Article
Immunology
Amanda D. Caulfield, Maiya Callender, Eric T. Harvill
Summary: Bordetella pertussis is the causative agent of whooping cough, a severe respiratory disease with high morbidity and mortality in infants and young children. Current vaccines do not provide long-lasting immunity and cannot prevent subclinical infection or transmission. Research limitations and potent immunomodulation by the bacterium have hindered efforts to generate robust mucosal immunity. New directions and methods are needed to fill critical gaps in understanding host-pathogen dynamics and to develop novel vaccines that can halt the circulation of Bordetella pertussis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Devaki Pilapitiya, Adam K. Wheatley, Hyon-Xhi Tan
Summary: Currently approved COVID-19 vaccines administered parenterally induce robust systemic humoral and cellular responses, but their effectiveness in preventing breakthrough infection and/or transmission is limited due to poor immunity at the respiratory mucosa. Therefore, there is considerable interest in developing mucosal vaccines that elicit localized immune responses for better protection at the site of virus entry. This review explores mucosal immunity, evaluates studies on the efficacy of mucosal immunity conferred by vaccination or respiratory infection, discusses ongoing clinical trials of mucosal vaccines, and assesses challenges and prospects for mucosal vaccine development.
Article
Nanoscience & Nanotechnology
Sachin S. Surwase, S. M. Shatil Shahriar, Jeong Man An, JongHoon Ha, Amin Mirzaaghasi, Babak Bagheri, Ji-ho Park, Yong-kyu Lee, Yeu-Chun Kim
Summary: This study designed a novel tandem peptide to target FAE, including M-cells and enterocytes, instead of M-cell targeting. The results showed a significant induction of both mucosal and systemic immune responses, making a significant breakthrough compared to previous M-cell targeting research.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nutrition & Dietetics
Noah Joseph Murr, Tyler B. Olender, Margaret R. Smith, Amari S. Smith, Jennifer Pilotos, Lyndsay B. Richard, Chishimba Nathan Mowa, Michael Makokha Opata
Summary: The study revealed that moderately malnourished mice infected with malaria had lower parasite burden at the peak of infection, but showed damaged mucosal epithelial cells, increased intestinal permeability, shortened small intestine, and decreased number of innate immune cells in the large intestine. Despite lower numbers, macrophages in the moderately malnourished mice were highly activated in the small intestine, indicating exacerbation of some abnormalities in the gut induced by the moderate malnutrition.
Article
Medicine, Research & Experimental
Kevin J. Selva, Pradhipa Ramanathan, Ebene R. Haycroft, Arnold Reynaldi, Deborah Cromer, Chee Wah Tan, Lin-Fa Wang, Bruce D. Wines, P. Mark Hogarth, Laura E. Downie, Samantha K. Davis, Ruth A. Purcell, Helen E. Kent, Jennifer A. Juno, Adam K. Wheatley, Miles P. Davenport, Stephen J. Kent, Amy W. Chung
Summary: Understanding the immune response of mucosal antibodies in SARS-CoV-2 infection and vaccination is crucial for long-term immunity. COVID-19-recovered vaccinees showed improved antibody-neutralizing activity, Fc gamma receptor engagement, and IgA levels in saliva compared to vaccinated, uninfected individuals. Repeated mRNA vaccination boosted SARS-CoV-2-specific IgG2 and IgG4 responses in mucosal biofluids and plasma, with a negative correlation with Fc gamma receptor engagement in plasma. Breakthrough COVID-19 variants showed dampened IgG and Fc gamma receptor engagement responses, but not IgA, due to preexisting vaccine-induced immunity against the ancestral strain.
Review
Immunology
Qiao Liu, Xia Niu, Yang Li, Jia-rui Zhang, Shao-jun Zhu, Qi-yuan Yang, Wei Zhang, Li Gong
Summary: IgGFc-binding protein (FCGBP) plays an important role in immune responses and disease development, particularly in tumor prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Valeria Caputo, Martina Libera, Sofia Sisti, Benedetta Giuliani, Roberta A. Diotti, Elena Criscuolo
Summary: Human Immunodeficiency Virus (HIV) remains a major global health issue, and the mucosal innate immune response and microbiota play crucial roles in HIV infection. The mucosae act as a physical barrier that can be compromised by the virus, leading to innate immune response, and the mucosal microbiota can influence the development of opportunistic infections. However, a proper characterization of mucosal innate immune response and microbiota is still lacking, and further studies are needed to understand their potential in vaccine development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Duo Fu, Mengjia Wang, Tao Yang, Min Li, Zhihui Liang, Chen Chen, Lei Zhang, Changying Xue, Bingbing Sun, Chuanbin Mao
Summary: This study investigated the interaction between nanofibers and the mucosal interface, as well as the impact of nanofiber length on immune responses. The results showed that shorter nanofibers had a stronger ability to activate immune responses and enhance mucosal and systematic antibody responses. Additionally, vaccines adjuvanted with shorter nanofibers were able to induce cytotoxic T lymphocyte responses, effectively inhibiting tumor growth.
Review
Immunology
Lindsay M. Snyder, Eric Y. Denkers
Summary: The gastrointestinal tract serves as a major entry point for pathogens, including Toxoplasma gondii. Host defense against Toxoplasma is primarily located in the intestinal mucosa, involving a coordinated response from epithelial cells, intraepithelial lymphocytes, and lamina propria cells. Infections may lead to bacterial dysbiosis and immune-mediated tissue damage in the intestine, highlighting the complex interactions between microbiota, epithelium, and immune cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kaori Sano, Disha Bhavsar, Gagandeep Singh, Daniel Floda, Komal Srivastava, Charles Gleason, Juan Manuel Carreno, Viviana Simon, Florian Krammer
Summary: This study reveals that prior SARS-CoV-2 infection enhances the induction of mucosal SARS-CoV-2 secretory IgA antibody following mRNA vaccination, while individuals without prior exposure to the virus have a minimal mucosal antibody response.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Peter F. Wright, Alejandra C. Prevost-Reilly, Harini Natarajan, Elizabeth B. Brickley, Ruth Connor, Wendy F. Wieland-Alter, Anna S. Miele, Joshua A. Weiner, Robert D. Nerenz, Margaret E. Ackerman
Summary: Respiratory/mucosal and serum/systemic antibody responses to SARS-CoV-2 infection are distinct host defense mechanisms influenced by age, severity of illness, and immunoglobulin class. Stimulation of respiratory immunity is crucial for SARS-CoV-2 vaccines aiming to limit transmission.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Yuchun Xu, Xiaoying Yan, Ting Wei, Minming Chen, Jiafei Zhu, Juxin Gao, Bo Liu, Wenjun Zhu, Zhuang Liu
Summary: Intranasal vaccines can induce immune responses at mucosa surface entrance to prevent respiratory pathogens invasion. Researchers have developed a transmucosal nanovaccine based on modified chitosan to induce mucosal immunity.
Article
Respiratory System
Ruben Cornelis Anthonie de Groot, Silvia Cristina Estevao, Patrick Michael Meyer Sauteur, Aditya Perkasa, Theo Hoogenboezem, Emiel Benny Margriet Spuesens, Lilly Maria Verhagen, Anna Maria Christiane van Rossum, Wendy Wilhelmina Josephina Unger
Summary: Mycoplasma pneumoniae-specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells, and are induced only during M. pneumoniae infection and not during asymptomatic carriage.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Instruments & Instrumentation
Li Qin, Yanhua Sun, Nan Gao, Guixia Ling, Peng Zhang
Summary: Vaccines are crucial for global health, and inhalable vaccines offer unique advantages. Understanding advanced delivery technologies for inhalable vaccines is essential for development. This review article provides a detailed description of immune mechanisms, preparation methods, and advanced nanotechnologies for inhalable vaccines. The latest clinical progress in inhalable vaccines for COVID-19 and tuberculosis is also discussed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)