TGFβ/BMP Signaling Pathway in Cartilage Homeostasis

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

(2019) Song Ho Chang et al.   Nature Communications

TGF-β dampens IL-6 signaling in articular chondrocytes by decreasing IL-6 receptor expression

(2019) R. Wiegertjes et al.   OSTEOARTHRITIS AND CARTILAGE

Collagen Damage Location in Articular Cartilage Differs if Damage is Caused by Excessive Loading Magnitude or Rate

(2018) Lorenza Henao-Murillo et al.   ANNALS OF BIOMEDICAL ENGINEERING

IL-6 in Osteoarthritis: Effects of Pine Stilbenoids

(2018) Mirka Laavola et al.   MOLECULES

Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model

(2017) H. Iijima et al.   OSTEOARTHRITIS AND CARTILAGE

Thinning of articular cartilage after joint unloading or immobilization. An experimental investigation of the pathogenesis in mice

(2017) M. Nomura et al.   OSTEOARTHRITIS AND CARTILAGE

Knee osteoarthritis has doubled in prevalence since the mid-20th century

(2017) Ian J. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling

(2017) Christian Siebold et al.   TRENDS IN CELL BIOLOGY

BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells

(2016) Nian Zhou et al.   CELL AND TISSUE RESEARCH

Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding

(2016) Senem Aykul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage

(2016) W. Madej et al.   OSTEOARTHRITIS AND CARTILAGE

Unloading results in rapid loss of TGFβ signaling in articular cartilage: role of loading-induced TGFβ signaling in maintenance of articular chondrocyte phenotype?

(2016) W. Madej et al.   OSTEOARTHRITIS AND CARTILAGE

Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors

(2016) A. van Caam et al.   OSTEOARTHRITIS AND CARTILAGE

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

(2016) Bo Yan et al.   Nature Communications

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate

(2016) Weiguang Wang et al.   PLoS Genetics

Attenuation of the Progression of Articular Cartilage Degeneration by Inhibition of TGF-β1 Signaling in a Mouse Model of Osteoarthritis

(2015) Rebecca Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

GDF-5 can act as a context-dependent BMP-2 antagonist

(2015) Uwe Klammert et al.   BMC BIOLOGY

Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age

(2015) Kahaer Abula et al.   FEBS LETTERS

Hyaluronan inhibits BMP-induced osteoblast differentiation

(2015) Keiko Kaneko et al.   FEBS LETTERS

Cartilage degeneration and excessive subchondral bone formation in spontaneous osteoarthritis involves altered TGF-β signaling

(2015) Weiwei Zhao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways

(2015) YANHUI ZHU et al.   Molecular Medicine Reports

The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGFβ1

(2015) A. van Caam et al.   OSTEOARTHRITIS AND CARTILAGE

PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation

(2015) Jason S. L. Yu et al.   Nature Communications

BAPX-1/NKX-3.2 Acts as a Chondrocyte Hypertrophy Molecular Switch in Osteoarthritis

(2015) Marjolein M. J. Caron et al.   Arthritis & Rheumatology

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage

(2014) E N Blaney Davidson et al.   ANNALS OF THE RHEUMATIC DISEASES

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

(2014) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Definition of Smad3 Phosphorylation Events That Affect Malignant and Metastatic Behaviors in Breast Cancer Cells

(2014) E. Bae et al.   CANCER RESEARCH

Dynamics and Cellular Localization ofBmp2,Bmp4, andNogginTranscription in the Postnatal Mouse Skeleton

(2014) Steven K Pregizer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genesis and morphogenesis of limb synovial joints and articular cartilage

(2014) Rebekah S. Decker et al.   MATRIX BIOLOGY

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling

(2014) W. Madej et al.   OSTEOARTHRITIS AND CARTILAGE

Human Chondrocytes Respond Discordantly to the Protein Encoded by the Osteoarthritis Susceptibility Gene GDF5

(2014) Madhushika Ratnayake et al.   PLoS One

SMAD3 Is Associated with the Total Burden of Radiographic Osteoarthritis: The Chingford Study

(2014) Erfan Aref-Eshghi et al.   PLoS One

TGF-β signaling to chromatin: How Smads regulate transcription during self-renewal and differentiation

(2014) Tessa Gaarenstroom et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma

(2014) Miki Murata   WORLD JOURNAL OF GASTROENTEROLOGY

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

(2014) Koji Takayama et al.   ARTHRITIS RESEARCH & THERAPY

The Tumor Suppressor Smad4/DPC4 Is Regulated by Phosphorylations that Integrate FGF, Wnt, and TGF-β Signaling

(2014) Hadrien Demagny et al.   Cell Reports

Aging and Oxidative Stress Reduce the Response of Human Articular Chondrocytes to Insulin-like Growth Factor 1 and Osteogenic Protein 1

(2014) Richard F. Loeser et al.   Arthritis & Rheumatology

CD44 and Hyaluronan Promote the Bone Morphogenetic Protein 7 Signaling Response in Murine Chondrocytes

(2014) Na Luo et al.   Arthritis & Rheumatology

Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis-like Phenotype in Mice

(2013) Jie Shen et al.   ARTHRITIS AND RHEUMATISM

Transforming growth factor-β signalling: Role and consequences of Smad linker region phosphorylation

(2013) Danielle Kamato et al.   CELLULAR SIGNALLING

Smad phospho-isoforms direct context-dependent TGF-β signaling

(2013) Koichi Matsuzaki   CYTOKINE & GROWTH FACTOR REVIEWS

Oral Administration of Transforming Growth Factor-β1 (TGF-β1) Protects the Immature Gut from Injury via Smad Protein-dependent Suppression of Epithelial Nuclear Factor κB (NF-κB) Signaling and Proinflammatory Cytokine Production

(2013) Sheng-Ru Shiou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic mechanical compression of devitalized articular cartilage does not activate latent TGF-β

(2013) Michael B. Albro et al.   JOURNAL OF BIOMECHANICS

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages

(2013) Lin Gao et al.   JOURNAL OF CELL SCIENCE

Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7

(2013) M.M.J. Caron et al.   OSTEOARTHRITIS AND CARTILAGE

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis

(2012) Carol G. Chen et al.   ARTHRITIS AND RHEUMATISM

Mechanisms involved in inhibition of chondrogenesis by activin-A

(2012) Sho Mitsugi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Biomechanics-driven chondrogenesis: from embryo to adult

(2012) Donald J. Responte et al.   FASEB JOURNAL

Phosphatases in SMAD regulation

(2012) David L. Bruce et al.   FEBS LETTERS

Promiscuity and specificity in BMP receptor activation

(2012) Thomas D. Mueller et al.   FEBS LETTERS

Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes

(2012) Kyung-Ok Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation

(2012) Tatsuya Sueyoshi et al.   MATRIX BIOLOGY

Shearing of synovial fluid activates latent TGF-β

(2012) M.B. Albro et al.   OSTEOARTHRITIS AND CARTILAGE

Dynamic Regulation of Bone Morphogenetic Proteins in Engineered Osteochondral Constructs by Biomechanical Stimulation

(2012) Jin Nam et al.   TISSUE ENGINEERING PART A

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Smad phosphoisoform signaling specificity: the right place at the right time

(2011) Koichi Matsuzaki   CARCINOGENESIS

Role of Smads in TGFβ signaling

(2011) Carl-Henrik Heldin et al.   CELL AND TISSUE RESEARCH

BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain

(2011) Marie Bidart et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

(2011) Ingrid M B H van de Laar et al.   JOURNAL OF MEDICAL GENETICS

Differential response of cartilage oligomeric matrix protein (COMP) to morphogens of bone morphogenetic protein/transforming growth factor-β family in the surface, middle and deep zones of articular cartilage

(2011) Shirley C. K. M. Motaung et al.   Journal of Tissue Engineering and Regenerative Medicine

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Relation of synovitis to knee pain using contrast-enhanced MRIs

(2010) K. Baker et al.   ANNALS OF THE RHEUMATIC DISEASES

Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study

(2010) A. Guermazi et al.   ANNALS OF THE RHEUMATIC DISEASES

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor β-activated kinase 1/activating transcription factor 2 signaling: A potential clinical implication for osteoarthritis

(2010) Tian-Fang Li et al.   ARTHRITIS AND RHEUMATISM

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Regulation of TGF-β signalling by protein phosphatases

(2010) Ting Liu et al.   BIOCHEMICAL JOURNAL

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

(2010) David J Hunter et al.   BMC MUSCULOSKELETAL DISORDERS

MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-β1/Smads pathway

(2010) J. Li et al.   CELL PROLIFERATION

Bone Morphogenetic Proteins: A critical review

(2010) Beth Bragdon et al.   CELLULAR SIGNALLING

The TAK1–TRAF6 signalling pathway

(2010) Marene Landström   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Prodomains of Transforming Growth Factor β (TGFβ) Superfamily Members Specify Different Functions

(2010) Gerhard Sengle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways

(2010) Lea M Gunnell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

BMP-7–induced ectopic bone formation and fracture healing is impaired by systemic NSAID application in C57BL/6-mice

(2010) Alexander S. Spiro et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Collagen Structure and Stability

(2009) Matthew D. Shoulders et al.   Annual Review of Biochemistry

Effect of interleukin-1β on osteogenic protein 1-induced signaling in adult human articular chondrocytes

(2009) Amel M. Elshaier et al.   ARTHRITIS AND RHEUMATISM

Rho kinase–dependent activation of SOX9 in chondrocytes

(2009) Dominik R. Haudenschild et al.   ARTHRITIS AND RHEUMATISM

XIAP as a ubiquitin ligase in cellular signaling

(2009) S Galbán et al.   CELL DEATH AND DIFFERENTIATION

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Akt regulates skeletal development through GSK3, mTOR, and FoxOs

(2009) Satoshi Rokutanda et al.   DEVELOPMENTAL BIOLOGY

TAK1 is an essential regulator of BMP signalling in cartilage

(2009) Jae-Hyuck Shim et al.   EMBO JOURNAL

A Negative Feedback Control of Transforming Growth Factor-β Signaling by Glycogen Synthase Kinase 3-mediated Smad3 Linker Phosphorylation at Ser-204

(2009) Caroline Millet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

ERK1/2 Activation Induced by Inflammatory Cytokines Compromises Effective Host Tissue Integration of Engineered Cartilage

(2009) Farida Djouad et al.   TISSUE ENGINEERING PART A

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis

(2008) F Pessler et al.   ANNALS OF THE RHEUMATIC DISEASES

Differential upregulation of the three transforming growth factor beta isoforms in human osteoarthritic cartilage

(2008) M Pombo-Suarez et al.   ANNALS OF THE RHEUMATIC DISEASES

Nucleocytoplasmic shuttling of Smad proteins

(2008) Caroline S Hill   CELL RESEARCH

Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-Induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation

(2008) Amjad Javed et al.   CELLS TISSUES ORGANS

Effects induced by BMPS in cultures of human articular chondrocytes: Comparative studies

(2008) Susan Chubinskaya et al.   GROWTH FACTORS

Structural Coupling of Smad and Runx2 for Execution of the BMP2 Osteogenic Signal

(2008) Amjad Javed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALK1 Opposes ALK5/Smad3 Signaling and Expression of Extracellular Matrix Components in Human Chondrocytes

(2008) Kenneth W Finnson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A New Model for Growth Factor Activation: Type II Receptors Compete with the Prodomain for BMP-7

(2008) Gerhard Sengle et al.   JOURNAL OF MOLECULAR BIOLOGY

BMP-7 protects against progression of cartilage degeneration after impact injury

(2008) Mark Hurtig et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study

(2008) G. Tardif et al.   OSTEOARTHRITIS AND CARTILAGE

Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage

(2008) R.F. Loeser et al.   OSTEOARTHRITIS AND CARTILAGE

Hyaluronan promotes the chondrocyte response to BMP-7

(2008) R.A. Andhare et al.   OSTEOARTHRITIS AND CARTILAGE

Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression

(2008) Masaya Hayashi et al.   ARTHRITIS RESEARCH & THERAPY

The protective effect of OP-1 on articular cartilage in the development of osteoarthritis

(2007) N. Badlani et al.   OSTEOARTHRITIS AND CARTILAGE