CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

Neutrophil heterogeneity: implications for homeostasis and pathogenesis

(2016) C. Silvestre-Roig et al.   BLOOD

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice

(2016) Melanie Charmoy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An NLRP3 inflammasome–triggered Th2-biased adaptive immune response promotes leishmaniasis

(2015) Prajwal Gurung et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+T Cells That Exacerbates Disease in Mice Coinfected withLeishmania major

(2015) Erika J. Crosby et al.   JOURNAL OF IMMUNOLOGY

Genomic Profiling of Human Leishmania braziliensis Lesions Identifies Transcriptional Modules Associated with Cutaneous Immunopathology

(2015) Fernanda O. Novais et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications

(2015) Christian Herder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8+ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling

(2015) F L Ribeiro-Gomes et al.   Cell Death & Disease

The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia

(2015) Jie Liao et al.   Nature Communications

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

Inflammasome activation in response to dead cells and their metabolites

(2014) Hajime Kono et al.   CURRENT OPINION IN IMMUNOLOGY

Protective and Pathological Functions of CD8+T Cells in Leishmania braziliensis Infection

(2014) Thiago Marconi Cardoso et al.   INFECTION AND IMMUNITY

Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease

(2014) Giovane Rodrigo Sousa et al.   PLoS One

Engagement of NKG2D on Bystander Memory CD8 T Cells Promotes Increased Immunopathology following Leishmania major Infection

(2014) Erika J. Crosby et al.   PLoS Pathogens

Successful therapy with anakinra in a patient with generalized pustular psoriasis carryingIL36RNmutations

(2013) U. Hüffmeier et al.   BRITISH JOURNAL OF DERMATOLOGY

Cytotoxic and Proinflammatory CD8 + T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice

(2013) Tin Kyaw et al.   CIRCULATION

CD8+ Granzyme B+–Mediated Tissue Injury vs. CD4+IFNγ+–Mediated Parasite Killing in Human Cutaneous Leishmaniasis

(2013) Claire da Silva Santos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

(2013) Djalma S Lima-Junior et al.   NATURE MEDICINE

Cytotoxic T Cells Mediate Pathology and Metastasis in Cutaneous Leishmaniasis

(2013) Fernanda O. Novais et al.   PLoS Pathogens

IL-1 Receptor Signaling Is Required at Multiple Stages of Sensitization and Elicitation of the Contact Hypersensitivity Response

(2012) D. D. Kish et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Serine Proteases Promote IL-1  Generation and Injury in Necrotizing Crescentic Glomerulonephritis

(2012) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Compartmentalized Control of Skin Immunity by Resident Commensals

(2012) S. Naik et al.   SCIENCE

Disease Severity in Patients Infected with Leishmania mexicana Relates to IL-1β

(2012) Edith A. Fernández-Figueroa et al.   PLoS Neglected Tropical Diseases

Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice

(2012) John S. Cho et al.   PLoS Pathogens

CD8+ T-Cells Expressing Interferon Gamma or Perforin Play Antagonistic Roles in Heart Injury in Experimental Trypanosoma Cruzi-Elicited Cardiomyopathy

(2012) Jaline Coutinho Silverio et al.   PLoS Pathogens

Protective and pathologic immune responses in human tegumentary leishmaniasis

(2012) Lucas P. Carvalho et al.   Frontiers in Immunology

Granzyme B Expression by CD8+ T Cells Is Required for the Development of Experimental Cerebral Malaria

(2011) A. Haque et al.   JOURNAL OF IMMUNOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

(2010) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

The NLRP3 inflammasome, a target for therapy in diverse disease states

(2010) Graham P. Cook et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice

(2010) Kordula Kautz-Neu et al.   EXPERIMENTAL DERMATOLOGY

Neutrophils Reduce the Parasite Burden in Leishmania (Leishmania) amazonensis-Infected Macrophages

(2010) Érico Vinícius de Souza Carmo et al.   PLoS One

Prosurvival activity for airway neutrophils in severe asthma

(2010) M. Uddin et al.   THORAX

In vitrodetection of cytotoxic T and NK cells in peripheral blood of patients with various drug-induced skin diseases

(2009) A. Zawodniak et al.   ALLERGY

Plasma granzyme B as a predicting factor of coronary artery disease—Clinical significance in patients with chronic renal failure

(2009) Tomokazu Ikemoto et al.   Journal of Cardiology

Neutrophils and Macrophages Cooperate in Host Resistance against Leishmania braziliensis Infection

(2009) F. O. Novais et al.   JOURNAL OF IMMUNOLOGY

Recruitment of CD8+T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis

(2009) D. R. FARIA et al.   PARASITE IMMUNOLOGY

Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis

(2008) Lilian Afonso et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased granzyme B production from peripheral blood mononuclear cells in patients with acute coronary syndrome

(2007) R Tsuru et al.   HEART