Leishmania Spp-Host Interaction: There Is Always an Onset, but Is There an End?

Presence of parasite DNA in clinically unaffected nasal mucosa during Cutaneous Leishmaniasis caused by Leishmania (V.) braziliensis

(2019) Amanda Canário et al.   CLINICAL MICROBIOLOGY AND INFECTION

Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1

(2019) Katrin Paduch et al.   JOURNAL OF IMMUNOLOGY

Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites

(2019) Andrew W. Pountain et al.   PLoS Neglected Tropical Diseases

Iron superoxide dismutase contributes to miltefosine resistance in Leishmania donovani

(2019) Jalaja Veronica et al.   FEBS Journal

Leishmania infantum induces expression of the negative regulatory checkpoint, CTLA‐4, by human naïve CD8 + T cells

(2019) Agostinho Gonçalves Viana et al.   PARASITE IMMUNOLOGY

Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins

(2018) Daniel Kerr et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Is Visceral Leishmaniasis the same in HIV-coinfected adults?

(2018) Guilherme Alves de Lima Henn et al.   Brazilian Journal of Infectious Diseases

Leishmania amazonensis downregulates macrophage iNOS expression via Histone Deacetylase 1 (HDAC1): a novel parasite evasion mechanism

(2018) Teresa C. Calegari-Silva et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cytokines and chemokines differentially regulate innate immune cell trafficking during post kala-azar dermal leishmaniasis

(2018) Ashish K. Singh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Leishmania donovani infection differentially regulates small G-proteins

(2018) Atahar Husein et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IL-1β Production by Intermediate Monocytes Is Associated with Immunopathology in Cutaneous Leishmaniasis

(2018) Daniela Santos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increased thiol levels in antimony-resistant Leishmania infantum isolated from treatment-refractory visceral leishmaniasis in Brazil

(2018) Lucas S Magalhães et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Validation of rK39 immunochromatographic test and direct agglutination test for the diagnosis of Mediterranean visceral leishmaniasis in Spain

(2018) Mathieu Bangert et al.   PLoS Neglected Tropical Diseases

New insights into leishmaniasis in the immunosuppressed

(2018) Hannah Akuffo et al.   PLoS Neglected Tropical Diseases

Leishmania Infection Induces MicroRNA hsa-miR-346 in Human Cell Line-Derived Macrophages

(2018) Aurora Diotallevi et al.   Frontiers in Microbiology

The Binomial Parasite-Host Immunity in the Healing Process and in Reactivation of Human Tegumentary Leishmaniasis

(2018) Fatima Conceição-Silva et al.   Frontiers in Microbiology

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs

(2018) Alberto Rastrojo et al.   International Journal for Parasitology-Drugs and Drug Resistance

Infection of Human Monocytes with Leishmania infantum Strains Induces a Downmodulated Response when Compared with Infection with Leishmania braziliensis

(2018) Agostinho Gonçalves Viana et al.   Frontiers in Immunology

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

(2018) Shanshan Hu et al.   Frontiers in Immunology

Promastigote parasites cultured from the lesions of patients with mucosal leishmaniasis are more resistant to oxidative stress than promastigotes from a cutaneous lesion

(2018) Lucilla Ribeiro Ávila et al.   FREE RADICAL BIOLOGY AND MEDICINE

Leishmania infection activates host mTOR for its survival by M2 macrophage polarization

(2018) Ajay Kumar et al.   PARASITE IMMUNOLOGY

Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number

(2018) Daniel Yasur-Landau et al.   International Journal for Parasitology-Drugs and Drug Resistance

Distinct Roles for CD4+ Foxp3+ Regulatory T Cells and IL-10–Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani

(2018) Patrick T. Bunn et al.   JOURNAL OF IMMUNOLOGY

PD-1 blockade inhibits lymphocyte apoptosis and restores proliferation and anti-viral immune functions of lymphocyte after CP and NCP BVDV infection in vitro

(2018) Yu Liu et al.   VETERINARY MICROBIOLOGY

Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

(2018) Giovanni Bussotti et al.   mBio

Macrophage Polarization in Leishmaniasis: Broadening Horizons

(2018) Fernanda Tomiotto-Pellissier et al.   Frontiers in Immunology

Resistance of Leishmania (Viannia) Panamensis to Meglumine Antimoniate or Miltefosine Modulates Neutrophil Effector Functions

(2018) Ivo B. Regli et al.   Frontiers in Immunology

Potential impact of climate change on emerging vector-borne and other infections in the UK

(2017) Matthew Baylis   Environmental Health

Impact of climate variability on the occurrence of cutaneous leishmaniasis in Khuzestan Province, southwestern Iran

(2017) Farideh Azimi et al.   Geospatial Health

Mannose receptor high, M2 dermal macrophages mediate nonhealingLeishmania majorinfection in a Th1 immune environment

(2017) Sang Hun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor suppressor p53 induces apoptosis of host lymphocytes experimentally infected by Leishmania major, by activation of Bax and caspase-3: a possible survival mechanism for the parasite

(2017) Mozhgan Moshrefi et al.   PARASITOLOGY RESEARCH

Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression

(2017) Audrie A. Medina-Colorado et al.   PLoS One

Continual renewal and replication of persistentLeishmania majorparasites in concomitantly immune hosts

(2017) Michael A. Mandell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites

(2017) Alireza Badirzadeh et al.   PLoS Neglected Tropical Diseases

Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis

(2017) Alvaro J. Martínez-Valencia et al.   PLoS Neglected Tropical Diseases

CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

(2017) Fernanda O. Novais et al.   PLoS Pathogens

Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype

(2017) Fanping Kong et al.   PLoS Pathogens

Early Production of the Neutrophil-Derived Lipid Mediators LTB4 and LXA4 Is Modulated by Intracellular Infection with Leishmania major

(2017) Michael Plagge et al.   Biomed Research International

Apoptotic Cells Induced Signaling for Immune Homeostasis in Macrophages and Dendritic Cells

(2017) Uriel Trahtemberg et al.   Frontiers in Immunology

Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2A Receptor to Promote the Establishment of Infection

(2017) Mikhael H. F. Lima et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Reprogram IL-4/GM-CSF-Induced Monocyte Differentiation to Anti-inflammatory Macrophages

(2017) Anderson B. Guimarães-Costa et al.   Frontiers in Immunology

Function of Macrophage and Parasite Phosphatases in Leishmaniasis

(2017) Didier Soulat et al.   Frontiers in Immunology

Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani

(2017) Pablo Prieto Barja et al.   Nature Ecology & Evolution

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis

(2017) Karina Luiza Dias-Teixeira et al.   Scientific Reports

Mammalian Innate Immune Response to a Leishmania -Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence

(2016) Remzi Onur Eren et al.   Cell Host & Microbe

Leishmania-encoded orthologs of macrophage migration inhibitory factor regulate host immunity to promote parasite persistence

(2016) Thomas Holowka et al.   FASEB JOURNAL

The immunology of post-kala-azar dermal leishmaniasis (PKDL)

(2016) Eduard E. Zijlstra   Parasites & Vectors

Polarized M2 macrophages in dogs with visceral leishmaniasis

(2016) Pamela Rodrigues Reina Moreira et al.   VETERINARY PARASITOLOGY

Concomitant Immunity Induced by Persistent Leishmania major Does Not Preclude Secondary Re-Infection: Implications for Genetic Exchange, Diversity and Vaccination

(2016) Michael A. Mandell et al.   PLoS Neglected Tropical Diseases

Cutaneous Leishmaniasis Vaccination: A Matter of Quality

(2016) Paula Mello De Luca et al.   Frontiers in Immunology

The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis

(2016) Elisangela Oliveira de Freitas et al.   Frontiers in Immunology

The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis

(2016) Pedro Paulo Carneiro et al.   PLoS One

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

(2016) Annelies Mondelaers et al.   PLoS One

Apoptotic-likeLeishmaniaexploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination

(2015) Peter Crauwels et al.   Autophagy

Visceral Leishmaniasis/HIV co-infection in northeast Brazil: evaluation of outcome

(2015) Lara Gurgel Fernandes Távora et al.   Brazilian Journal of Infectious Diseases

Leishmania survival in the macrophage: where the ends justify the means

(2015) Guillermo Arango Duque et al.   CURRENT OPINION IN MICROBIOLOGY

Leishmania donovani: impairment of the cellular immune response against recombinant ornithine decarboxylase protein as a possible evasion strategy of Leishmania in visceral leishmaniasis

(2015) Anupam Yadav et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis

(2015) Mariana Rosales-Chilama et al.   PLoS Neglected Tropical Diseases

IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection

(2015) Akil Hammami et al.   PLoS Pathogens

Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis

(2015) Diana Moreira et al.   PLoS Pathogens

Are Neutrophil Extracellular Traps Playing a Role in the Parasite Control in Active American Tegumentary Leishmaniasis Lesions?

(2015) Fernanda Nazaré Morgado et al.   PLoS One

3′-Nucleotidase/Nuclease Activity Allows Leishmania Parasites To Escape Killing by Neutrophil Extracellular Traps

(2014) Anderson B. Guimarães-Costa et al.   INFECTION AND IMMUNITY

Protective and Pathological Functions of CD8+T Cells in Leishmania braziliensis Infection

(2014) Thiago Marconi Cardoso et al.   INFECTION AND IMMUNITY

Intermediate Monocytes Contribute to Pathologic Immune Response inLeishmania braziliensisInfections

(2014) Sara Passos et al.   JOURNAL OF INFECTIOUS DISEASES

SOD1 Plasma Level as a Biomarker for Therapeutic Failure in Cutaneous Leishmaniasis

(2014) Ricardo Khouri et al.   JOURNAL OF INFECTIOUS DISEASES

Essential role of leukotriene B4 on Leishmania (Viannia) braziliensis killing by human macrophages

(2014) Camila I. Morato et al.   MICROBES AND INFECTION

Prostaglandin E2/Leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection

(2014) Théo Araújo-Santos et al.   Parasites & Vectors

Lundep, a Sand Fly Salivary Endonuclease Increases Leishmania Parasite Survival in Neutrophils and Inhibits XIIa Contact Activation in Human Plasma

(2014) Andrezza C. Chagas et al.   PLoS Pathogens

Leishmania Evades Host Immunity by Inhibiting Antigen Cross-Presentation through Direct Cleavage of the SNARE VAMP8

(2013) Diana Matheoud et al.   Cell Host & Microbe

In vitro evaluation of 4-phenyl-5-(4′-X-phenyl)-1,3,4-thiadiazolium-2-phenylaminide chlorides and 3[N-4′-X-phenyl]-1,2,3-oxadiazolium-5-olate derivatives on nitric oxide synthase and arginase activities of Leishmania amazonensis

(2013) Romulo J. Soares-Bezerra et al.   EXPERIMENTAL PARASITOLOGY

Leishmania-Infected MHC Class IIhigh Dendritic Cells Polarize CD4+ T Cells toward a Nonprotective T-bet+ IFN- + IL-10+ Phenotype

(2013) M. Resende et al.   JOURNAL OF IMMUNOLOGY

Programmed Death 1-Mediated T Cell Exhaustion during Visceral Leishmaniasis Impairs Phagocyte Function

(2013) K. J. Esch et al.   JOURNAL OF IMMUNOLOGY

CD8 T Cell Exhaustion in Human Visceral Leishmaniasis

(2013) Shalini Gautam et al.   JOURNAL OF INFECTIOUS DISEASES

Two biochemically distinct lipophosphoglycans from Leishmania braziliensis and Leishmania infantum trigger different innate immune responses in murine macrophages

(2013) Izabela Coimbra Ibraim et al.   Parasites & Vectors

Reciprocal Regulation of Protein Kinase C Isoforms Results in Differential Cellular Responsiveness

(2012) R. Sudan et al.   JOURNAL OF IMMUNOLOGY

Visceral and post-Kala-Azar dermal leishmaniasis isolates show significant difference in their in vitro drug susceptibility pattern

(2012) Jyotsna Mishra et al.   PARASITOLOGY RESEARCH

Leishmania amazonensis Arginase Compartmentalization in the Glycosome Is Important for Parasite Infectivity

(2012) Maria Fernanda Laranjeira da Silva et al.   PLoS One

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Post-kala-azar dermal leishmaniasis in visceral leishmaniasis-endemic communities in Bihar, India

(2012) Rudra Pratap Singh et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Influence of apoptosis on the cutaneous and peripheral lymph node inflammatory response in dogs with visceral leishmaniasis

(2012) Pamela Rodrigues Reina Moreira et al.   VETERINARY PARASITOLOGY

Ecto-Nucleotidase Activities of Promastigotes from Leishmania (Viannia) braziliensis Relates to Parasite Infectivity and Disease Clinical Outcome

(2012) Pauline M. Leite et al.   PLoS Neglected Tropical Diseases

Comparative Study of rK39 Leishmania Antigen for Serodiagnosis of Visceral Leishmaniasis: Systematic Review with Meta-Analysis

(2012) Zuinara Maia et al.   PLoS Neglected Tropical Diseases

The influence of early neutrophil-Leishmania interactions on the host immune response to infection

(2012) Flavia L. Ribeiro-Gomes et al.   Frontiers in Cellular and Infection Microbiology

Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?

(2012) Lucio H. Freitas-Junior et al.   International Journal for Parasitology-Drugs and Drug Resistance

PD-1 Signaling in HIV and Chronic Viral Infection – Potential for Therapeutic Intervention?

(2011) Q. Eichbaum   CURRENT MEDICINAL CHEMISTRY

Leishmania major parasite stage-dependent host cell invasion and immune evasion

(2011) Ulf Alexander Wenzel et al.   FASEB JOURNAL

Activation of Phosphatidylinositol 3-Kinase/Akt and Impairment of Nuclear Factor-κB

(2010) Bruno Miguel Neves et al.   AMERICAN JOURNAL OF PATHOLOGY

Post-kala-azar dermal leishmaniasis - an overview

(2010) Sudipto Ganguly et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Viability and Burden of Leishmania in Extralesional Sites during Human Dermal Leishmaniasis

(2010) Ibeth Romero et al.   PLoS Neglected Tropical Diseases

The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis

(2009) Nathan C. Peters et al.   CELLULAR MICROBIOLOGY

NF-κB-mediated repression of iNOS expression in Leishmania amazonensis macrophage infection

(2009) Teresa C. Calegari-Silva et al.   IMMUNOLOGY LETTERS

Detection ofLeishmaniain Unaffected Mucosal Tissues of Patients with Cutaneous Leishmaniasis Caused byLeishmania (Viannia)Species

(2009) Roger Adrian Figueroa et al.   JOURNAL OF INFECTIOUS DISEASES

Signs of anin situinflammatory reaction in scars of human American tegumentary leishmaniasis

(2009) F. N. MORGADO et al.   PARASITE IMMUNOLOGY

Cooperation between Apoptotic and Viable Metacyclics Enhances the Pathogenesis of Leishmaniasis

(2009) João Luiz Mendes Wanderley et al.   PLoS One

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B7-H1 Blockade Increases Survival of Dysfunctional CD8+ T Cells and Confers Protection against Leishmania donovani Infections

(2009) Trupti Joshi et al.   PLoS Pathogens

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45−/− mice

(2008) Gerald F. Späth et al.   EXPERIMENTAL PARASITOLOGY

Persistent parasites and immunologic memory in cutaneous leishmaniasis: implications for vaccine designs and vaccination strategies

(2008) Ifeoma Okwor et al.   IMMUNOLOGIC RESEARCH

Neutrophil apoptosis and the resolution of infection

(2008) Adam D. Kennedy et al.   IMMUNOLOGIC RESEARCH

Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1)

(2008) Julie Blanchette et al.   IMMUNOLOGY

Meglumine antimonate directly increases phagocytosis, superoxide anion and TNF-α production, but only via TNF-α it indirectly increases nitric oxide production by phagocytes of healthy individuals, in vitro

(2008) Maria Imaculada Muniz-Junqueira et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis

(2008) Lilian Afonso et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In vitro infectivity of species of Leishmania (Viannia) responsible for American cutaneous leishmaniasis

(2008) Marliane Batista Campos et al.   PARASITOLOGY RESEARCH

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE

Immunity to Distinct Sand Fly Salivary Proteins Primes the Anti-Leishmania Immune Response towards Protection or Exacerbation of Disease

(2008) Fabiano Oliveira et al.   PLoS Neglected Tropical Diseases