Positive transcription elongation factor b and its regulators in development

Cyclin-dependent kinase-9 is a therapeutic target in MYC-expressing diffuse large B-cell lymphoma

(2019) Taylor Hashiguchi et al.   MOLECULAR CANCER THERAPEUTICS

CDK9 inhibitors in acute myeloid leukemia

(2018) Silvia Boffo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CDK9: A key player in cancer and other diseases

(2017) Lia Carolina Franco et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response

(2017) Mehdi Morchikh et al.   MOLECULAR CELL

SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs

(2017) Lihua Shii et al.   MOLECULAR IMMUNOLOGY

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

(2017) Christopher C. Ebmeier et al.   Cell Reports

RNA polymerase II pausing as a context-dependent reader of the genome

(2016) Adam Scheidegger et al.   Biochemistry and Cell Biology

Inhibition of P-TEFb disrupts global transcription, oocyte maturation, and embryo development in the mouse

(2016) Reza K. Oqani et al.   GENESIS

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

(2016) Justin L. Tan et al.   MOLECULAR CELL

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II

(2016) Ryan P. McNamara et al.   MOLECULAR CELL

Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal

(2016) Manya Dhar-Mascareno et al.   MOLECULAR ENDOCRINOLOGY

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

(2016) Leehee Weinberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter

(2015) Andreas H. Wagner et al.   BIOCHEMICAL PHARMACOLOGY

Repression of somatic cell fate in the germline

(2015) Valérie J. Robert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells

(2015) Juliane Arter et al.   JOURNAL OF NEUROCHEMISTRY

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

(2015) Giorgio G. Galli et al.   MOLECULAR CELL

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

(2015) M. Yu et al.   SCIENCE

The Nature of Embryonic Stem Cells

(2014) Graziano Martello et al.   Annual Review of Cell and Developmental Biology

HEXIM1 plays a critical role in the inhibition of the androgen receptor by anti-androgens

(2014) I-Ju Yeh et al.   BIOCHEMICAL JOURNAL

Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming

(2014) Longqi Liu et al.   Cell Stem Cell

Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states

(2014) Jong-Hee Lee et al.   Nature Communications

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

(2014) Raffaella Di Micco et al.   Cell Reports

Primordial Dwarfism Gene Maintains Lin28 Expression to Safeguard Embryonic Stem Cells from Premature Differentiation

(2014) Qian Dai et al.   Cell Reports

The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis

(2014) Stefania Bottardi et al.   PLoS Genetics

Precise Developmental Gene Expression Arises from Globally Stochastic Transcriptional Activity

(2013) Shawn C. Little et al.   CELL

RNA Polymerase II Transcription Elongation Control

(2013) Jiannan Guo et al.   CHEMICAL REVIEWS

Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline

(2013) E. A. Bowman et al.   DEVELOPMENT

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

(2013) V. Proserpio et al.   GENES & DEVELOPMENT

Transcriptional elongation checkpoint control in development and disease

(2013) E. Smith et al.   GENES & DEVELOPMENT

Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription

(2013) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockbuster dreams for Pfizer's CDK inhibitor

(2013) Malini Guha   NATURE BIOTECHNOLOGY

Cardiomyocyte-Specific Overexpression of HEXIM1 Prevents Right Ventricular Hypertrophy in Hypoxia-Induced Pulmonary Hypertension in Mice

(2013) Noritada Yoshikawa et al.   PLoS One

SIRT2 directs the replication stress response through CDK9 deacetylation

(2013) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease

(2013) R. H. Oakley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extensive Cooperation of Immune Master Regulators IRF3 and NFκB in RNA Pol II Recruitment and Pause Release in Human Innate Antiviral Transcription

(2013) Jonathan E. Freaney et al.   Cell Reports

The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells

(2013) Gonçalo Castelo-Branco et al.   GENOME BIOLOGY

Contribution of GATA1 dysfunction to multi-step leukemogenesis

(2012) Ritsuko Shimizu et al.   CANCER SCIENCE

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes

(2012) Xiaoying Bai et al.   DEVELOPMENTAL BIOLOGY

Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells

(2012) D. Okamura et al.   GENES & DEVELOPMENT

Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein

(2012) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation

(2012) Irene Marchesi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration

(2012) Peng Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular basis of physiological heart growth: fundamental concepts and new players

(2012) Marjorie Maillet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Drosophila 7SK snRNP and the essential role of dHEXIM in development

(2012) Duy Nguyen et al.   NUCLEIC ACIDS RESEARCH

Control of the Embryonic Stem Cell State

(2011) Richard A. Young   CELL

A Maternal Factor Unique to Ascidians Silences the Germline via Binding to P-TEFb and RNAP II Regulation

(2011) Gaku Kumano et al.   CURRENT BIOLOGY

Mechanisms and pathways of growth failure in primordial dwarfism

(2011) A. Klingseisen et al.   GENES & DEVELOPMENT

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC)

(2011) C. Lin et al.   GENES & DEVELOPMENT

Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation

(2011) Siobhan K. O'Brien et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation

(2011) Stefania Bottardi et al.   NUCLEIC ACIDS RESEARCH

Multiple functions of Ldb1 required for  -globin activation during erythroid differentiation

(2010) S.-H. Song et al.   BLOOD

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration

(2010) J. Galatioto et al.   JOURNAL OF CELL SCIENCE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation

(2010) James A. Goodrich et al.   NATURE REVIEWS GENETICS

Positive Transcription Elongation Factor b Activity in Compensatory Myocardial Hypertrophy is Regulated by Cardiac Lineage Protein-1

(2009) Jorge Espinoza-Derout et al.   CIRCULATION RESEARCH

Regulation of Hox Gene Activity by Transcriptional Elongation in Drosophila

(2009) Vivek S. Chopra et al.   CURRENT BIOLOGY

Cyclin T2 Is Essential for Mouse Embryogenesis

(2009) J. Kohoutek et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes

(2009) J. S. Byun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Transcription by the Caenorhabditis elegans Germline Protein PIE-1: Genetic Evidence for Distinct Mechanisms Targeting Initiation and Elongation

(2008) Dolan Ghosh et al.   GENETICS

A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis

(2008) Nanhai He et al.   MOLECULAR CELL

Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells

(2008) Kazuko Hanyu-Nakamura et al.   NATURE

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

(2008) B. J. Krueger et al.   NUCLEIC ACIDS RESEARCH