- Home
- Publications
- Publication Search
- Publication Details
Title
Splicing repression is a major function of TDP-43 in motor neurons
Authors
Keywords
Amyotrophic lateral sclerosis, Cryptic exon, <em class="EmphasisTypeItalic ">Drosophila</em>, Motor neuron, Mouse, TDP-43
Journal
ACTA NEUROPATHOLOGICA
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-07-22
DOI
10.1007/s00401-019-02042-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
- (2019) Joseph R. Klim et al. NATURE NEUROSCIENCE
- Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
- (2019) Ze’ev Melamed et al. NATURE NEUROSCIENCE
- Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
- (2019) Joy Mitra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
- (2019) Jacob R. Mann et al. NEURON
- Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
- (2019) Fatima Gasset-Rosa et al. NEURON
- Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality
- (2019) Eloise Hudry et al. NEURON
- Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
- (2018) Lin Guo et al. CELL
- TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
- (2018) Matthew A. White et al. NATURE NEUROSCIENCE
- TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
- (2018) Ching-Chieh Chou et al. NATURE NEUROSCIENCE
- HnRNP L represses cryptic exons
- (2018) Sean P. McClory et al. RNA
- Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization
- (2018) Leeanne McGurk et al. MOLECULAR CELL
- Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology
- (2018) Alissa L. Nana et al. ACTA NEUROPATHOLOGICA
- Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing
- (2017) Yuri Uemura et al. GENES TO CELLS
- Tdp-43 cryptic exons are highly variable between cell types
- (2017) Yun Ha Jeong et al. Molecular Neurodegeneration
- Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
- (2017) Lindsay A. Becker et al. NATURE
- Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy
- (2017) Jerry R. Mendell et al. NEW ENGLAND JOURNAL OF MEDICINE
- Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons
- (2017) Pallavi P. Gopal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model
- (2016) Katherine D. LaClair et al. ACTA NEUROPATHOLOGICA
- Timing and significance of pathological features inC9orf72expansion-associated frontotemporal dementia
- (2016) Sarat C. Vatsavayai et al. BRAIN
- TBPH/TDP-43 modulates translation of Drosophila futsch mRNA through an UG-rich sequence within its 5′UTR
- (2016) Maurizio Romano et al. BRAIN RESEARCH
- Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models
- (2016) Qiumin Tan et al. HUMAN MOLECULAR GENETICS
- Decoding ALS: from genes to mechanism
- (2016) J. Paul Taylor et al. NATURE
- Inhibition of nonsense-mediated RNA decay by ER stress
- (2016) Zhelin Li et al. RNA
- PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons
- (2016) Jonathan P. Ling et al. Cell Reports
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS
- (2015) Mercedes Prudencio et al. NATURE NEUROSCIENCE
- C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
- (2015) J. Chew et al. SCIENCE
- TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
- (2015) J. P. Ling et al. SCIENCE
- Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
- (2014) Nael H. Alami et al. NEURON
- Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis
- (2014) C. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
- (2013) Yohei Iguchi et al. BRAIN
- Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
- (2013) Hyung-Jun Kim et al. NATURE GENETICS
- Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43
- (2013) Peter J Lukavsky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Inhibition of TDP-43 Aggregation by Nucleic Acid Binding
- (2013) Yi-Chen Huang et al. PLoS One
- Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth
- (2013) B. Schmid et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted Depletion of TDP-43 Expression in the Spinal Cord Motor Neurons Leads to the Development of Amyotrophic Lateral Sclerosis-like Phenotypes in Mice
- (2012) Lien-Szu Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis
- (2011) Jari Rossi et al. Cell Metabolism
- TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
- (2011) Karli K. McDonald et al. HUMAN MOLECULAR GENETICS
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration
- (2011) Edward B. Lee et al. NATURE REVIEWS NEUROSCIENCE
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- TDP-43 regulates its mRNA levels through a negative feedback loop
- (2010) Youhna M Ayala et al. EMBO JOURNAL
- Neurotoxic effects of TDP-43 overexpression in C. elegans
- (2010) Peter E.A. Ash et al. HUMAN MOLECULAR GENETICS
- Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
- (2010) Y.-F. Xu et al. JOURNAL OF NEUROSCIENCE
- Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN
- (2010) Kevin D Foust et al. NATURE BIOTECHNOLOGY
- Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism
- (2010) P.-M. Chiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
- (2010) X. Shan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
- (2010) Hans Wils et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
- (2009) Fabienne C Fiesel et al. EMBO JOURNAL
- Depletion of TDP-43 affectsDrosophila motoneuronsterminal synapsis and locomotive behavior
- (2009) Fabian Feiguin et al. FEBS LETTERS
- TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis
- (2009) Lien-Szu Wu et al. GENESIS
- TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development
- (2009) Chantelle F. Sephton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
- (2009) Brian D. Freibaum et al. JOURNAL OF PROTEOME RESEARCH
- TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons
- (2009) Iñigo Casafont et al. JOURNAL OF STRUCTURAL BIOLOGY
- Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis
- (2009) Mohammad Salajegheh et al. MUSCLE & NERVE
- TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
- (2008) Edor Kabashi et al. NATURE GENETICS
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now