Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis

Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer’s Disease

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ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

(2019) Joseph R. Klim et al.   NATURE NEUROSCIENCE

Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

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Splicing repression is a major function of TDP-43 in motor neurons

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Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis

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Neurofilament light: A candidate biomarker of pre-symptomatic ALS and phenoconversion

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Pathomechanisms of TDP-43 in neurodegeneration

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The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor

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Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

(2018) Erin G Conlon et al.   eLife

Secretory Leukocyte Protease Inhibitor Protein Regulates the Penetrance of Frontotemporal Lobar Degeneration in Progranulin Mutation Carriers

(2018) Roberta Ghidoni et al.   JOURNAL OF ALZHEIMERS DISEASE

Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase

(2018) Patrick Oeckl et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Deep Dive on the Proteome of Human Cerebrospinal Fluid: A Valuable Data Resource for Biomarker Discovery and Missing Protein Identification

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The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

(2018) Elizabeth B. Moloney et al.   NEUROBIOLOGY OF DISEASE

A matter of balance

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Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages

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Nesfatin-130-59 Injected Intracerebroventricularly Increases Anxiety, Depression-Like Behavior, and Anhedonia in Normal Weight Rats

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Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS

(2018) Michael S. Bereman et al.   Scientific Reports

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

(2018) Melanie Hüttenrauch et al.   Acta Neuropathologica Communications

The histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae

(2017) Lauren T. Neves et al.   GENES & DEVELOPMENT

Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression

(2017) Petra Steinacker et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients

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ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

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Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction

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Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis

(2016) Xueping Chen et al.   BMC Neurology

GPNMB ameliorates mutant TDP-43-induced motor neuron cell death

(2016) Yuki Nagahara et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer′s and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies

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The Perseus computational platform for comprehensive analysis of (prote)omics data

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Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS

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Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase

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Absence of UCHL 1 function leads to selective motor neuropathy

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Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau

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Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

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Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis

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Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

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Whole Exome Sequencing in Females with Autism Implicates Novel and Candidate Genes

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Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93Amouse model of amyotrophic lateral sclerosis

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A comprehensive map and functional annotation of the normal human cerebrospinal fluid proteome

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Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis

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A revision of the El Escorial criteria - 2015

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Angiotensin-Converting Enzyme Inhibitors and Amyotrophic Lateral Sclerosis Risk

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Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

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Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones

(2014) J. Robin Highley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Phosphorylated Tau as a Candidate Biomarker for Amyotrophic Lateral Sclerosis

(2014) Murray Grossman et al.   JAMA Neurology

Ubiquitin pathways in neurodegenerative disease

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Characterization of human sporadic ALS biomarkers in the familial ALS transgenic mSOD1G93A mouse model

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Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

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The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis

(2012) Hirotaka Tanaka et al.   Scientific Reports

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

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DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

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Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability

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Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

(2010) Laura E. Cox et al.   PLoS One

Reduction of Circulating Endothelial Cells in Peripheral Blood of ALS Patients

(2010) Svitlana Garbuzova-Davis et al.   PLoS One

Signal Regulatory Protein-β1

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Reduced angiotensin II levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

(2008) M. Kawajiri et al.   ACTA NEUROLOGICA SCANDINAVICA

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Proteome analysis of human substantia nigra in Parkinson's disease

(2008) Cornelius J Werner et al.   Proteome Science