Molecular basis of physiological heart growth: fundamental concepts and new players

IGF-IR signaling attenuates the age-related decline of diastolic cardiac function

(2012) Sarah Moellendorf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genetics of sudden cardiac death in children and young athletes

(2012) Georgia Sarquella-Brugada et al.   CARDIOLOGY IN THE YOUNG

Cardiomyogenesis in the Aging and Failing Human Heart

(2012) Jan Kajstura et al.   CIRCULATION

Exercise Training Prevents the Microvascular Rarefaction in Hypertension Balancing Angiogenic and Apoptotic Factors

(2012) Tiago Fernandes et al.   HYPERTENSION

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

(2012) Ian S. Patten et al.   NATURE

Truncations of Titin Causing Dilated Cardiomyopathy

(2012) Daniel S. Herman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The coronary circulation in exercise training

(2011) M. Harold Laughlin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy

(2011) E. D. Abel et al.   CARDIOVASCULAR RESEARCH

Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice

(2011) Pankaj Shende et al.   CIRCULATION

miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes

(2011) Enzo R. Porrello et al.   CIRCULATION RESEARCH

The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation

(2011) Junichi Tsukada et al.   CYTOKINE

Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin

(2011) A. J. Malhowski et al.   HUMAN MOLECULAR GENETICS

Translational potential of thyroid hormone and its analogs

(2011) Reza Arsanjani et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy

(2010) Izhak Kehat et al.   Annals of the New York Academy of Sciences

C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

(2010) Pontus Boström et al.   CELL

Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

(2010) Maija Bry et al.   CIRCULATION

Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth

(2010) Izhak Kehat et al.   CIRCULATION RESEARCH

Repression of CardiacPhospholambanGene Expression Is Mediated by Thyroid Hormone Receptor-α1 and Involves Targeted Covalent Histone Modifications

(2010) Madesh Belakavadi et al.   ENDOCRINOLOGY

Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation

(2010) Gary D Lopaschuk et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-27a Regulates Beta Cardiac Myosin Heavy Chain Gene Expression by Targeting Thyroid Hormone Receptor  1 in Neonatal Rat Ventricular Myocytes

(2010) H. Nishi et al.   MOLECULAR AND CELLULAR BIOLOGY

Canonical TRP channels and mechanotransduction: from physiology to disease states

(2010) Amanda Patel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies

(2010) Bianca C. Bernardo et al.   PHARMACOLOGY & THERAPEUTICS

TRPC channels are necessary mediators of pathologic cardiac hypertrophy

(2010) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Cardiac Phosphoinositide 3-Kinase p110α Results in Contractile Dysfunction

(2009) Zhongju Lu et al.   CIRCULATION

Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart

(2009) Sihem Boudina et al.   CIRCULATION

TRPC1 Channels Are Critical for Hypertrophic Signaling in the Heart

(2009) Malini Seth et al.   CIRCULATION RESEARCH

β3 Integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy

(2009) Rebecca K. Johnston et al.   FASEB JOURNAL

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

(2009) Thomas E. Callis et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction

(2009) Sandra Sena et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

AMPKα2 counteracts the development of cardiac hypertrophy induced by isoproterenol

(2008) Elham Zarrinpashneh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy

(2008) Terhi Karpanen et al.   CIRCULATION RESEARCH

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

EARLY ORIGINS OF CARDIAC HYPERTROPHY: DOES CARDIOMYOCYTE ATTRITION PROGRAMME FOR PATHOLOGICAL ‘CATCH-UP’ GROWTH OF THE HEART?

(2008) Enzo R Porrello et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice

(2008) Ping Zhang et al.   HYPERTENSION

A broken heart: A stretch too far

(2008) Luk Cox et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function

(2008) Wei-Hua Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes

(2008) Yanni Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

(2008) Jaetaek Kim et al.   MOLECULAR ENDOCRINOLOGY