Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

Cleavage and polyadenylation: Ending the message expands gene regulation

(2017) Jonathan Neve et al.   RNA Biology

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Roar: detecting alternative polyadenylation with standard mRNA sequencing libraries

(2016) Elena Grassi et al.   BMC BIOINFORMATICS

Protein folding alterations in amyotrophic lateral sclerosis

(2016) Sonam Parakh et al.   BRAIN RESEARCH

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System

(2016) Fernando J. Martinez et al.   NEURON

Increased cytoplasmicTARDBPmRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43

(2016) Akihide Koyama et al.   NUCLEIC ACIDS RESEARCH

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

(2016) Katannya Kapeli et al.   Nature Communications

Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome

(2016) Benxia Hu et al.   Scientific Reports

FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis

(2016) Akio Masuda et al.   Wiley Interdisciplinary Reviews-RNA

Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

(2015) Javier H. Jara et al.   CEREBRAL CORTEX

Position-specific binding of FUS to nascent RNA regulates mRNA length

(2015) Akio Masuda et al.   GENES & DEVELOPMENT

Global estimation of the 3′ untranslated region landscape using RNA sequencing

(2015) MinHyeok Kim et al.   METHODS

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

(2015) Mercedes Prudencio et al.   NATURE NEUROSCIENCE

Comparative pathway and network analysis of brain transcriptome changes during adult aging and in Parkinson's disease

(2015) Enrico Glaab et al.   NEUROBIOLOGY OF DISEASE

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

(2014) Oleg Butovsky et al.   ANNALS OF NEUROLOGY

Alternative polyadenylation: less than meets the eye?: Figure 1

(2014) Jonathan Neve et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

(2014) Chioniso P. Masamha et al.   NATURE

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease

(2014) Chris M. Woodard et al.   Cell Reports

An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes

(2014) Gorica Ristic et al.   Frontiers in Molecular Neuroscience

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

Widespread and extensive lengthening of 3' UTRs in the mammalian brain

(2013) P. Miura et al.   GENOME RESEARCH

Alternative polyadenylation and miR-34 family members regulate tau expression

(2013) John R. Dickson et al.   JOURNAL OF NEUROCHEMISTRY

MiR-26b, Upregulated in Alzheimer's Disease, Activates Cell Cycle Entry, Tau-Phosphorylation, and Apoptosis in Postmitotic Neurons

(2013) S. Absalon et al.   JOURNAL OF NEUROSCIENCE

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

(2013) B. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

(2013) Meng-Shan Tan et al.   TRENDS IN MOLECULAR MEDICINE

The involvement of the cerebellum in amyotrophic lateral sclerosis

(2013) Tino Prell et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2

(2012) J. C. Schwartz et al.   GENES & DEVELOPMENT

A quantitative atlas of polyadenylation in five mammals

(2012) Adnan Derti et al.   GENOME RESEARCH

The ubiquitin proteasome system in neurodegenerative diseases: Culprit, accomplice or victim?

(2012) F.J.A. Dennissen et al.   PROGRESS IN NEUROBIOLOGY

Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology

(2012) Herve Rhinn et al.   Nature Communications

Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain

(2012) Boris Rogelj et al.   Scientific Reports

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

(2011) J. R. Tollervey et al.   GENOME RESEARCH

Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data

(2011) Chaolin Zhang et al.   NATURE BIOTECHNOLOGY

Whole Transcriptome Sequencing Reveals Gene Expression and Splicing Differences in Brain Regions Affected by Alzheimer's Disease

(2011) Natalie A. Twine et al.   PLoS One

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease

(2010) D Ciavardelli et al.   Cell Death & Disease

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

(2008) Donny D. Licatalosi et al.   NATURE

Genetic findings in Parkinson’s disease and translation into treatment: a leading role for mitochondria?

(2007) V. Bogaerts et al.   GENES BRAIN AND BEHAVIOR