Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis

Real-time 3D visualization of cellular rearrangements during cardiac valve formation

(2016) Jenny Pestel et al.   DEVELOPMENT

The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

(2016) Timm Haack et al.   DEVELOPMENT

Biomechanics of vascular mechanosensation and remodeling

(2016) Nicolas Baeyens et al.   MOLECULAR BIOLOGY OF THE CELL

Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

(2016) Zinan Zhou et al.   NATURE

klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis

(2016) Emily Steed et al.   Nature Communications

Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development

(2015) Emilie Heckel et al.   CURRENT BIOLOGY

The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression

(2015) Zinan Zhou et al.   DEVELOPMENTAL CELL

Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins

(2015) Marc Renz et al.   DEVELOPMENTAL CELL

The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3

(2015) Xavier Cullere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events

(2014) Rachael A McCloy et al.   CELL CYCLE

Cerebral Cavernous Malformations Arise Independent of the Heart of Glass Receptor

(2014) Xiangjian Zheng et al.   STROKE

CCM proteins control endothelial  1 integrin dependent response to shear stress

(2014) Z. Macek Jilkova et al.   Biology Open

The Krüppel-like factor 2 and Krüppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis

(2013) Aditi R Chiplunkar et al.   BMC DEVELOPMENTAL BIOLOGY

CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling

(2013) Eva Faurobert et al.   JOURNAL OF CELL BIOLOGY

Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations

(2013) Chao You et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors

(2012) N. Ninov et al.   DEVELOPMENT

Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

(2012) Alexandre R. Gingras et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

MEK5/ERK5 pathway: The first fifteen years

(2011) Barbara A. Drew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production

(2011) Anne Karine Lagendijk et al.   CIRCULATION RESEARCH

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

(2011) Bilge Yoruk et al.   DEVELOPMENTAL BIOLOGY

Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes

(2011) Anya Sedletcaia et al.   DEVELOPMENTAL DYNAMICS

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

(2011) Aubrey C. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice

(2011) Gwénola Boulday et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recent insights into cerebral cavernous malformations: the molecular genetics of CCM

(2010) Florence Riant et al.   FEBS Journal

CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

(2010) Xiangjian Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis

(2010) Stefania Nicoli et al.   NATURE

Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale

(2010) Beth A. Rose et al.   PHYSIOLOGICAL REVIEWS

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

(2010) Joycelyn Wüstehube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway

(2009) Benjamin Kleaveland et al.   NATURE MEDICINE

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart

(2009) Julien Vermot et al.   PLOS BIOLOGY

High-speed imaging of developing heart valves reveals interplay of morphogenesis and function

(2008) P. J. Scherz et al.   DEVELOPMENT

Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo

(2008) Yannick Blum et al.   DEVELOPMENTAL BIOLOGY