Review
Immunology
Charneal L. Dixon, Amy Wu, Gregory D. Fairn
Summary: This article summarizes the receptor functions of nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and NOD2, which can recognize peptides derived from bacterial cell wall components. In addition, the dynamic regulation of NOD and its impact on immune responses are described in detail. Finally, the importance of NOD in the pathogenesis of inflammatory diseases is discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Lokender Kumar, Nathanael M. Brenner, Samuel Sledzieski, Monsurat Olaosebikan, Liza Roger, Matthew Lynn-Goin, Roshan Klein-Seetharaman, Bonnie A. Berger, Hollie Putnam, Jinkyu M. Yang, Nastassja A. Lewinski, Rohit Singh, Noah M. Daniels, Lenore Cowen, Judith Klein-Seetharaman
Summary: With the advancement of technology, it has become urgent to develop new methods to understand non-model organisms based on the knowledge gained from model organisms.
Article
Fisheries
Jing Hou, Zhen Gan, Shannan Chen, Jun Cheng, Yishan Lu, Bei Huang, Pin Nie, Liqun Xia
Summary: A novel short-type PGRP gene named Eco-PGRP-S was identified in the orange-spotted grouper, showing inducible expression and antibacterial activity against Vibrio Harveri and Edwardsiella tarda. Eco-PGRP-S plays a significant role in activating NF-kappa B signaling pathway.
AQUACULTURE REPORTS
(2021)
Article
Immunology
Layale Salem Wehbe, Dana Barakat, Adrian Acker, Rita El Khoury, Jean-Marc Reichhart, Nicolas Matt, Laure El Chamy
Summary: The study identified the highly conserved protein phosphatase 4 (PP4) complex as a negative regulator of the IMD pathway, ensuring tight regulation of immune response to prevent harmful effects. Depletion of PP4 in fruit flies leads to reduced lifespan and increased sensitivity to bacterial infections, highlighting the evolutionarily conserved role of PP4 in regulating NF-kappa B signaling from Drosophila to mammals.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chihyun Won, Kyungju Nam, Donghee Ko, Byungjun Kang, Im-Soon Lee
Summary: The inactivation of nuclear receptor-binding SET domain-containing protein 1 (NSD1) in tumor cells contributes to an immune-cold phenotype, suggesting its involvement in immune disruptions. The study investigates the effect of NSD overexpression in the fat body of Drosophila and finds that it increases the mRNA levels of antimicrobial peptides, mainly through the IMD pathway by activating Relish. Further analysis shows that NSD overexpression has a positive role in the immune defenses of Drosophila. These findings provide insights into the molecular mechanisms of immune dysfunction in NSD1-associated human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ambra Masuzzo, Gerard Maniere, Yael Grosjean, Leopold Kurz, Julien Royet
Summary: Probing the external world is crucial for eukaryotes to distinguish beneficial from pathogenic micro-organisms. Recent research reveals that neurons, in addition to immune cells, can detect microbes, although the specific molecules and mechanisms involved are not well understood. In this study, the authors demonstrate that a peptidoglycan recognition protein (PGRP) called PGRPLB is expressed in bitter gustatory neurons of fruit flies. They show that the PGRP/IMD pathway in these neurons is necessary to transduce the peptidoglycan signal, and its activation influences fly behavior. This highlights the importance of an immune response and signaling module in the peripheral nervous system for sensing bacteria in the environment.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Anna L. Aalto, Atefeh Saadabadi, Fanny Lindholm, Christa Kietz, Emmy Himmelroos, Parthiban Marimuthu, Outi M. H. Salo-Ahen, Patrik Eklund, Annika Meinander
Summary: This study demonstrates the anti-inflammatory properties of stilbenoid compounds PS and PSMME in the intestine of fruit flies, and their potential to alleviate chemically induced intestinal inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Rebecca Louise Brown, Max Louis Yeung Larkinson, Thomas Brian Clarke
Summary: Our study systematically profiles the immunological impact of major human commensal species and paves the way for rational microbiota reengineering to protect against antibiotic resistant infections and to treat intestinal inflammation. The unique complement of pattern recognition receptors, intracellular signaling components and transcription factors engaged by different commensal species were identified to guide the construction of therapeutic symbiont communities. Canonical NF-kappa B signaling acts as a critical rheostat which grades the degree of immune stimulation commensals elicit.
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Review
Fisheries
Juliette Schneider, Jean-Luc Imler
Summary: The fruitfly Drosophila melanogaster is a valuable model for studying innate immune mechanisms, especially in the context of viral infections. Research has uncovered the importance of RNA interference and inducible transcriptional responses in antiviral immunity in fruitflies. Recent discoveries of signaling pathways in fruitflies, such as the STING-IKK beta-Relish cassette, highlight the role of NF-kappa B transcription factors in controlling viral infections, in addition to bacterial and fungal infections.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hana Lee, Donghyun Hwang, Minjoo Lee, Jinho Lee, Seungkwan Cho, Tack-Joong Kim, Han Sung Kim
Summary: This study investigated the anti-inflammatory effect of micro-current stimulation on macrophages and skin inflammation caused by P. acnes. The results showed that micro-current stimulation can decrease the expression of proteins related to TLR2/NF-kappa B signaling and reduce the area of acne lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yuchen Chen, Wenhao Xu, Yuan Chen, Anxuan Han, Jiantao Song, Xiaoya Zhou, Wei Song
Summary: This study reveals a fundamental mechanism linking gut commensal dysbiosis, renal immune activation, and uric acid imbalance in tumor-associated host death. Flies with malignant gut tumors showed an exponential increase in commensal bacteria and systemic immune activation, leading to suppression of a gut antibacterial enzyme. Eliminating gut microbiota or blocking specific immune activation pathways dramatically improved the survival of tumor-bearing flies, independent of host wasting.
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Ye Yuan, Max Van Belkum, Alana O'Brien, Alain Garcia, Karla Troncoso, Ahmed S. Elshikha, Lei Zhou, Sihong Song
Summary: In this study, the antiaging effect of human alpha 1 antitrypsin (hAAT) was explored. The results showed that hAAT treatment selectively inhibited NF-kappa B-targeted genes and pathways in human senescent cells. Further experiments using Drosophila models demonstrated that hAAT had positive effects on locomotor activity and lifespan. These findings enhance our understanding of the anti-inflammatory function of hAAT.
Article
Medicine, Research & Experimental
Marion Seillier, Laurent Pouyet, Prudence N'Guessan, Marie Nollet, Florence Capo, Fabienne Guillaumond, Laure Peyta, Jean-Francois Dumas, Annie Varrault, Gyslaine Bertrand, Stephanie Bonnafous, Albert Tran, Gargi Meur, Piero Marchetti, Magalie A. Ravier, Stephane Dalle, Philippe Gual, Dany Muller, Guy A. Rutter, Stephane Servais, Juan L. Iovanna, Alice Carrier
EMBO MOLECULAR MEDICINE
(2015)
Article
Immunology
Denis Costechareyre, Florence Capo, Alexandre Fabre, Delphine Chaduli, Christine Kellenberger, Alain Roussel, Bernard Charroux, Julien Royet
JOURNAL OF INNATE IMMUNITY
(2016)
Article
Fisheries
Florence Capo, Bernard Charroux, Julien Royet
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2016)
Article
Microbiology
Bernard Charroux, Florence Capo, C. Leopold Kurz, Sabine Peslier, Delphine Chaduli, Annelise Viallat-lieutaud, Julien Royet
CELL HOST & MICROBE
(2018)
Review
Microbiology
Florence Capo, Alexa Wilson, Francesca Di Cara