Article
Biochemistry & Molecular Biology
Roshan Kumari, Maria Johnson Irudayam, Qusai Al Abdallah, Tamekia L. Jones, Tahliyah S. Mims, Michelle A. Puchowicz, Joseph F. Pierre, Chester W. Brown
Summary: Adipose tissue is crucial for energy storage and other functions; SMAD2 and SMAD3 proteins play important roles in adipocyte function; SMAD3 is identified as an important contributor to the maintenance of subcutaneous white adipose tissue.
Article
Multidisciplinary Sciences
Jilai Zhao, Jatin Patel, Simranpreet Kaur, Seen-Ling Sim, Ho Yi Wong, Cassandra Styke, Isabella Hogan, Sam Kahler, Hamish Hamilton, Racheal Wadlow, James Dight, Ghazaleh Hashemi, Laura Sormani, Edwige Roy, Mervin C. Yoder, Mathias Francois, Kiarash Khosrotehrani
Summary: The regulation of endothelial to mesenchymal transition in endovascular progenitors involves the expression of Sox9 and Rbpj, with blocking Sox9 affecting the transition and scarring size in skin wounds, while changes in Rbpj have the opposite effect.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Shu Yang, Guangyan Yang, Xinyu Wang, Jiaqing Xiang, Lin Kang, Zhen Liang
Summary: This study demonstrates the anti-fibrotic role of SIRT2 in renal tubules and hepatocytes. SIRT2 inhibits fibrotic gene expression by reducing the activation of the TGF-beta signaling pathway. It interacts with and deacetylates SMAD2 and SMAD3 to promote their degradation and decrease the activation of SMAD3.
CELL DEATH & DISEASE
(2023)
Article
Endocrinology & Metabolism
Hongyuan Zhang, Vijitha Puviindran, Puviindran Nadesan, Xiruo Ding, Leyao Shen, Yuning J. Tang, Hidetoshi Tsushima, Yasuhito Yahara, Ga Ban, Guo-Fang Zhang, Courtney M. Karner, Benjamin A. Alman
Summary: This study demonstrates the distinct roles of glutamine metabolism in enchondromas and chondrosarcomas with IDH1 or IDH2 mutations. Glutamine promotes cell differentiation and proliferation in enchondromas, while inhibiting glutaminase reduces overall tumor burden in chondrosarcomas. These findings suggest potential therapeutic approaches to suppress the growth of enchondroma and chondrosarcoma tumors through modulation of glutamine metabolism.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hui Lin, Xian Xu, Kelie Chen, Zhiqin Fu, Shengchao Wang, Yaqing Chen, Honghe Zhang, Yuequn Niu, Hanwen Chen, Hongfei Yu, Jian-zhong Shao, Weiguo Lu, Yihua Wu, Dajing Xia
Summary: This paper explores the functional role and molecular mechanism of long noncoding RNA CASC15 in ovarian cancer. In vitro and in vivo experiments validate CASC15 as an oncogenic gene that enhances metastasis in ovarian cancer. It is shown that miR-23b-3p and miR-24-3p directly target CASC15 and CASC15 regulates SMAD3 expression through these microRNAs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xiaoyue Zhang, Mengjia Weng, Zhenqi Chen
Summary: FGF9 plays a crucial role in early chondrogenesis, partly through the AKT/GSK-3 β pathway, regulating cartilage matrix formation and gene expression. Inhibition of FGF9 suppresses AKT and GSK-3 β phosphorylation, leading to inhibited chondrocyte differentiation, which can be compensated by the activation of AKT.
Article
Pharmacology & Pharmacy
Siqi Liu, Bingyu Shen, Juan J. Loor, Qianming Jiang, Yang Yuan, Yezi Kong, Panpan Tan, Fangyuan Zeng, Chenxu Zhao, Xiaoyan Zhu, Jianguo Wang
Summary: The present study evaluated the effects of strontium on the proliferation and differentiation of chondrocytes. It was found that strontium promotes cell proliferation and inhibits cell differentiation by directing TGF beta signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Alison Ramser, Elizabeth Greene, Narayan Rath, Sami Dridi
Summary: Lameness is a significant issue in the poultry industry due to bone diseases and infections in fast-growing broilers. The lack of immortalized chondrocyte cell lines has hindered the study of these disorders. This study successfully isolated and cultured primary chondrocytes from newborn chicks and identified their optimal phenotypes and functionality. The results provide a basis for disease modeling and future research using avian primary chondrocytes.
Article
Biochemistry & Molecular Biology
Asra Almubarak, Rotem Lavy, Nikola Srnic, Yawen Hu, Devi Priyanka Maripuri, Tsutomo Kume, Fred B. Berry
Summary: Foxc1 and Foxc2 play important roles in chondrocyte differentiation and function, as their loss results in disorganization of the growth plate, reduced chondrocyte proliferation, and delays in chondrocyte hypertrophy, thereby preventing ossification of the skeleton.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Anatomy & Morphology
Zhuoyu Zhang, Guoliang Sa, Zhuo Wang, Zequan Wei, Liwu Zheng, Ruochen Zhang, Xinbiao Zhu, Xuewen Yang
Summary: This study demonstrates that Piezo1 and IFT88 may play a synergistic role in regulating the differentiation of mandibular condyle chondrocytes under mechanical conduction.
Article
Biochemistry & Molecular Biology
Anthony J. Hayes, John Whitelock, James Melrose
Summary: The aim of this study was to investigate the roles of perlecan in the regulation of cartilage development and homeostasis. The study showed that perlecan interacts with various molecules to promote matrix stabilization, cellular proliferation, and tissue expansion. Furthermore, perlecan is involved in chromatin structure modulation and gene regulation. Snail-1 and FGF family members play important roles in chondrogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Daian Pan, Jinghong Zhong, Jingcheng Zhang, Haisi Dong, Daqing Zhao, He Zhang, Baojin Yao
Summary: This study aims to reveal the influence of Nfix on the proliferation and differentiation of chondrocytes, and to explore its potential action mechanism. The results showed that Nfix overexpression promoted extracellular matrix (ECM) synthesis in chondrocytes, while silencing inhibited it. Furthermore, Nfix exerted a positive regulatory effect on Sox9, which may promote chondrocyte proliferation and inhibit differentiation. These findings suggest that Nfix may be a potential target for the regulation of chondrocyte proliferation and differentiation.
Review
Biochemistry & Molecular Biology
Estera Rintz, Grzegorz Wegrzyn, Toshihito Fujii, Shunji Tomatsu
Summary: The process of skeletal development in the body, known as endochondral ossification, is regulated by natriuretic peptides, including C-type natriuretic peptide (CNP), which promotes bone growth through various mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Chunmei Xiu, Tingting Gong, Na Luo, Linghui Ma, Lei Zhang, Jianquan Chen
Summary: This study provides the first genetic evidence to establish the essential cell-autonomous roles for tightly-regulated Hh signaling in epiphyseal growth plate maintenance and limb elongation during juvenile growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoxiao Xu, Chang Yang, Xijie Yu, Jiawei Wang
Summary: Fibulin-3 modulates the chondrogenic differentiation of ATDC5 cells in inflammation through the partial suppression of the TGF-beta/Smad3 signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Diana Rigueur, Sean Brugger, Teni Anbarchian, Jong Kil Kim, YooJin Lee, Karen M. Lyons
JOURNAL OF BONE AND MINERAL RESEARCH
(2015)
Article
Plant Sciences
Maskit Maymon, Pilar Martinez-Hidalgo, Stephen S. Tran, Tyler Ice, Karena Craemer, Teni Anbarchian, Tiffany Sung, Lin H. Hwang, Minxia Chou, Nancy A. Fujishige, William Villella, Jerome Ventosa, Johannes Sikorski, Erin R. Sanders, Kym F. Faull, Ann M. Hirsch
FRONTIERS IN PLANT SCIENCE
(2015)
Article
Multidisciplinary Sciences
Alejandro Burga, Weiguang Wang, Eyal Ben-David, Paul C. Wolf, Andrew M. Ramey, Claudio Verdugo, Karen Lyons, Patricia G. Parker, Leonid Kruglyak
Article
Multidisciplinary Sciences
Liujing Xing, Teni Anbarchian, Jonathan M. Tsai, Giles W. Plant, Roeland Nusse
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Developmental Biology
Kristine D. Estrada, Weiguang Wang, Kelsey N. Retting, Chengan T. Chien, Fuad E. Elkhoury, Rainer Heuchel, Karen M. Lyons
DEVELOPMENTAL BIOLOGY
(2013)
Article
Oncology
Wenwen Chien, James O'Kelly, Daning Lu, Amanda Leiter, Julia Sohn, Dong Yin, Beth Karlan, Jay Vadgama, Karen M. Lyons, H. Phillip Koeffler
INTERNATIONAL JOURNAL OF ONCOLOGY
(2011)
Article
Endocrinology & Metabolism
Takashi Nishida, Kenji Emura, Satoshi Kubota, Karen M. Lyons, Masaharu Takigawa
JOURNAL OF BONE AND MINERAL RESEARCH
(2011)
Article
Biochemistry & Molecular Biology
Weng Chuan Peng, Catriona Y. Logan, Matt Fish, Teni Anbarchian, Francis Aguisanda, Adrian Alvarez-Varela, Peng Wu, Yinhua Jin, Junjie Zhu, Bin Li, Markus Grompe, Bruce Wang, Roel Nusse
Review
Endocrinology & Metabolism
Weiguang Wang, Diana Rigueur, Karen M. Lyons
Article
Endocrinology & Metabolism
Gexin Zhao, Elliot W. Kim, Jie Jiang, Chimay Bhoot, Kemberly R. Charles, Jongseung Baek, Subburaman Mohan, John S. Adams, Sotirios Tetradis, Karen M. Lyons
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Multidisciplinary Sciences
Yinhua Jin, Teni Anbarchian, Peng Wu, Abby Sarkar, Matt Fish, Weng Chuan Peng, Roel Nusse
Summary: Cell proliferation is tightly regulated by various factors, including transcriptional repressors E2F7 and E2F8. In this study, it was discovered that Wnt/β-catenin signaling maintains active cell division in the liver through the transcription factor Tbx3. Tbx3 directly represses the transcription of E2f7 and E2f8, thereby promoting mitosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Abby Sarkar, Yinhua Jin, Brian C. DeFelice, Catriona Y. Logan, Yan Yang, Teni Anbarchian, Peng Wu, Maurizio Morri, Norma F. Neff, Huy Nguyen, Eric Rulifson, Matthew Fish, Avi Gurion Kaye, Azalia M. Martinez Jaimes, Roel Nusse, Pramod Mistry
Summary: Intermittent fasting promotes rapid hepatocyte proliferation and maintains liver homeostasis. This study challenges the widely held view that liver tissue is mostly quiescent and provides the first example of dietary influence on adult hepatocyte proliferation.
Meeting Abstract
Biochemistry & Molecular Biology
T. Nishida, K. Emura, S. Kubota, K. M. Lyons, M. Takigawa