitization of drug-resistant cancer cells

(2011) Amit K. Maiti   INTERNATIONAL JOURNAL OF CANCER

Virtual Ligand Screening of the National Cancer Institute (NCI) Compound Library Leads to the Allosteric Inhibitory Scaffolds of the West Nile Virus NS3 Proteinase

(2010) Sergey A. Shiryaev et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents

(2010) Julio Benites et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide

(2010) Yang Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis

(2009) Tomoko Kayashima et al.   CANCER LETTERS

In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway

(2008) Ruifen Zhang et al.   APOPTOSIS

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

(2008) Jeffrey A Engelman et al.   NATURE MEDICINE

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase

(2008) Christophe Morin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY