Inhibition of P-TEFb disrupts global transcription, oocyte maturation, and embryo development in the mouse

P-TEFb Kinase Activity Is Essential for Global Transcription, Resumption of Meiosis and Embryonic Genome Activation in Pig

(2016) Reza K. Oqani et al.   PLoS One

Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation

(2015) Hong Liu et al.   MOLECULAR CELL

Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II via Transcriptional Elongation Control in Mitosis

(2015) Kaiwei Liang et al.   MOLECULAR CELL

P-TEFb, the Super Elongation Complex and Mediator Regulate a Subset of Non-paused Genes during Early Drosophila Embryo Development

(2015) Olle Dahlberg et al.   PLoS Genetics

Ctk1 Function Is Necessary for Full Translation Initiation Activity in Saccharomyces cerevisiae

(2014) Britta Coordes et al.   EUKARYOTIC CELL

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

(2014) Iris Jonkers et al.   eLife

Inferring the choreography of parental genomes during fertilization from ultralarge-scale whole-transcriptome analysis

(2013) S.-J. Park et al.   GENES & DEVELOPMENT

Cyclin-dependent Kinase 9 Links RNA Polymerase II Transcription to Processing of Ribosomal RNA

(2013) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes

(2013) M. C. Patel et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

(2013) Zhigang Xue et al.   NATURE

Halogenated nucleotide labeling of nascent RNAs reveals dynamic transcription in growing pig oocytes

(2012) Reza K. Oqani et al.   DEVELOPMENTAL DYNAMICS

Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes

(2012) D. Adhikari et al.   HUMAN MOLECULAR GENETICS

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development

(2012) K. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CDK9/Cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: A possible role in embryonic genome activation

(2011) Reza K Oqani et al.   BMC DEVELOPMENTAL BIOLOGY

A role for cdk9-cyclin k in maintaining genome integrity

(2011) David S. Yu et al.   CELL CYCLE

What does it take to make a developmentally competent mammalian egg?

(2011) M. Zuccotti et al.   HUMAN REPRODUCTION UPDATE

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9

(2010) Ulrike K. Schmerwitz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases

(2010) Gaetano Romano et al.   CELL CYCLE

Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing

(2010) Judith Pirngruber et al.   CELL CYCLE

Cyclin-dependent kinase 9–cyclin K functions in the replication stress response

(2010) David S Yu et al.   EMBO REPORTS

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleolus: structure/function relationship in RNA metabolism

(2010) Danièle Hernandez-Verdun et al.   Wiley Interdisciplinary Reviews-RNA

CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3′-end processing

(2009) Judith Pirngruber et al.   EMBO REPORTS

Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5

(2009) K. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-TEFb- the final frontier

(2009) Jiri Kohoutek   Cell Division

The multi-tasking P-TEFb complex

(2008) Vanessa Brès et al.   CURRENT OPINION IN CELL BIOLOGY

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

(2008) Sonja Baumli et al.   EMBO JOURNAL

Genomic RNA profiling and the programme controlling preimplantation mammalian development

(2008) C. E. Bell et al.   MOLECULAR HUMAN REPRODUCTION

The Maternal Nucleolus Is Essential for Early Embryonic Development in Mammals

(2008) S. Ogushi et al.   SCIENCE