Article
Microbiology
Laura Sanchez-Garcia, Armando Perez-Torres, Marco E. Gudino-Zayas, Jaime Zamora-Chimal, Claudio Meneses, Shaden Kamhawi, Jesus G. Valenzuela, Ingeborg Becker
Summary: Leishmania parasites infect mammalian hosts through sand fly bites. Mast cells (MC) were found at the bite sites of infected and non-infected sand flies, releasing granules with intense TNF-alpha, histamine, and tryptase staining. The number of MC was significantly higher in infected bites compared to non-infected bites or controls. Neutrophil recruitment was intense during the initial 6 hours and decreased thereafter, both in the skin and lymph nodes.
Review
Immunology
Matheus B. Carneiro, Nathan C. Peters
Summary: This review focuses on the interaction between Leishmania amazonensis infection and host innate immune response, particularly addressing the impact of adaptive immunity on phagocytic host cell recruitment and activation. Experimental observations indicate that most mouse strains are susceptible to L. amazonensis infection, unlike other Leishmania species. The CD4(+) T helper (Th)1/Th2 paradigm does not fully explain the chronic disease established by L. amazonensis, with recent findings complicating the understanding of the Th1/Th2 paradigm.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Weicai Huang, Yuming Jiang, Wenjun Xiong, Zepang Sun, Chuanli Chen, Qingyu Yuan, Kangneng Zhou, Zhen Han, Hao Feng, Hao Chen, Xiaokun Liang, Shitong Yu, Yanfeng Hu, Jiang Yu, Yan Chen, Liying Zhao, Hao Liu, Zhiwei Zhou, Wei Wang, Yikai Xu, Guoxin Li
Summary: In this study, the authors used CT-based radiomics to predict the response to immunotherapy in gastric cancer patients, and found that radiomics imaging biomarker is closely associated with tumor immune microenvironment and may correlate with prognosis and response to anti PD-1 immunotherapy.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Qifeng Ou, Rachael Power, Matthew D. Griffin
Summary: Regulatory T cells (Treg) play a critical role in maintaining immune homeostasis and have direct modulatory effects on innate immune responses in various acute and chronic diseases. Therapeutic interventions aimed at enhancing Treg numbers or potency show promising outcomes in autoimmunity and allogeneic transplants. Furthermore, interactions between Treg and innate immune effectors significantly impact disease severity and treatment. Treg-based therapeutic strategies hold potential for globally impactful inflammatory conditions such as type 2 diabetes, ischemia reperfusion injury, and atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Lais Morandini, Derek Avery, Benjamin Angeles, Paul Winston, Rebecca K. Martin, Henry J. Donahue, Rene Olivares-Navarrete
Summary: Neutrophils play a crucial role in the immune response to biomaterial implantation by releasing cytokines, chemokines, and DNA-based networks called NETs. In this study, we found that inhibiting NET formation suppresses pro-inflammatory macrophage activation and accelerates the inflammatory phase of healing, leading to greater bone formation around the implanted biomaterial. These findings highlight the importance of the neutrophil response and innate immune cell regulation during the integration of biomaterials.
ACTA BIOMATERIALIA
(2023)
Article
Immunology
Patrick P. G. Mulder, Marcel Vlig, Esther Fasse, Matthea M. Stoop, Anouk Pijpe, Paul P. M. van Zuijlen, Irma Joosten, Bouke K. H. L. Boekema, Hans J. P. M. Koenen
Summary: The immune response in burn patients is often extreme and abnormal. Understanding the immune effects of thermal injury is necessary to improve patient outcomes. This study shows that after burn injury, immune cells persistently increase in number, unlike in normal wound healing. The study also reveals high levels of chemokines and pro-inflammatory cytokines in burn tissue. The local immune response in burns is similar to the systemic immune reaction, but differs in neutrophil maturity and lymphocyte composition.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ioannis Mitroulis, Akrivi Chrysanthopoulou, Georgios Divolis, Charalampos Ioannidis, Maria Ntinopoulou, Athanasios Tasis, Theocharis Konstantinidis, Christina Antoniadou, Natalia Soteriou, George Lallas, Stella Mitka, Mathias Lesche, Andreas Dahl, Stephanie Gembardt, Maria Panopoulou, Paschalis Sideras, Ben Wielockx, Uenal Coskun, Konstantinos Ritis, Panagiotis Skendros
Summary: This study provides an in-depth analysis of the transcriptomic alterations that occur in human phagocytes upon infection and in peripheral blood immune populations during active brucellosis. It reveals molecular changes related to the disease progression and treatment response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
N. Fine, J. W. Chadwick, C. Sun, K. K. Parbhakar, N. Khoury, A. Barbour, M. Goldberg, H. C. Tenenbaum, M. Glogauer
Summary: The presence of periodontal diseases is closely related to other chronic inflammatory conditions such as cardiovascular disease, diabetes, and arthritis. Studies show that periodontal tissue inflammation affects the production and activation of polymorphonuclear neutrophils (PMNs), contributing to a hyperinflammatory response in the body. This systemic effect of PD on immune response can exacerbate inflammatory reactions when faced with secondary infections, highlighting the complex interactions between PD and other inflammatory diseases.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Immunology
Haifa Bichiou, Cyrine Bouabid, Imen Rabhi, Lamia Guizani-Tabbane
Summary: Leishmaniasis is a group of diseases caused by over 20 parasite species of the protozoa belonging to the Leishmania genus, spread by sandfly bites. Depending on the immune status of the host and the parasite species, it can present a wide range of clinical manifestations. Transcription factors play a key role in regulating the immune-metabolic responses and the host's reaction against the parasite.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Sajida Malik, Hao Wang, Soniya Xavier, Mary Slayo, Steve Bozinovski, Luba Sominsky, Sarah J. Spencer
Summary: The study shows that immune response can still occur in the absence of microglia and monocytes, but it is exacerbated and prolonged due to excessive neutrophil response in peripheral organs.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Biology
Ryuji Yanase, Flavia Moreira-Leite, Edward Rea, Lauren Wilburn, Jovana Sadlova, Barbora Vojtkova, Katerina Pruzinova, Atsushi Taniguchi, Shigenori Nonaka, Petr Volf, Jack D. Sunter
Summary: Attachment to a substrate is a common strategy among eukaryotic parasites for maintaining position in a specific ecological niche. In this study, the researchers used advanced electron microscopy techniques to investigate the adhesion of Leishmania parasites to the stomodeal valve in the sand fly vector. They found distinct structural elements in the attachment plaque and identified five stages of haptomonad-like cell differentiation. The study also demonstrated the importance of calcium for Leishmania adhesion in vitro. These findings provide important insights into the structural and regulatory aspects of Leishmania adhesion and contribute to a better understanding of its life cycle.
Article
Engineering, Biomedical
Derek Avery, Lais Morandini, Natalie Celt, Leah Bergey, Jamelle Simmons, Rebecca K. Martin, Henry J. Donahue, Rene Olivares-Navarrete
Summary: This study evaluates the response of inflammatory and immune cells to four common orthopedic materials (pure titanium, titanium alloy, 316L stainless steel, PEEK). The results show that PEEK and stainless steel induce a stronger inflammatory response compared to titanium or titanium alloy, characterized by high infiltration of neutrophils and T cells. The chemical composition of the biomaterials plays a crucial role in the immune cell response.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Aoife B. Kilgallen, Frederieke van den Akker, Dries A. M. Feyen, Sandra Crnko, Christian J. B. Snijders Blok, Hendrik Gremmels, Bastiaan C. du Pre, Robin Reijers, Pieter A. Doevendans, Saskia C. A. de Jager, Joost P. G. Sluijter, Vasco Sampaio-Pinto, Linda W. van Laake
Summary: Circadian rhythms play a crucial role in the hyperacute immune response after a myocardial infarction (MI). The levels of immune cells and cardiac damage vary throughout the day, indicating the circadian influence on the immune response. These findings align with the clinical observation that patients who experience an MI early in the morning have worse outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Michael Mihlan, Shima Safaiyan, Manuel Stecher, Neil Paterson, Tim Laemmermann
Summary: Successful immune responses rely on the coordinated migration, interactions, and functioning of immune cells in lymphoid and parenchymal tissues. Real-time intravital microscopy has provided insights into the dynamic behavior of immune cells in living tissues, revealing unexpected biological features that were not observed in experiments outside of a living organism.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
F. L. Ribeiro-Gomes, A. Romano, S. Lee, E. Roffe, N. C. Peters, A. Debrabant, D. Sacks
CELL DEATH & DISEASE
(2015)
Article
Immunology
Melanie Charmoy, Benjamin P. Hurrell, Audrey Romano, Sang Hun Lee, Flavia Ribeiro-Gomes, Nicolas Riteau, Katrin Mayer-Barber, Fabienne Tacchini-Cottier, David L. Sacks
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Microbiology
Audrey Romano, Matheus B. H. Carneiro, Nicole A. Doria, Eric H. Roma, Flavia L. Ribeiro-Gomes, Ehud Inbar, Sang Hun Lee, Jonatan Mendez, Andrea Paun, David L. Sacks, Nathan C. Peters
Article
Immunology
Natalia S. Vellozo, Samara T. Pereira-Marques, Mariela P. Cabral-Piccin, Alessandra A. Filardy, Flavia L. Ribeiro-Gomes, Thais S. Rigoni, George A. DosReis, Marcela F. Lopes
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Parasitology
Luciana Pereira de Sousa, Roberto Farina de Almeida, Flavia Lima Ribeiro-Gomes, Leonardo Jose de Moura Carvalho, Tadeu Mello e Souza, Diogo Onofre Gomes de Souza, Claudio Tadeu Daniel-Ribeiro
PARASITES & VECTORS
(2018)
Article
Immunology
Flavia L. Ribeiro-Gomes, Eric Henrique Roma, Matheus B. H. Carneiro, Nicole A. Doria, David L. Sacks, Nathan C. Peters
INFECTION AND IMMUNITY
(2014)
Article
Immunology
Helton da Costa Santiago, Flavia L. Ribeiro-Gomes, Sasisekhar Bennuru, Thomas B. Nutman
JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
Monica Losada-Barragan, Adriana Umana-Perez, Jonathan Duraes, Sergio Cuervo-Escobar, Andres Rodriguez-Vega, Flavia L. Ribeiro-Gomes, Luiz R. Berbert, Fernanda Morgado, Renato Porrozzi, Daniella Areas Mendes-da-Cruz, Priscila Aquino, Paulo C. Carvalho, Wilson Savino, Myriam Sanchez-Gomez, Gabriel Padron, Patricia Cuervo
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Saba Gul, Flavia L. Ribeiro-Gomes, Aline S. Moreira, Guilherme S. Sanches, Fabiana G. Conceicao, Claudio Tadeu Daniel-Ribeiro, Hans C. Ackerman, Leonardo J. M. Carvalho
Summary: The study showed that whole blood transfusion can effectively prevent further drop in hematocrit and partially restore platelet count after artemether treatment, and alleviate spleen congestion. Transfusion restored plasma Ang-2 level to quiescence, while Ang-1 in ECM mice could not be replenished by any treatment.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Luciana Pereira de Sousa, Flavia Lima Ribeiro-Gomes, Roberto Farina de Almeida, Tadeu Mello e Souza, Guilherme Loureiro Werneck, Diogo Onofre Souza, Claudio Tadeu Daniel-Ribeiro
Summary: Research shows that immune modulation induced by specific immune stimuli can enhance recognition memory in mice and reverse memory impairment and anxiety caused by mild malaria infection.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Pamela Rosa-Goncalves, Flavia Lima Ribeiro-Gomes, Claudio Tadeu Daniel-Ribeiro
Summary: Malaria, caused by the protozoa Plasmodium, is a significant public health issue in tropical and subtropical regions. The disease can present with a range of symptoms, with cerebral malaria being the most severe and lethal complication. Survivors of cerebral malaria may experience neurological, cognitive, and behavioral sequelae. Recent studies suggest immunomodulation as a potential approach to prevent or reverse these neurocognitive sequelae of malaria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Pamela Rosa-Goncalves, Luciana Pereira de Sousa, Aline Barbosa Maia, Flavia Lima Ribeiro-Gomes, Caroline Cristhiani Tavares de Lima Gress, Guilherme Loureiro Werneck, Diogo Onofre Souza, Roberto Farina Almeida, Claudio Tadeu Daniel-Ribeiro
Summary: The study suggests that immunization with immunogens that induce type 2 immune responses may reverse cognitive and behavioral impairments associated with malaria. This finding highlights the potential importance of researching and developing vaccines for the treatment and prevention of post-malaria sequelae.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pamela Rosa-Goncalves, Luciana Pereira de Sousa, Flavia Lima Ribeiro-Gomes, Leonardo Jose Moura Carvalho, Claudio Tadeu Daniel-Ribeiro
Summary: Malaria, caused by protozoa of the genus Plasmodium, is an ancient parasitic disease characterized by fever, headache, sweating, and chills. Neurological, neurocognitive, and behavioral alterations, as well as poor school performance, can develop in survivors. Neuroinflammation plays a crucial role in the cognitive dysfunctions associated with malaria. Vaccination with type 2 immune response elicitors, such as the tetanus-diphtheria vaccine, may have a beneficial effect in alleviating neuroinflammation and mitigating neurocognitive deficits.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Immunology
Uyla Ornellas-Garcia, Patricia Cuervo, Flavia Lima Ribeiro-Gomes
Summary: Malaria and leishmaniasis are endemic parasitic diseases in tropical and subtropical countries. Co-infection with Plasmodium spp. and Leishmania spp. can either exacerbate or suppress the immune response, impacting the clinical course and management of these diseases. Addressing the importance of concomitant infections is crucial for accurate diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Parasitology
Yuri Chaves Martins, Flavia Lima Ribeiro-Gomes, Claudio Tadeu Daniel-Ribeiro
Summary: Innate immunity is the first line of defense against pathogens, cancer cells, and toxins. It also plays a crucial role in activating the body's specific immune response. This overview highlights the key findings and ideas that have contributed to the development of innate immunity as a branch of modern immunology.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)
