The Intestine of Drosophila melanogaster: An Emerging Versatile Model System to Study Intestinal Epithelial Homeostasis and Host-Microbial Interactions in Humans

The neuroactive potential of the human gut microbiota in quality of life and depression

(2019) Mireia Valles-Colomer et al.   Nature Microbiology

Methods for the study of innate immunity in Drosophila melanogaster

(2019) Katia Troha et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Inflammation-Modulated Metabolic Reprogramming Is Required for DUOX-Dependent Gut Immunity in Drosophila

(2018) Kyung-Ah Lee et al.   Cell Host & Microbe

Cytosolic and Secreted Peptidoglycan-Degrading Enzymes in Drosophila Respectively Control Local and Systemic Immune Responses to Microbiota

(2018) Bernard Charroux et al.   Cell Host & Microbe

The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism

(2018) Layla Kamareddine et al.   Cell Metabolism

Drosophila Perpetuates Nutritional Mutualism by Promoting the Fitness of Its Intestinal Symbiont Lactobacillus plantarum

(2018) Gilles Storelli et al.   Cell Metabolism

The Influence of Hormonal Fluctuation on Inflammatory Bowel Disease Symptom Severity—A Cross-Sectional Cohort Study

(2018) Vineet S Rolston et al.   INFLAMMATORY BOWEL DISEASES

Commensal pathogen competition impacts host viability

(2018) David Fast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Drosophila melanogaster Gut Microbiota Provisions Thiamine to Its Host

(2018) David R. Sannino et al.   mBio

The effect of gut microbiota elimination in Drosophila melanogaster : A how-to guide for host-microbiota studies

(2018) Chloe Heys et al.   Ecology and Evolution

Drosophila melanogaster establishes a species-specific mutualistic interaction with stable gut-colonizing bacteria

(2018) Inês S. Pais et al.   PLOS BIOLOGY

Immune–metabolic interactions during systemic and enteric infection in Drosophila

(2018) Kyung-Ah Lee et al.   Current Opinion in Insect Science

Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake

(2018) Anne Abot et al.   Frontiers in Endocrinology

Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy

(2018) Francesca Di Cara et al.   MOLECULAR BIOLOGY OF THE CELL

The importance of being persistent: The first true resident gut symbiont in Drosophila

(2018) Dali Ma et al.   PLOS BIOLOGY

The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria

(2018) Olivia Benguettat et al.   PLoS Pathogens

NOD1 and NOD2 in inflammation, immunity and disease

(2018) Tapas Mukherjee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

(2018) Irene Miguel-Aliaga et al.   GENETICS

Peroxisome-Mediated Metabolism Is Required for Immune Response to Microbial Infection

(2017) Francesca Di Cara et al.   IMMUNITY

Lactobacillus plantarum favors the early emergence of fit and fertile adult Drosophila upon chronic undernutrition

(2017) Mélisandre A. Téfit et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans

(2017) Donggi Paik et al.   JOURNAL OF IMMUNOLOGY

Oligopeptide Transporters of the SLC15 Family Are Dispensable for Peptidoglycan Sensing and Transport in Drosophila

(2017) Florence Capo et al.   Journal of Innate Immunity

A Complex Relationship between Immunity and Metabolism in Drosophila Diet-Induced Insulin Resistance

(2017) Laura Palanker Musselman et al.   MOLECULAR AND CELLULAR BIOLOGY

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Drosophila Genotype Influences Commensal Bacterial Levels

(2017) Angela M. Early et al.   PLoS One

Constitutive Immune Activity Promotes Tumorigenesis in Drosophila Intestinal Progenitor Cells

(2017) Kristina Petkau et al.   Cell Reports

Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior

(2017) Caleb N Fischer et al.   eLife

Drosophila melanogaster as a High-Throughput Model for Host–Microbiota Interactions

(2017) Mark Trinder et al.   Frontiers in Microbiology

Physiology of Intestinal Absorption and Secretion

(2016) Pawel R. Kiela et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology

(2016) Felix Sommer et al.   BIOESSAYS

Molecular and cellular studies on the absorption, function, and safety of food components in intestinal epithelial cells

(2016) Hideo Satsu   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The Drosophila transcriptional network is structured by microbiota

(2016) Adam J. Dobson et al.   BMC GENOMICS

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan

(2016) Hongjie Li et al.   Cell Host & Microbe

Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack

(2016) Kwang-Zin Lee et al.   Cell Host & Microbe

Bacteria sensing mechanisms in Drosophila gut: Local and systemic consequences

(2016) Florence Capo et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

From pathogens to microbiota: How Drosophila intestinal stem cells react to gut microbes

(2016) Alessandro Bonfini et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The interplay between intestinal bacteria and host metabolism in health and disease: lessons fromDrosophila melanogaster

(2016) Adam C. N. Wong et al.   Disease Models & Mechanisms

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

(2016) Claudine Neyen et al.   NATURE IMMUNOLOGY

Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries

(2016) Ai Tian et al.   PLoS Genetics

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

(2016) Sveta Chakrabarti et al.   PLoS Genetics

Glucose modulatesDrosophilalongevity and immunity independent of the microbiota

(2016) Anthony Galenza et al.   Biology Open

Rearing the Fruit Fly Drosophila melanogaster Under Axenic and Gnotobiotic Conditions

(2016) Melinda L. Koyle et al.   Jove-Journal of Visualized Experiments

Molecular mechanism and functional significance of acid generation in the Drosophila midgut

(2016) Gayle Overend et al.   Scientific Reports

Bacterial Uracil Modulates Drosophila DUOX-Dependent Gut Immunity via Hedgehog-Induced Signaling Endosomes

(2015) Kyung-Ah Lee et al.   Cell Host & Microbe

Control of Brain Development, Function, and Behavior by the Microbiome

(2015) Timothy R. Sampson et al.   Cell Host & Microbe

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota

(2015) C. T. Peterson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Diversity of animal immune receptors and the origins of recognition complexity in the deuterostomes

(2015) Katherine M. Buckley et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens

(2015) Roshan K. Vijendravarma et al.   ECOLOGY LETTERS

Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine

(2015) Helmut Grasberger et al.   GASTROENTEROLOGY

Insulin/IGF signaling and its regulation in Drosophila

(2015) Dick R. Nässel et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

All for one and one for all: Regionalization of the Drosophila intestine

(2015) Nicolas Buchon et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system

(2015) Panagiotis S. Kabouridis et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-Specific Regulation of Drosophila NF-κB Pathway Activation by Peptidoglycan Recognition Protein SC

(2015) Denis Costechareyre et al.   Journal of Innate Immunity

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Niche appropriation by Drosophila intestinal stem cell tumours

(2015) Parthive H. Patel et al.   NATURE CELL BIOLOGY

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

(2015) Z. Guo et al.   SCIENCE

Sex-based differences in immune function and responses to vaccination

(2015) S. L. Klein et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

(2015) Rebecca I. Clark et al.   Cell Reports

Molecular mechanisms for the evolution of bacterial morphologies and growth modes

(2015) Amelia M. Randich et al.   Frontiers in Microbiology

Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk

(2015) Luca Miele et al.   Current Cardiology Reports

How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology

(2015) Simona Frosali et al.   Journal of Immunology Research

Do Antimicrobial Peptides and Complement Collaborate in the Intestinal Mucosa?

(2015) Zoë A. Kopp et al.   Frontiers in Immunology

The Medium Is the Message: Interspecies and Interkingdom Signaling by Peptidoglycan and Related Bacterial Glycans

(2014) Jonathan Dworkin   Annual Review of Microbiology

The Acetate Switch of an Intestinal Pathogen Disrupts Host Insulin Signaling and Lipid Metabolism

(2014) Saiyu Hang et al.   Cell Host & Microbe

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

(2014) Irfan J. Lodhi et al.   Cell Metabolism

The biology of bacterial peptidoglycans and their impact on host immunity and physiology

(2014) Richard Wheeler et al.   CELLULAR MICROBIOLOGY

Homeostasis between gut-associated microorganisms and the immune system in Drosophila

(2014) Hyejin You et al.   CURRENT OPINION IN IMMUNOLOGY

The Drosophila Imd Signaling Pathway

(2014) H. Myllymaki et al.   JOURNAL OF IMMUNOLOGY

Methods to study Drosophila immunity

(2014) Claudine Neyen et al.   METHODS

Bacterial Peptidoglycan Stimulates Adipocyte Lipolysis via NOD1

(2014) Wendy Chi et al.   PLoS One

Metagenome-Wide Association of Microbial Determinants of Host Phenotype in Drosophila melanogaster

(2014) J. M. Chaston et al.   mBio

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

(2014) N. A. Broderick et al.   mBio

Human pathogenic bacteria, fungi, and viruses inDrosophila

(2014) Stavria Panayidou et al.   Virulence

Role of DUOX in gut inflammation: lessons from Drosophila model of gut-microbiota interactions

(2014) Sung-Hee Kim et al.   Frontiers in Cellular and Infection Microbiology

The bacterial communities ofDrosophila suzukiicollected from undamaged cherries

(2014) James Angus Chandler et al.   PeerJ

The Digestive Tract ofDrosophila melanogaster

(2013) Bruno Lemaitre et al.   Annual Review of Genetics

Bacterial-Derived Uracil as a Modulator of Mucosal Immunity and Gut-Microbe Homeostasis in Drosophila

(2013) Kyung-Ah Lee et al.   CELL

Host-Intestinal Microbiota Mutualism: “Learning on the Fly”

(2013) Berra Erkosar et al.   Cell Host & Microbe

Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxide Release

(2013) William Razzell et al.   CURRENT BIOLOGY

The Drosophila IMD pathway in the activation of the humoral immune response

(2013) Anni Kleino et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The inconstant gut microbiota of Drosophila species revealed by 16S rRNA gene analysis

(2013) Adam C-N Wong et al.   ISME Journal

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Gut homeostasis in a microbial world: insights from Drosophila melanogaster

(2013) Nicolas Buchon et al.   NATURE REVIEWS MICROBIOLOGY

Host Species and Environmental Effects on Bacterial Communities Associated with Drosophila in the Laboratory and in the Natural Environment

(2013) Fabian Staubach et al.   PLoS One

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Frequent Replenishment Sustains the Beneficial Microbiome of Drosophila melanogaster

(2013) J. E. Blum et al.   mBio

Bacterial cell-wall recycling

(2012) Jarrod W. Johnson et al.   Annals of the New York Academy of Sciences

THIOCYANATE: A potentially useful therapeutic agent with host defense and antioxidant properties

(2012) Joshua D. Chandler et al.   BIOCHEMICAL PHARMACOLOGY

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

Peptidoglycan Sensing by the Receptor PGRP-LE in the Drosophila Gut Induces Immune Responses to Infectious Bacteria and Tolerance to Microbiota

(2012) Virginie Bosco-Drayon et al.   Cell Host & Microbe

Intestinal stem cell function in Drosophila and mice

(2012) Huaqi Jiang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The complementary facets of epithelial host defenses in the genetic model organism Drosophila melanogaster: from resistance to resilience

(2012) Dominique Ferrandon   CURRENT OPINION IN IMMUNOLOGY

Stem cells and lineages of the intestine: a developmental and evolutionary perspective

(2012) Shigeo Takashima et al.   DEVELOPMENT GENES AND EVOLUTION

Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota

(2012) Michael Graham Espey   FREE RADICAL BIOLOGY AND MEDICINE

Is there a gender difference in the prevalence of Crohnʼs disease or ulcerative colitis?

(2012) Steven R. Brant et al.   INFLAMMATORY BOWEL DISEASES

Bacteria, Colonic Fermentation, and Gastrointestinal Health

(2012) George T. Macfarlane et al.   JOURNAL OF AOAC INTERNATIONAL

Tissue- and Ligand-Specific Sensing of Gram-Negative Infection in Drosophila by PGRP-LC Isoforms and PGRP-LE

(2012) C. Neyen et al.   JOURNAL OF IMMUNOLOGY

The Pyrimidine Nucleotide Biosynthetic Pathway Modulates Production of Biofilm Determinants in Escherichia coli

(2012) Marco Garavaglia et al.   PLoS One

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth

(2011) Lucy Erin O'Brien et al.   CELL

Dietary Restriction and Aging: A Unifying Perspective

(2011) Matthew D.W. Piper et al.   Cell Metabolism

Composition and functional role of the mucus layers in the intestine

(2011) Malin E. V. Johansson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Low-diversity bacterial community in the gut of the fruitfly Drosophila melanogaster

(2011) Chun Nin Adam Wong et al.   ENVIRONMENTAL MICROBIOLOGY

Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers

(2011) Bryan D. White et al.   GASTROENTEROLOGY

Peptidomics and Peptide Hormone Processing in theDrosophilaMidgut

(2011) Wencke Reiher et al.   JOURNAL OF PROTEOME RESEARCH

Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

(2011) T. Kuraishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

(2011) S. C. Shin et al.   SCIENCE

Bacterial Communities of Diverse Drosophila Species: Ecological Context of a Host–Microbe Model System

(2011) James Angus Chandler et al.   PLoS Genetics

Drosophila melanogaster as an Animal Model for the Study of Pseudomonas aeruginosa Biofilm Infections In Vivo

(2011) Heidi Mulcahy et al.   PLoS Pathogens

Nutritional Immunology: A Multi-Dimensional Approach

(2011) Fleur Ponton et al.   PLoS Pathogens

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Dual oxidase in mucosal immunity and host–microbe homeostasis

(2010) Yun Soo Bae et al.   TRENDS IN IMMUNOLOGY

Regulation of DUOX by the Gαq-Phospholipase Cβ-Ca2+ Pathway in Drosophila Gut Immunity

(2009) Eun-Mi Ha et al.   DEVELOPMENTAL CELL

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Epithelial ultrastructure and cellular mechanisms of acid and base transport in the Drosophila midgut

(2009) S. Shanbhag et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Mucosal immunity: aliment and ailments

(2009) E Raz   Mucosal Immunology

Coordination of multiple dual oxidase–regulatory pathways in responses to commensal and infectious microbes in drosophila gut

(2009) Eun-Mi Ha et al.   NATURE IMMUNOLOGY

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

(2009) N. Buchon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia

(2009) Y. Apidianakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

(2009) J. R. DiAngelo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Insights into Peritrophic Matrix Synthesis, Architecture, and Function

(2008) Dwayne Hegedus et al.   Annual Review of Entomology

Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process

(2008) Su Duy Nguyen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Autophagic control of listeria through intracellular innate immune recognition in drosophila

(2008) Tamaki Yano et al.   NATURE IMMUNOLOGY

A Potential Role for Drosophila Mucins in Development and Physiology

(2008) Zulfeqhar A. Syed et al.   PLoS One

Discerning the Complexity of Community Interactions Using a Drosophila Model of Polymicrobial Infections

(2008) Christopher D. Sibley et al.   PLoS Pathogens