Corticostriatal Dysfunction in Huntington’s Disease: The Basics

The Prevalence of Huntington's Disease

(2016) Michael D. Rawlins et al.   NEUROEPIDEMIOLOGY

Cortical Efferents Lacking Mutant huntingtin Improve Striatal Neuronal Activity and Behavior in a Conditional Mouse Model of Huntington's Disease

(2015) A. M. Estrada-Sanchez et al.   JOURNAL OF NEUROSCIENCE

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels

(2015) Glenn M. Dallérac et al.   Neurodegenerative Diseases

Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy

(2015) Xiao-Jiang Li et al.   Drug Design Development and Therapy

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Astrocytes and Huntington’s Disease

(2014) Baljit S. Khakh et al.   ACS Chemical Neuroscience

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Huntington’s disease: pathogenesis to animal models

(2014) Puneet Kumar et al.   Pharmacological Reports

Multiple Sources of Striatal Inhibition Are Differentially Affected in Huntington's Disease Mouse Models

(2013) C. Cepeda et al.   JOURNAL OF NEUROSCIENCE

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia

(2013) Anton Reiner et al.   MOVEMENT DISORDERS

Concurrent activation of striatal direct and indirect pathways during action initiation

(2013) Guohong Cui et al.   NATURE

Corticostriatal connectivity and its role in disease

(2013) Gordon M. G. Shepherd   NATURE REVIEWS NEUROSCIENCE

Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model

(2013) William Lee et al.   NEUROBIOLOGY OF DISEASE

Role of cerebral cortex in the neuropathology of Huntington's disease

(2013) Ana M. Estrada-Sánchez et al.   Frontiers in Neural Circuits

Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility

(2013) Jane Y. Chen et al.   Frontiers in Neuroscience

Motor function and dopamine release measurements in transgenic Huntington's disease model rats

(2012) Andrea N. Ortiz et al.   BRAIN RESEARCH

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

(2012) M. A. Pouladi et al.   HUMAN MOLECULAR GENETICS

Up-regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington’s disease

(2012) Benjamin R. Miller et al.   JOURNAL OF NEUROCHEMISTRY

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

(2012) Taneli Heikkinen et al.   PLoS One

Dysfunctional Behavioral Modulation of Corticostriatal Communication in the R6/2 Mouse Model of Huntington’s Disease

(2012) S. Lee Hong et al.   PLoS One

Behavioral and In Vivo Electrophysiological Evidence for Presymptomatic Alteration of Prefrontostriatal Processing in the Transgenic Rat Model for Huntington Disease

(2011) S. Hohn et al.   JOURNAL OF NEUROSCIENCE

Local field potential oscillations of the globus pallidus in Huntington's disease

(2011) Stefan Jun Groiss et al.   MOVEMENT DISORDERS

Reduced expression of conditioned fear in the R6/2 mouse model of Huntington's disease is related to abnormal activity in prelimbic cortex

(2011) Adam G. Walker et al.   NEUROBIOLOGY OF DISEASE

Impaired dopamine release and uptake in R6/1 Huntington's disease model mice

(2011) Andrea N. Ortiz et al.   NEUROSCIENCE LETTERS

Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington disease

(2011) S. Cayzac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

(2010) M. Faideau et al.   HUMAN MOLECULAR GENETICS

Hyperdopaminergic Status in Experimental Huntington Disease

(2010) Ali Jahanshahi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles of GABAergic Interneurons in the Regulation of Striatal Output Pathways

(2010) A. H. Gittis et al.   JOURNAL OF NEUROSCIENCE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Glycolysis Inhibition Decreases the Levels of Glutamate Transporters and Enhances Glutamate Neurotoxicity in the R6/2 Huntington′s Disease Mice

(2010) Ana María Estrada-Sánchez et al.   NEUROCHEMICAL RESEARCH

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

(2010) H. S. Bateup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

(2010) Austen J. Milnerwood et al.   TRENDS IN NEUROSCIENCES

Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids

(2009) Véronique M. André et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dysregulation of intracellular dopamine stores revealed in the R6/2 mouse striatum

(2009) Andrea N. Ortiz et al.   JOURNAL OF NEUROCHEMISTRY

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

D2R striatopallidal neurons inhibit both locomotor and drug reward processes

(2009) Pierre F Durieux et al.   NATURE NEUROSCIENCE

Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters

(2009) Ana María Estrada-Sánchez et al.   NEUROBIOLOGY OF DISEASE

Excitotoxic Neuronal Death and the Pathogenesis of Huntington's Disease

(2008) Ana María Estrada Sánchez et al.   ARCHIVES OF MEDICAL RESEARCH

Changes in striatal dopamine D2 receptor binding in pre-clinical Huntington’s disease

(2008) J.C.H. van Oostrom et al.   EUROPEAN JOURNAL OF NEUROLOGY

Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons

(2008) Carlos Cepeda et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Altered Information Processing in the Prefrontal Cortex of Huntington's Disease Mouse Models

(2008) A. G. Walker et al.   JOURNAL OF NEUROSCIENCE

Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

(2008) M. Gray et al.   JOURNAL OF NEUROSCIENCE

Striatal Plasticity and Basal Ganglia Circuit Function

(2008) Anatol C. Kreitzer et al.   NEURON

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

(2008) M.A. Hickey et al.   NEUROSCIENCE

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

(2008) B.R. Miller et al.   NEUROSCIENCE

Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement

(2006) P M Beart et al.   BRITISH JOURNAL OF PHARMACOLOGY