Ubiquitin pathways in neurodegenerative disease

F-box Only Protein 2 (Fbxo2) Regulates Amyloid Precursor Protein Levels and Processing

(2014) Graham Atkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neuropathology associated with repeat expansions in the C9ORF72 gene

(2013) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Therapeutic induction of autophagy to modulate neurodegenerative disease progression

(2013) Warren E Hochfeld et al.   ACTA PHARMACOLOGICA SINICA

Parkin overexpression ameliorates hippocampal long-term potentiation and  -amyloid load in an Alzheimer's disease mouse model

(2013) X. Hong et al.   HUMAN MOLECULAR GENETICS

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders

(2013) J. Janssens et al.   HUMAN MOLECULAR GENETICS

Bidirectional Control of Postsynaptic Density-95 (PSD-95) Clustering by Huntingtin

(2013) Matthew P. Parsons et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1

(2013) Wayne W. Poon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin-conjugating Enzyme (E2) Ube2w Ubiquitinates the N Terminus of Substrates

(2013) Kenneth Matthew Scaglione et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

(2013) Li Zhang et al.   JOURNAL OF LIPID RESEARCH

Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor

(2013) Sajjad Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance

(2013) Boxun Lu et al.   NATURE NEUROSCIENCE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Proteostasis in complex dendrites

(2013) Cyril Hanus et al.   NATURE REVIEWS NEUROSCIENCE

Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

(2013) Peter E.A. Ash et al.   NEURON

Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases

(2013) Tomohiro Nakamura et al.   NEURON

Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance

(2013) Irina Lonskaya et al.   PLoS One

Lysine 63-linked polyubiquitination is required for EGF receptor degradation

(2013) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

(2013) E. S. Vincow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHIP has a protective role against oxidative stress-induced cell death through specific regulation of Endonuclease G

(2013) J S Lee et al.   Cell Death & Disease

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72

(2012) A. Chio et al.   BRAIN

The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions

(2012) Javier Simón-Sánchez et al.   BRAIN

Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72

(2012) Bradley F. Boeve et al.   BRAIN

Polyglutamine neurodegeneration: expanded glutamines enhance native functions

(2012) Harry T Orr   CURRENT OPINION IN GENETICS & DEVELOPMENT

How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia

(2012) Marka van Blitterswijk et al.   CURRENT OPINION IN NEUROLOGY

NUB1 modulation of GSK3β reduces tau aggregation

(2012) Emma Richet et al.   HUMAN MOLECULAR GENETICS

Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin–proteasomal and autophagy systems

(2012) Haiqun Jia et al.   HUMAN MOLECULAR GENETICS

Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

(2012) C. M. Gladding et al.   HUMAN MOLECULAR GENETICS

Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)

(2012) Michaeline L. Hebron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome-dependent Activation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Is Essential for Autophagy Suppression and Muscle Remodeling Following Denervation

(2012) Pham Nguyen Quy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neddylation dysfunction in Alzheimer's disease

(2012) Yuzhi Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proteasome inhibition leads to early loss of synaptic proteins in neuronal culture

(2012) Natasha Bajic et al.   JOURNAL OF NEURAL TRANSMISSION

GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

(2012) Seung Min Shin et al.   NATURE NEUROSCIENCE

E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity

(2012) Amit Mishra et al.   NEUROBIOLOGY OF AGING

Differential Effects of UCHL1 Modulation on Alpha-Synuclein in PD-Like Models of Alpha-Synucleinopathy

(2012) Anna E. Cartier et al.   PLoS One

Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688

(2012) A. El Ayadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin–proteasome pathway and cellular responses to oxidative stress

(2011) Fu Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein

(2011) Emily S. Stieren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation

(2011) Silvia Zucchelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-κB Activation

(2011) Kamyar Hadian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

(2011) Lionel M. Igaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2

(2011) M. P. Lussier et al.   JOURNAL OF NEUROSCIENCE

A Perturbed Ubiquitin Landscape Distinguishes Between Ubiquitin in Trafficking and in Proteolysis

(2011) Inbal Ziv et al.   MOLECULAR & CELLULAR PROTEOMICS

Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP

(2011) K. Matthew Scaglione et al.   MOLECULAR CELL

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

(2011) Peter M. Andersen et al.   Nature Reviews Neurology

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease

(2011) Baris Bingol et al.   NEURON

Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution

(2011) Suzana Herculano-Houzel   PLoS One

cIAP1/2 Are Direct E3 Ligases Conjugating Diverse Types of Ubiquitin Chains to Receptor Interacting Proteins Kinases 1 to 4 (RIP1–4)

(2011) Mathieu J. M. Bertrand et al.   PLoS One

SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function

(2010) Bing Gong et al.   AGING CELL

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

(2010) Qian Huang et al.   APOPTOSIS

RNA-binding E3 ubiquitin ligases: novel players in nucleic acid regulation

(2010) Florencia Cano et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase

(2010) Papia Ghosh et al.   CELL CYCLE

Autophagy and misfolded proteins in neurodegeneration

(2010) Daniel J. Metcalf et al.   EXPERIMENTAL NEUROLOGY

Rac GTPase-activating Protein (Rac GAP) α1-Chimaerin Undergoes Proteasomal Degradation and Is Stabilized by Diacylglycerol Signaling in Neurons

(2010) Jamie R. K. Marland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study

(2010) Hannu Laaksovirta et al.   LANCET NEUROLOGY

Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death

(2010) Tomohiro Nakamura et al.   MOLECULAR CELL

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

GSK3 and p53 - is there a link in Alzheimer's disease?

(2010) Carole J Proctor et al.   Molecular Neurodegeneration

APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

(2010) Amy K Y Fu et al.   NATURE NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Metaplasticity at Single Glutamatergic Synapses

(2010) Ming-Chia Lee et al.   NEURON

Alterations of Hrd1 expression in various encephalic regional neurons in 6-OHDA model of Parkinson's disease

(2010) Jiaming Mei et al.   NEUROSCIENCE LETTERS

PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins

(2010) A. L. Robertson et al.   NUCLEIC ACIDS RESEARCH

Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM3 Ubiquitin Ligase in Rat Hippocampal Neurons

(2010) Albert Y. Hung et al.   PLoS One

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

(2010) Emanuele Buratti et al.   RNA Biology

Autophagy, a guardian against neurodegeneration

(2010) Moisés García-Arencibia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

SnapShot: F Box Proteins I

(2009) Jeffrey R. Skaar et al.   CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Eps15: a multifunctional adaptor protein regulating intracellular trafficking

(2009) Paul MP van Bergen en Henegouwen   Cell Communication and Signaling

The ubiquitin proteasome system and its involvement in cell death pathways

(2009) F Bernassola et al.   CELL DEATH AND DIFFERENTIATION

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

The Lysine 48 and Lysine 63 Ubiquitin Conjugates Are Processed Differently by the 26 S Proteasome

(2009) Andrew D. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing

(2009) Young Eun Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity

(2009) M. Raspe et al.   JOURNAL OF CELL SCIENCE

DUBs at a glance

(2009) K. D. Wilkinson   JOURNAL OF CELL SCIENCE

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

(2009) Hui Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant  -Synuclein

(2009) X.-H. Lu et al.   JOURNAL OF NEUROSCIENCE

Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis

(2009) Jun Sone et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii

(2009) Fan Zhang et al.   MOLECULAR CELL

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

(2009) Dale E. Bredesen   Molecular Neurodegeneration

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

TDP-43A315T mutation in familial motor neuron disease

(2008) Michael A. Gitcho et al.   ANNALS OF NEUROLOGY

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

(2008) Carolina Maestre et al.   EMBO JOURNAL

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis

(2008) Aislinn J. Williams et al.   NEUROBIOLOGY OF DISEASE