Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol

GPCR Dynamics: Structures in Motion

(2016) Naomi R. Latorraca et al.   CHEMICAL REVIEWS

Cis and trans unsaturated phosphatidylcholine bilayers: A molecular dynamics simulation study

(2016) Waldemar Kulig et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Interaction of G protein coupled receptors and cholesterol

(2016) Gerald Gimpl   CHEMISTRY AND PHYSICS OF LIPIDS

Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer

(2016) Marina Casiraghi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Experimental determination and computational interpretation of biophysical properties of lipid bilayers enriched by cholesteryl hemisuccinate

(2015) Waldemar Kulig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Can Specific Protein-Lipid Interactions Stabilize an Active State of the Beta 2 Adrenergic Receptor?

(2015) Chris Neale et al.   BIOPHYSICAL JOURNAL

Cholesterol under oxidative stress—How lipid membranes sense oxidation as cholesterol is being replaced by oxysterols

(2015) Waldemar Kulig et al.   FREE RADICAL BIOLOGY AND MEDICINE

How To Minimize Artifacts in Atomistic Simulations of Membrane Proteins, Whose Crystal Structure Is Heavily Engineered: β2-Adrenergic Receptor in the Spotlight

(2015) Moutusi Manna et al.   Journal of Chemical Theory and Computation

Allosteric regulation of G protein–coupled receptor activity by phospholipids

(2015) Rosie Dawaliby et al.   Nature Chemical Biology

Cholesterol Modulates the Dimer Interface of the β2-Adrenergic Receptor via Cholesterol Occupancy Sites

(2014) Xavier Prasanna et al.   BIOPHYSICAL JOURNAL

Two Classes of Cholesterol Binding Sites for the β 2 AR Revealed by Thermostability and NMR

(2014) Deborah L. Gater et al.   BIOPHYSICAL JOURNAL

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

(2014) Aashish Manglik et al.   CURRENT OPINION IN CELL BIOLOGY

Universal Method for Embedding Proteins into Complex Lipid Bilayers for Molecular Dynamics Simulations

(2014) Matti Javanainen   Journal of Chemical Theory and Computation

How well does cholesteryl hemisuccinate mimic cholesterol in saturated phospholipid bilayers?

(2014) Waldemar Kulig et al.   JOURNAL OF MOLECULAR MODELING

Refined OPLS All-Atom Force Field for Saturated Phosphatidylcholine Bilayers at Full Hydration

(2014) Arkadiusz Maciejewski et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Enzymatic Oxidation of Cholesterol: Properties and Functional Effects of Cholestenone in Cell Membranes

(2014) Maarit Neuvonen et al.   PLoS One

Membrane proteins, detergents and crystals: what is the state of the art?

(2014) Patrick J. Loll   Acta Crystallographica Section F-Structural Biology Communications

The Structural Basis of G-Protein-Coupled Receptor Signaling (Nobel Lecture)

(2013) Brian Kobilka   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereospecific requirement of cholesterol in the function of the serotonin1A receptor

(2013) Md. Jafurulla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Computational analysis of local membrane properties

(2013) Vytautas Gapsys et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Mapping the Functional Binding Sites of Cholesterol in β2-Adrenergic Receptor by Long-Time Molecular Dynamics Simulations

(2013) Xiaohui Cang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Evidence for Cardiolipin Binding Sites on the Membrane-Exposed Surface of the Cytochrome bc1

(2013) Clement Arnarez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PhylomeDB v4: zooming into the plurality of evolutionary histories of a genome

(2013) Jaime Huerta-Cepas et al.   NUCLEIC ACIDS RESEARCH

Effect of intracellular loop 3 on intrinsic dynamics of human β2-adrenergic receptor

(2013) Ozer Ozcan et al.   BMC STRUCTURAL BIOLOGY

Predictions for Cholesterol Interaction Sites on the A2A Adenosine Receptor

(2012) Ji Young Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

Cholesterol increases kinetic, energetic, and mechanical stability of the human  2-adrenergic receptor

(2012) M. Zocher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Cholesterol-induced conformational changes in the oxytocin receptor

(2011) Sabine Muth et al.   BIOCHEMICAL JOURNAL

Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

(2011) Joanne Oates et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

(2011) Tony Warne et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Cholesterol driven alteration of the conformation and dynamics of phospholamban in model membranes

(2011) Moutusi Manna et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Regulation of human EGF receptor by lipids

(2011) U. Coskun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation mechanism of the  2-adrenergic receptor

(2011) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol depletion enhances adrenergic signaling in cardiac myocytes

(2010) Yamuna Devi Paila et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Interactions of oxysterols with membranes and proteins

(2009) Vesa M. Olkkonen et al.   MOLECULAR ASPECTS OF MEDICINE

Identification of two distinct inactive conformations of the  2-adrenergic receptor reconciles structural and biochemical observations

(2009) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The function of G-protein coupled receptors and membrane cholesterol: specific or general interaction?

(2008) Yamuna Devi Paila et al.   GLYCOCONJUGATE JOURNAL

Cholesterol-dependent Separation of the β2-Adrenergic Receptor from Its Partners Determines Signaling Efficacy

(2008) Stéphanie M. Pontier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE