A Pilot Microbiota Study in Parkinson’s Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models

Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice

(2019) Chrissa Petersen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

FTY720 Improves Behavior, Increases Brain Derived Neurotrophic Factor and Reduces α-Synuclein Pathology in Parkinsonian GM2 +/− Mice

(2019) Guadalupe Vidal-Martinez et al.   NEUROSCIENCE

FTY720-Mitoxy reduces toxicity associated with MSA-like α-synuclein and oxidative stress by increasing trophic factor expression and myelin protein in OLN-93 oligodendroglia cell cultures

(2019) Javier Vargas-Medrano et al.   NEUROPHARMACOLOGY

Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota

(2018) Cynthia Reinoso Webb et al.   INFLAMMATORY BOWEL DISEASES

Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases

(2018) Sara Gerhardt et al.   Nutrients

Extensive impact of non-antibiotic drugs on human gut bacteria

(2018) Lisa Maier et al.   NATURE

Gut bacterial composition in a mouse model of Parkinson’s disease

(2018) P. Perez-Pardo et al.   Beneficial Microbes

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

(2018) Paula Perez-Pardo et al.   GUT

Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases

(2018) José E. Belizário et al.   MEDIATORS OF INFLAMMATION

Up-regulation of protective neuronal MicroRNAs by FTY720 and novel FTY720-derivatives

(2018) Javier Vargas-Medrano et al.   NEUROSCIENCE LETTERS

The Gut and Parkinson’s Disease: Hype or Hope?

(2018) Filip Scheperjans et al.   Journal of Parkinsons Disease

Could α-Synuclein Modulation of Insulin and Dopamine Identify a Novel Link Between Parkinson’s Disease and Diabetes as Well as Potential Therapies?

(2018) Guadalupe Vidal-Martinez et al.   Frontiers in Molecular Neuroscience

FTY720-derivatives do not induce FTY720-like lymphopenia

(2017) Ismael Segura-Ulate et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria

(2017) Jean Guy LeBlanc et al.   Microbial Cell Factories

Altered gut microbiome and metabolome in patients with multiple system atrophy

(2017) Ai Huey Tan et al.   MOVEMENT DISORDERS

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

(2017) Erin M. Hill-Burns et al.   MOVEMENT DISORDERS

The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy

(2017) Phillip A. Engen et al.   Journal of Parkinsons Disease

Connections between the human gut microbiome and gestational diabetes mellitus

(2017) Ya-Shu Kuang et al.   GigaScience

Dynamics of the human gut microbiome in inflammatory bowel disease

(2017) Jonas Halfvarson et al.   Nature Microbiology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice

(2016) Guadalupe Vidal-Martínez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models

(2016) Manru Ren et al.   NEUROCHEMICAL RESEARCH

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

(2016) Julius O. Enoru et al.   PLoS One

Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals

(2016) Kate L. Ormerod et al.   Microbiome

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates

(2015) Doris Vandeputte et al.   GUT

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

The gut microbiome, diet and links to cardiometabolic and chronic disorders

(2015) Judith Aron-Wisnewsky et al.   Nature Reviews Nephrology

Brain-gut-microbiota axis in Parkinson's disease

(2015) Agata Mulak   WORLD JOURNAL OF GASTROENTEROLOGY

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells

(2014) Javier Vargas-Medrano et al.   ACS Medicinal Chemistry Letters

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota

(2011) Matteo Serino et al.   GUT

Autonomic involvement in Parkinson's disease: Pathology, pathophysiology, clinical features and possible peripheral biomarkers

(2011) Maria G. Cersosimo et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies

(2010) S. S. C. Rao et al.   NEUROGASTROENTEROLOGY AND MOTILITY