The interplay between intestinal bacteria and host metabolism in health and disease: lessons fromDrosophila melanogaster

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Bacterial Uracil Modulates Drosophila DUOX-Dependent Gut Immunity via Hedgehog-Induced Signaling Endosomes

(2015) Kyung-Ah Lee et al.   Cell Host & Microbe

Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion

(2015) Berra Erkosar et al.   Cell Host & Microbe

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

(2015) Siegfried Ussar et al.   Cell Metabolism

Collateral damage from oral ciprofloxacin versus nitrofurantoin in outpatients with urinary tract infections: a culture-free analysis of gut microbiota

(2015) A.J. Stewardson et al.   CLINICAL MICROBIOLOGY AND INFECTION

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting

(2015) Alejandra Figueroa-Clarevega et al.   DEVELOPMENTAL CELL

Systemic Organ Wasting Induced by Localized Expression of the Secreted Insulin/IGF Antagonist ImpL2

(2015) Young Kwon et al.   DEVELOPMENTAL CELL

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Insulin/IGF signaling and its regulation in Drosophila

(2015) Dick R. Nässel et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Keeping bugs in check: The mucus layer as a critical component in maintaining intestinal homeostasis

(2015) Martin Faderl et al.   IUBMB LIFE

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Hepatitis C virus and lipid droplets: finding a niche

(2015) Ana Filipe et al.   TRENDS IN MOLECULAR MEDICINE

A Molecular-Level Landscape of Diet-Gut Microbiome Interactions: Toward Dietary Interventions Targeting Bacterial Genes

(2015) Yueqiong Ni et al.   mBio

Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster

(2015) Adam J. Dobson et al.   Nature Communications

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

(2015) Yael R. Nobel et al.   Nature Communications

Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation

(2015) Mayu Kasubuchi et al.   Nutrients

Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies

(2015) Russell J de Souza et al.   BMJ-British Medical Journal

Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut

(2015) Devanjali Dutta et al.   Cell Reports

Drosophila Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake

(2015) Míriam Rodríguez-Vázquez et al.   PLoS Genetics

Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins

(2015) Toshio Shibata et al.   PLoS Pathogens

Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies

(2015) Russell J de Souza et al.   BMJ-British Medical Journal

Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk

(2015) Luca Miele et al.   Current Cardiology Reports

Mucin glycan foraging in the human gut microbiome

(2015) Louise E. Tailford et al.   Frontiers in Genetics

Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children

(2015) Chenhong Zhang et al.   EBioMedicine

Differential Effects of Tissue-Specific Deletion of BOSS on Feeding Behaviors and Energy Metabolism

(2015) Ayako Kohyama-Koganeya et al.   PLoS One

An evolving perspective about the origins of childhood undernutrition and nutritional interventions that includes the gut microbiome

(2014) Tahmeed Ahmed et al.   Annals of the New York Academy of Sciences

EFFECTS OF DIURETIC HORMONE 31, DROSOKININ, AND ALLATOSTATIN A ON TRANSEPITHELIAL K+TRANSPORT AND CONTRACTION FREQUENCY IN THE MIDGUT AND HINDGUT OF LARVALDrosophila melanogaster

(2014) Mark Vanderveken et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Role of free fatty acid receptors in the regulation of energy metabolism

(2014) Takafumi Hara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage

(2014) Christine Moessinger et al.   BMC CELL BIOLOGY

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

(2014) Laura M. Cox et al.   CELL

The Acetate Switch of an Intestinal Pathogen Disrupts Host Insulin Signaling and Lipid Metabolism

(2014) Saiyu Hang et al.   Cell Host & Microbe

Managing the manager: Gut microbes, stem cells and metabolism

(2014) M. Serino et al.   DIABETES & METABOLISM

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Gut microbiota dictates the metabolic response of Drosophila to diet

(2014) A. C.- N. Wong et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Gut Microbiome and the Brain

(2014) Leo Galland   JOURNAL OF MEDICINAL FOOD

Persistent gut microbiota immaturity in malnourished Bangladeshi children

(2014) Sathish Subramanian et al.   NATURE

FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations

(2014) G. dos Santos et al.   NUCLEIC ACIDS RESEARCH

Nutrient regulation of glucagon secretion: involvement in metabolism and diabetes

(2014) Laura Marroquí et al.   NUTRITION RESEARCH REVIEWS

Childhood malnutrition and the intestinal microbiome

(2014) Anne V. Kane et al.   PEDIATRIC RESEARCH

Gut microbiota and GLP-1

(2014) Amandine Everard et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Drosophila gains traction as a repurposed tool to investigate metabolism

(2014) Divya Padmanabha et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genetic Susceptibility to Type 2 Diabetes and Obesity: Follow-Up of Findings from Genome-Wide Association Studies

(2014) Kevin J. Basile et al.   International Journal of Endocrinology

Control of Lipid Metabolism by Tachykinin in Drosophila

(2014) Wei Song et al.   Cell Reports

Free fatty acid receptors as therapeutic targets for the treatment of diabetes

(2014) Atsuhiko Ichimura et al.   Frontiers in Pharmacology

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Interspecies Interactions Determine the Impact of the Gut Microbiota on Nutrient Allocation in Drosophila melanogaster

(2013) Peter D. Newell et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

From fatty-acid sensing to chylomicron synthesis: Role of intestinal lipid-binding proteins

(2013) Marjorie Buttet et al.   BIOCHIMIE

Bacterial-Derived Uracil as a Modulator of Mucosal Immunity and Gut-Microbe Homeostasis in Drosophila

(2013) Kyung-Ah Lee et al.   CELL

An Ecological Network of Polysaccharide Utilization among Human Intestinal Symbionts

(2013) Seth Rakoff-Nahoum et al.   CURRENT BIOLOGY

Gut microbiota, enteroendocrine functions and metabolism

(2013) Patrice D Cani et al.   CURRENT OPINION IN PHARMACOLOGY

Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions

(2013) Ladan Sarraf-Zadeh et al.   DEVELOPMENTAL BIOLOGY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Rapid evolution of the human gut virome

(2013) S. Minot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERK signaling couples nutrient status to antiviral defense in the insect gut

(2013) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

(2013) M. I. Smith et al.   SCIENCE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Frequent Replenishment Sustains the Beneficial Microbiome of Drosophila melanogaster

(2013) J. E. Blum et al.   mBio

Metagenomic profile of gut microbiota in children during cholera and recovery

(2013) Shirajum Monira et al.   Gut Pathogens

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

(2013) Nicolas Buchon et al.   Cell Reports

Physiological and stem cell compartmentalization within the Drosophila midgut

(2013) Alexis Marianes et al.   eLife

Factors that regulate insulin producing cells and their output in Drosophila

(2013) Dick R. Nässel et al.   Frontiers in Physiology

High-Throughput Sequencing Reveals the Incomplete, Short-Term Recovery of Infant Gut Microbiota following Parenteral Antibiotic Treatment with Ampicillin and Gentamicin

(2012) Fiona Fouhy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcriptional Pausing Controls a Rapid Antiviral Innate Immune Response in Drosophila

(2012) Jie Xu et al.   Cell Host & Microbe

Infection-Induced Host Translational Blockage Inhibits Immune Responses and Epithelial Renewal in the Drosophila Gut

(2012) Sveta Chakrabarti et al.   Cell Host & Microbe

Gut microbiota correlates with energy gain from dietary fibre and appears to be associated with acute and chronic intestinal diseases

(2012) M. Ukhanova et al.   CLINICAL MICROBIOLOGY AND INFECTION

Unique roles of glucagon and glucagon-like peptides: Parallels in understanding the functions of adipokinetic hormones in stress responses in insects

(2012) Andrea Bednářová et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

New Insights into the Pathogenesis of Tuberculosis Revealed by Mycobacterium marinum: The Zebrafish Model from the Systems Biology Perspective

(2012) Wanyan Deng et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Gastrointestinal chemosensation: chemosensory cells in the alimentary tract

(2012) H. Breer et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The apical plasma membrane of chitin-synthesizing epithelia

(2012) Bernard Moussian   Insect Science

The gut microbiota, obesity and insulin resistance

(2012) Jian Shen et al.   MOLECULAR ASPECTS OF MEDICINE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

The human microbiome: ecosystem resilience and health

(2012) David A Relman   NUTRITION REVIEWS

Impact of the Resident Microbiota on the Nutritional Phenotype of Drosophila melanogaster

(2012) Emma V. Ridley et al.   PLoS One

Listeria monocytogenes Infection Causes Metabolic Shifts in Drosophila melanogaster

(2012) Moria C. Chambers et al.   PLoS One

Diet: Friend or Foe of Enteroendocrine Cells: How It Interacts with Enteroendocrine Cells

(2012) Sofia Moran-Ramos et al.   Advances in Nutrition

Lipoproteins in Drosophila melanogaster—Assembly, Function, and Influence on Tissue Lipid Composition

(2012) Wilhelm Palm et al.   PLoS Genetics

Emerging Roles for Lipid Droplets in Immunity and Host-Pathogen Interactions

(2011) Hector Alex Saka et al.   Annual Review of Cell and Developmental Biology

Lactobacillus plantarum Promotes Drosophila Systemic Growth by Modulating Hormonal Signals through TOR-Dependent Nutrient Sensing

(2011) Gilles Storelli et al.   Cell Metabolism

Coordination of Triacylglycerol and Cholesterol Homeostasis by DHR96 and the Drosophila LipA Homolog magro

(2011) Matthew H. Sieber et al.   Cell Metabolism

Enteroendocrine cells and lipid absorption

(2011) Georg Mellitzer et al.   CURRENT OPINION IN LIPIDOLOGY

Low-diversity bacterial community in the gut of the fruitfly Drosophila melanogaster

(2011) Chun Nin Adam Wong et al.   ENVIRONMENTAL MICROBIOLOGY

A genome-scale shRNA resource for transgenic RNAi in Drosophila

(2011) Jian-Quan Ni et al.   NATURE METHODS

Heterogeneous Expression of Drosophila Gustatory Receptors in Enteroendocrine Cells

(2011) Jeong-Ho Park et al.   PLoS One

Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

(2011) T. Kuraishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially selective colonization of the arthropod intestine through activation of Vibrio cholerae biofilm formation

(2011) A. E. Purdy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

(2011) S. C. Shin et al.   SCIENCE

Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing

(2011) Catia Sternini et al.   Current Opinion in Endocrinology Diabetes and Obesity

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor

(2010) Nazif Alic et al.   AGING CELL

Defensins play a crucial role in protecting mice against oral Shigella flexneri infection

(2010) Doo-Hee Shim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication

(2010) Kathryn M Castorena et al.   BMC GENOMICS

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism

(2010) Sylvie Rabot et al.   FASEB JOURNAL

New research resources at the Bloomington Drosophila Stock Center

(2010) Kevin R. Cook et al.   FLY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Microbiota restoration: natural and supplemented recovery of human microbial communities

(2010) Gregor Reid et al.   NATURE REVIEWS MICROBIOLOGY

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

(2010) F. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Back to the Future: Studying Cholera Pathogenesis Using Infant Rabbits

(2010) J. M. Ritchie et al.   mBio

Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones

(2009) Zaza Kokrashvili et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Intestinal lipid absorption

(2009) Jahangir Iqbal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular mechanisms of metabolic regulation by insulin inDrosophila

(2009) Aurelio A. Teleman   BIOCHEMICAL JOURNAL

Peptidergic paracrine and endocrine cells in the midgut of the fruit fly maggot

(2009) Jan A. Veenstra   CELL AND TISSUE RESEARCH

The DHR96 Nuclear Receptor Controls Triacylglycerol Homeostasis in Drosophila

(2009) Matthew H. Sieber et al.   Cell Metabolism

Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila

(2009) Alla Amcheslavsky et al.   Cell Stem Cell

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

(2009) Tim van Opijnen et al.   NATURE METHODS

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia

(2009) Y. Apidianakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis

(2009) Atsuhiko Ichimura et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The Role of Anorexia in Resistance and Tolerance to Infections in Drosophila

(2009) Janelle S. Ayres et al.   PLOS BIOLOGY

The TOR Pathway Couples Nutrition and Developmental Timing in Drosophila

(2008) Sophie Layalle et al.   DEVELOPMENTAL CELL

Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding

(2008) P.D. Cani et al.   PATHOLOGIE BIOLOGIE

Bitter Taste Receptors Influence Glucose Homeostasis

(2008) Cedrick D. Dotson et al.   PLoS One