Statins, Muscle Disease and Mitochondria

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

Myotoxicity of statins: Mechanism of action

(2017) Patrick du Souich et al.   PHARMACOLOGY & THERAPEUTICS

Statin myopathy

(2016) Negar Maghsoodi et al.   CURRENT OPINION IN CARDIOLOGY

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Mohammad H Forouzanfar et al.   LANCET

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

GATM Polymorphism Associated with the Risk for Statin-Induced Myopathy Does Not Replicate in Case-Control Analysis of 715 Dyslipidemic Individuals

(2015) Jasmine A. Luzum et al.   Cell Metabolism

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

(2015) Erik S. Stroes et al.   EUROPEAN HEART JOURNAL

The role of mitochondria in statin-induced myopathy

(2015) Maria Apostolopoulou et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Risk identification and possible countermeasures for muscle adverse effects during statin therapy

(2015) Paolo Magni et al.   European Journal of Internal Medicine

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

(2015) Maciej Banach et al.   Expert Opinion On Drug Safety

Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients

(2015) Marta Michalska-Kasiczak et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Statin induced necrotizing autoimmune myopathy

(2015) Suma Babu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effects of Coenzyme Q10 on Statin-Induced Myopathy

(2015) Maciej Banach et al.   MAYO CLINIC PROCEEDINGS

Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content

(2015) Craig A. Goodman et al.   PLoS One

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

(2014) Annalisa Bonifacio et al.   ARCHIVES OF TOXICOLOGY

Phenotype Standardization for Statin-Induced Myotoxicity

(2014) A Alfirevic et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mitochondrial dysfunction as a central event for mechanisms underlying insulin resistance: the roles of long chain fatty acids

(2014) Mohamad Hafizi Abu Bakar et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Statin-induced muscle toxicity and susceptibility to malignant hyperthermia and other muscle diseases: a population-based case-control study including 1st and 2nd degree relatives

(2014) Karin Hedenmalm et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review

(2014) William J. Canestaro et al.   GENETICS IN MEDICINE

Addressing Statin Adverse Effects in the Clinic

(2014) Daniel H. Katz et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

An assessment by the Statin Muscle Safety Task Force: 2014 update

(2014) Robert S. Rosenson et al.   Journal of Clinical Lipidology

Genetic bases and clinical manifestations of coenzyme Q10 (CoQ10) deficiency

(2014) Maria Andrea Desbats et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Lipid modification and cardiovascular risk assessment for the primary and secondary prevention of cardiovascular disease: summary of updated NICE guidance

(2014) S. Rabar et al.   BMJ-British Medical Journal

Discontinuation of Statins in Routine Care Settings

(2013) Huabing Zhang et al.   ANNALS OF INTERNAL MEDICINE

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Working Group Consensus Update

(2013) G.B. John Mancini et al.   CANADIAN JOURNAL OF CARDIOLOGY

Comparative Tolerability and Harms of Individual Statins

(2013) Huseyin Naci et al.  

Ubiquinol rescues simvastatin-suppression of mitochondrial content, function and metabolism: Implications for statin-induced rhabdomyolysis

(2013) Roger A. Vaughan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Simvastatin Effects on Skeletal Muscle

(2013) Steen Larsen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Decreased skeletal muscle mitochondrial DNA in patients with statin-induced myopathy

(2013) Henry A.J. Stringer et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

(2013) Lara M. Mangravite et al.   NATURE

Dose-comparative effects of different statins on serum lipid levels: a network meta-analysis of 256,827 individuals in 181 randomized controlled trials

(2013) Huseyin Naci et al.   European Journal of Preventive Cardiology

Effect of Statins on Skeletal Muscle Function

(2012) Beth A. Parker et al.   CIRCULATION

Predicting the adverse risk of statin treatment: an independent and external validation of Qstatin risk scores in the UK

(2012) Gary S Collins et al.   HEART

Understanding Statin Use in America and Gaps in Patient Education (USAGE): An internet-based survey of 10,138 current and former statin users

(2012) Jerome D. Cohen et al.   Journal of Clinical Lipidology

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents

(2012) Joanne E. Mallinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

(2011) Peter J. Mullen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

What is a relevant statin concentration in cell experiments claiming pleiotropic effects?

(2011) Linda Björkhem-Bergman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Lapaquistat Acetate

(2011) Evan A. Stein et al.   CIRCULATION

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

(2011) Jamal Bouitbir et al.   EUROPEAN HEART JOURNAL

Lessons from Lipitor and the broken blockbuster drug model

(2011) The Lancet   LANCET

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation

(2011) R.A. Mans et al.   NEUROSCIENCE

Cerivastatin, genetic variants, and the risk of rhabdomyolysis

(2011) Kristin D. Marciante et al.   Pharmacogenetics and Genomics

Statin Therapy and the Expression of Genes that Regulate Calcium Homeostasis and Membrane Repair in Skeletal Muscle

(2010) Annette Draeger et al.   AMERICAN JOURNAL OF PATHOLOGY

Rosuvastatin Lowers Coenzyme Q10 Levels, but not Mitochondrial Adenosine Triphosphate Synthesis, in Children with Familial Hypercholesterolemia

(2010) Hans J. Avis et al.   JOURNAL OF PEDIATRICS

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Immune-mediated necrotizing myopathy associated with statins

(2009) Phyllis Grable-Esposito et al.   MUSCLE & NERVE

New insights into mechanisms of statin-associated myotoxicity

(2008) P SIRVENT et al.   CURRENT OPINION IN PHARMACOLOGY

Statin safety and chronic liver disease

(2008) J. Cash et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Myotoxicity of Lipid-Lowering Agents in a Teenager With MELAS Mutation

(2008) Stacey K.H. Tay et al.   PEDIATRIC NEUROLOGY

Rosuvastatin: Characterization of Induced Myopathy in the Rat

(2008) F. Russell Westwood et al.   TOXICOLOGIC PATHOLOGY

Decreased Ubiquinone Availability and Impaired Mitochondrial Cytochrome Oxidase Activity Associated With Statin Treatment

(2008) Andrew J. Duncan et al.   TOXICOLOGY MECHANISMS AND METHODS