Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

Allosteric Optical Control of a Class B G-Protein-Coupled Receptor

(2016) Johannes Broichhagen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Impact, determination and prediction of drug–receptor residence times for GPCRs

(2016) Christofer S Tautermann   CURRENT OPINION IN PHARMACOLOGY

Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles

(2016) Ana B. Bueno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant

(2016) Wilhelmus E.A. de Witte et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Added Value of Assessing Ligand–Receptor Binding Kinetics in Drug Discovery

(2016) Dong Guo et al.   ACS Medicinal Chemistry Letters

The role of kinetic context in apparent biased agonism at GPCRs

(2016) Carmen Klein Herenbrink et al.   Nature Communications

A Roadmap to Success in Photopharmacology

(2015) Johannes Broichhagen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Allosteric Modulation of M1Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking

(2014) Holly R. Yeatman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification

(2014) Whitney M Nolte et al.   Nature Chemical Biology

Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells

(2013) Ramya S. Kuna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Minireview: Signal Bias, Allosterism, and Polymorphic Variation at the GLP-1R: Implications for Drug Discovery

(2013) Cassandra Koole et al.   MOLECULAR ENDOCRINOLOGY

Time-resolved fluorescence ligand binding for G protein–coupled receptors

(2013) Alexander Emami-Nemini et al.   Nature Protocols

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

(2011) Colin A. Leech et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

(2009) Candice E. Paulsen et al.   ACS Chemical Biology

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY