Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype
Authors
Keywords
Macrophages, Spleen, Hamsters, Leishmaniasis, Parasitic diseases, Gene expression, Leishmania donovani, Interferons
Journal
PLoS Pathogens
Volume 13, Issue 1, Pages e1006165
Publisher
Public Library of Science (PLoS)
Online
2017-02-01
DOI
10.1371/journal.ppat.1006165
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Transcriptional regulation of myeloid-derived suppressor cells
- (2015) Thomas Condamine et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Leishmania infantum Amastigotes Trigger a Subpopulation of Human B Cells with an Immunoregulatory Phenotype
- (2015) Guadalupe Andreani et al. PLoS Neglected Tropical Diseases
- Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes
- (2014) Claudia M Espitia et al. BMC IMMUNOLOGY
- The role of indoleamine 2,3-dioxygenase (IDO) in immune tolerance: Focus on macrophage polarization of THP-1 cells
- (2014) Xian-Feng Wang et al. CELLULAR IMMUNOLOGY
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage
- (2014) G. Chan et al. JOURNAL OF IMMUNOLOGY
- Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing inMycobacterium tuberculosis–Infected Macrophages
- (2014) Finlay W. McNab et al. JOURNAL OF IMMUNOLOGY
- Leishmania Specific CD4 T Cells Release IFNγ That Limits Parasite Replication in Patients with Visceral Leishmaniasis
- (2014) Rajiv Kumar et al. PLoS Neglected Tropical Diseases
- Growth Factor and Th2 Cytokine Signaling Pathways Converge at STAT6 to Promote Arginase Expression in Progressive Experimental Visceral Leishmaniasis
- (2014) E. Yaneth Osorio et al. PLoS Pathogens
- Brain transcriptome sequencing and assembly of three songbird model systems for the study of social behavior
- (2014) Christopher N. Balakrishnan et al. PeerJ
- BRANCH: boosting RNA-Seq assemblies with partial or related genomic sequences
- (2013) Ergude Bao et al. BIOINFORMATICS
- Single-molecule fluorescence in situ hybridization: Quantitative imaging of single RNA molecules
- (2013) Sunjong Kwon BMB Reports
- Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes
- (2013) Heidi Dalrymple et al. BMC IMMUNOLOGY
- Indoleamine 2,3-dioxygenase activity as a potential biomarker of immune suppression during visceral leishmaniasis
- (2013) Jean-Pierre Gangneux et al. Innate Immunity
- Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii
- (2013) Veerupaxagouda Patil et al. INTERNATIONAL JOURNAL FOR PARASITOLOGY
- Immune Responsive Gene 1 (IRG1) Promotes Endotoxin Tolerance by Increasing A20 Expression in Macrophages through Reactive Oxygen Species
- (2013) Yingke Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer
- (2013) J. Yu et al. JOURNAL OF IMMUNOLOGY
- CD8 T Cell Exhaustion in Human Visceral Leishmaniasis
- (2013) Shalini Gautam et al. JOURNAL OF INFECTIOUS DISEASES
- Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF- B and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection
- (2013) J. Brownell et al. JOURNAL OF VIROLOGY
- Type I Interferon Suppresses Type II Interferon-Triggered Human Anti-Mycobacterial Responses
- (2013) R. M. B. Teles et al. SCIENCE
- Arginase Activity - A Marker of Disease Status in Patients with Visceral Leishmaniasis in Ethiopia
- (2013) Tamrat Abebe et al. PLoS Neglected Tropical Diseases
- Reassessment of Immune Correlates in Human Visceral Leishmaniasis as Defined by Cytokine Release in Whole Blood
- (2012) Om Prakash Singh et al. Clinical and Vaccine Immunology
- Transcriptome Analysis of a North American Songbird, Melospiza melodia
- (2012) A. Srivastava et al. DNA RESEARCH
- Marginal Zone B Cells Regulate Antigen-Specific T Cell Responses during Infection
- (2012) R. Bankoti et al. JOURNAL OF IMMUNOLOGY
- Identification of hamster inducible nitric oxide synthase (iNOS ) promoter sequences that influence basal and inducible iNOS expression
- (2012) Omar A. Saldarriaga et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Differential analysis of gene regulation at transcript resolution with RNA-seq
- (2012) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Indoleamine 2,3-dioxygenase (IDO) induced byLeishmaniainfection of human dendritic cells
- (2012) M. J. DONOVAN et al. PARASITE IMMUNOLOGY
- Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis
- (2012) Lynn Soong et al. Seminars in Immunopathology
- Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections
- (2012) Takayuki Matsumura et al. Nature Communications
- Local Increase of Arginase Activity in Lesions of Patients with Cutaneous Leishmaniasis in Ethiopia
- (2012) Tamrat Abebe et al. PLoS Neglected Tropical Diseases
- Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression
- (2012) E. Yaneth Osorio et al. PLoS Pathogens
- Chinese hamster genome database: An online resource for the CHO community at www.CHOgenome.org
- (2011) Stephanie Hammond et al. BIOTECHNOLOGY AND BIOENGINEERING
- Characterisation of the transcriptome of a wild great tit Parus major population by next generation sequencing
- (2011) Anna W Santure et al. BMC GENOMICS
- IRF7: activation, regulation, modification and function
- (2011) S Ning et al. GENES AND IMMUNITY
- Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance
- (2011) T. Downing et al. GENOME RESEARCH
- Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens
- (2011) Joshua C. Cyktor et al. INFECTION AND IMMUNITY
- IL-27 and IL-21 Are Associated with T Cell IL-10 Responses in Human Visceral Leishmaniasis
- (2011) Nasim Akhtar Ansari et al. JOURNAL OF IMMUNOLOGY
- Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression
- (2011) Levi H. C. Makala et al. JOURNAL OF INFECTIOUS DISEASES
- IL-10 Neutralization Promotes Parasite Clearance in Splenic Aspirate Cells From Patients With Visceral Leishmaniasis
- (2011) Shalini Gautam et al. JOURNAL OF INFECTIOUS DISEASES
- Full-length transcriptome assembly from RNA-Seq data without a reference genome
- (2011) Manfred G Grabherr et al. NATURE BIOTECHNOLOGY
- Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System
- (2011) Yaneth Osorio et al. PLoS Neglected Tropical Diseases
- Restoration of IFNγR Subunit Assembly, IFNγ Signaling and Parasite Clearance in Leishmania donovani Infected Macrophages: Role of Membrane Cholesterol
- (2011) Subha Sen et al. PLoS Pathogens
- Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2
- (2010) Alexandra Kadl et al. CIRCULATION RESEARCH
- Myeloid-derived suppressor cell heterogeneity and subset definition
- (2010) Elisa Peranzoni et al. CURRENT OPINION IN IMMUNOLOGY
- Murine visceral leishmaniasis: IgM and polyclonal B-cell activation lead to disease exacerbation
- (2010) Eszter Deak et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Interferon Regulatory Factor 7 Contributes to the Control ofLeishmania donovaniin the Mouse Liver
- (2010) Lynette Beattie et al. INFECTION AND IMMUNITY
- Mechanism of T Cell Tolerance Induced by Myeloid-Derived Suppressor Cells
- (2010) S. Nagaraj et al. JOURNAL OF IMMUNOLOGY
- Stromal Cell-Derived CXCL12 and CCL8 Cooperate To Support Increased Development of Regulatory Dendritic Cells Following Leishmania Infection
- (2010) A. T. Nguyen Hoang et al. JOURNAL OF IMMUNOLOGY
- The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
- (2010) Takashi Satoh et al. NATURE IMMUNOLOGY
- Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver
- (2010) C. H. Osterreicher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections
- (2010) Manira Rayamajhi et al. Virulence
- Differential expression analysis for sequence count data
- (2010) Simon Anders et al. GENOME BIOLOGY
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization
- (2009) Hernan Roca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-21 Mediates Suppressive Effects via Its Induction of IL-10
- (2009) R. Spolski et al. JOURNAL OF IMMUNOLOGY
- Autocrine IL-10 Induces Hallmarks of Alternative Activation in Macrophages and Suppresses Antituberculosis Effector Mechanisms without Compromising T Cell Immunity
- (2009) T. Schreiber et al. JOURNAL OF IMMUNOLOGY
- IFN- Impairs Superoxide-Dependent Parasite Killing in Human Macrophages: Evidence for a Deleterious Role of SOD1 in Cutaneous Leishmaniasis
- (2009) R. Khouri et al. JOURNAL OF IMMUNOLOGY
- Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis
- (2009) Manuel Modolell et al. PLoS Neglected Tropical Diseases
- Cytokine Signaling Modules in Inflammatory Responses
- (2008) John J. O'Shea et al. IMMUNITY
- Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
- (2008) Jessica B. Katz et al. IMMUNOLOGICAL REVIEWS
- Type I Interferon Signaling Exacerbates Chlamydia muridarum Genital Infection in a Murine Model
- (2008) U. M. Nagarajan et al. INFECTION AND IMMUNITY
- RNA-Seq: a revolutionary tool for transcriptomics
- (2008) Zhong Wang et al. NATURE REVIEWS GENETICS
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started