Potassium channel dysfunction in neurons and astrocytes in Huntington's disease

Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke

(2017) Chung-Yang Yeh et al.   JOURNAL OF NEUROSCIENCE

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology

(2017) Monia Barnat et al.   NEURON

Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease

(2017) Baljit S. Khakh et al.   TRENDS IN NEUROSCIENCES

Metabolic profiling of presymptomatic Huntington’s disease sheep reveals novel biomarkers

(2017) Debra J. Skene et al.   Scientific Reports

The role of glial-specific Kir4.1 in normal and pathological states of the CNS

(2016) Sinifunanya E. Nwaobi et al.   ACTA NEUROPATHOLOGICA

Expression of Kir4.1 and Kir5.1 inwardly rectifying potassium channels in oligodendrocytes, the myelinating cells of the CNS

(2016) C. Brasko et al.   Brain Structure & Function

Corticostriatal Dysfunction in Huntington’s Disease: The Basics

(2016) Kendra D. Bunner et al.   Frontiers in Human Neuroscience

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

(2016) Anne H.P. Jansen et al.   GLIA

KCNT1mutations in seizure disorders: the phenotypic spectrum and functional effects

(2016) Chiao Xin Lim et al.   JOURNAL OF MEDICAL GENETICS

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

(2016) R. Jiang et al.   JOURNAL OF NEUROSCIENCE

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

(2016) Abdellatif Benraiss et al.   Nature Communications

Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

(2016) Jeremy F Atherton et al.   eLife

Tau-Dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer's Disease

(2015) Alicia M. Hall et al.   JOURNAL OF NEUROSCIENCE

The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study

(2015) Elisa De Franco et al.   LANCET

Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels

(2015) Glenn M. Dallérac et al.   Neurodegenerative Diseases

Mutant Huntingtin Downregulates Myelin Regulatory Factor-Mediated Myelin Gene Expression and Affects Mature Oligodendrocytes

(2015) Brenda Huang et al.   NEURON

Dopamine midbrain neurons in health and Parkinson’s disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels

(2015) E. Dragicevic et al.   NEUROSCIENCE

Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington’s disease

(2015) Yumei Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Protective effects of phosphodiesterase-1 (PDE1) and ATP sensitive potassium (KATP) channel modulators against 3-nitropropionic acid induced behavioral and biochemical toxicities in experimental Huntington׳s disease

(2014) Surbhi Gupta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Potassium Channels: Structures, Diseases, and Modulators

(2013) Chuan Tian et al.   Chemical Biology & Drug Design

Voltage-gated and ATP-sensitive K+ channels are associated with cell proliferation and tumorigenesis of human glioma

(2013) QIN RU et al.   ONCOLOGY REPORTS

Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction

(2013) C. W. Waters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Introduction to Ion Channels and Disease

(2012) John J. Kasianowicz   CHEMICAL REVIEWS

Targeting SKCa Channels in Cancer: Potential New Therapeutic Approaches

(2012) A. Girault et al.   CURRENT MEDICINAL CHEMISTRY

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease

(2011) Pengxiang She et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Age, CAG repeat length, and clinical progression in Huntington's disease

(2011) Adam Rosenblatt et al.   MOVEMENT DISORDERS

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

(2010) M. Faideau et al.   HUMAN MOLECULAR GENETICS

Neuroinflammation in Huntington’s disease

(2010) Thomas Möller   JOURNAL OF NEURAL TRANSMISSION

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Homeostatic Regulation of Neuronal Excitability by K+ Channels in Normal and Diseased Brains

(2010) Hiroaki Misonou   NEUROSCIENTIST

Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis

(2009) Xiaofang Tang et al.   GLIA

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

(2009) Jennifer Bradford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

(2008) Maria Björkqvist et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coupling of L-Type Ca2+ Channels to KV7/KCNQ Channels Creates a Novel, Activity-Dependent, Homeostatic Intrinsic Plasticity

(2008) Wendy W. Wu et al.   JOURNAL OF NEUROPHYSIOLOGY

Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease

(2008) Jose A. Obeso et al.   MOVEMENT DISORDERS

Towards a transgenic model of Huntington’s disease in a non-human primate

(2008) Shang-Hsun Yang et al.   NATURE

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

(2008) Akiko Nishiyama et al.   NATURE REVIEWS NEUROSCIENCE

Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons

(2008) Helene Vacher et al.   PHYSIOLOGICAL REVIEWS